Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D.

Pneumonia is a frequent-occurring event in children death. Vitamin D (VD) can alleviate inflammatory response and it might be a promising adjunct to antibiotics for the treatment of acute childhood pneumonia. This study intended to uncover the relevant mechanism of VD in pneumonia.

[The 161th lysine of C/EBPα in alveolar type II epithelial cells is modified by small ubiquitin-related modification].

Objective To clarify the interaction between CCAAT enhancer-binding protein α (C/EBPα) and small ubiquitin-related modification (SUMO) in human alveolar type II epithelial cells (AECII), and further identify its modification sites. Methods The expression of C/EBPα and SUMO1 in human AECII was detected by immunofluorescence double labeling. Co-IP was used to detect the interaction of C/EBPα and SUMO1 in AEC II.

[Dynamic expression and role of SUMO-modified C/EBPα in preterm rats with bronchopulmonary dysplasisa induced by hyperoxia exposure].

Objective: To study the expression of SUMO-modified CCAAT enhancer binding protein α (C/EBPα) in preterm rat model of bronchopulmonary dysplasisa (BPD) induced by hyperoxia exposure and its role.

Methods: Eighteen preterm rats were randomly divided into an air group and a hyperoxia group (n=9 each). The model of BPD was prepared in preterm rats exposed to hyperoxia.