Bifenthrin induces changes in clinical poisoning symptoms, oxidative stress, DNA damage, histological characteristics, and transcriptome in Chinese giant salamander (Andrias davidianus) larvae.

Bifenthrin (BF) is a broad-spectrum insecticide that has gained widespread use due to its high effectiveness. However, there is limited research on the potential toxic effects of bifenthrin pollution on amphibians. This study aimed to investigate the 50 % lethal concentration (LC) and safety concentration of Chinese giant salamanders (CGS) exposed to BF (at 0, 6.

Degradation of 2, 4-dichlorophenol by peroxymonosulfate catalyzed by ZnO/ZnMn O.

In this study, a highly efficient peroxymonosulfate (PMS) activator, ZnO/ZnMn O , was synthesized using a simple one-step hydrothermal method. The resulting bimetallic oxide catalyst demonstrated a homogenous and high-purity composition, showcasing synergistic catalytic activity in activating PMS for degrading 2, 4-dichlorophenol (2, 4-DCP) in aqueous solution. This catalytic performance surpassed that of individual ZnO, Mn O , and ZnMn O metal materials.

Evaluation of Chelator-to-Antibody Ratio on Development of Zr-iPET Tracer for Imaging of PD-L1 Expression on Tumor.

Zr-iPET has been widely used for preclinical and clinical immunotherapy studies to predict patient stratification or evaluate therapeutic efficacy. In this study, we prepared and evaluated Zr-DFO-anti-PD-L1-mAb tracers with varying chelator-to-antibody ratios (CARs), including Zr-DFO-anti-PD-L1-mAb_3X (), Zr-DFO-anti-PD-L1-mAb_10X (), and Zr-DFO-anti-PD-L1-mAb_20X (). The DFO-anti-PD-L1-mAb conjugates with varying CARs were prepared using a random conjugation method and then subjected to quality control.

Study on the catalytic degradation of Acid Orange 7 and the potential mechanism by ferrous-percarbonate.

Factors affecting the degradation of Acid Orange 7 (AO7) were evaluated and optimized when ferrous was used to catalyze percarbonate in the present study. The optimized conditions included the initial pH values ranging from 3 to 11 for AO7 solution, the initial level of AO7, sodium percarbonate (SPC), and Fe . Some ions and natural organic materials, which commonly exist in natural water, were also tested to evaluate their potential impacts on the degradation of AO7.

Comparison of BMIPP-SPECT/CT to FDG-PET/CT for Imaging Brown or Browning Fat in a Preclinical Model.

Obesity is a leading cause of preventable death and morbidity. To elucidate the mechanisms connecting metabolically active brown adipose tissue (BAT) and metabolic health may provide insights into methods of treatment for obesity-related conditions. F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is traditionally used to image human BAT activity.

Radiation Dose Due to Naturally Occurring Radionuclides in Soils from Varying Geological Environments.

Field radiation monitoring and radionuclide analysis of soils were performed at various geological areas in Taiwan. The field-observed dose rate was 0.031-0.

Evaluation of Injectable Chitosan-based Co-cross-linking Hydrogel for Local Delivery of Re-LIPO-DOX to Breast-tumor-bearing Mouse Model.

Background/aim: An injectable chitosan-based co-cross-linking thermosensitive hydrogel combining Re- and doxorubicin-encapsulated liposomes (C/GP/GE/Re-LIPO-DOX) was developed for the prevention of locoregional recurrence after mastectomy.

Materials And Methods: The hydrogel properties, in vitro drug release characteristics, and in vivo scintigraphy imaging attributes were investigated.

Results: The gelation time of the hydrogels can be controlled to be within 5 min.

Evaluation of 188Re-labeled PEGylated nanoliposome as a radionuclide therapeutic agent in an orthotopic glioma-bearing rat model.

Purpose: In this study, the (188)Re-labeled PEGylated nanoliposome ((188)Re-liposome) was prepared and evaluated as a therapeutic agent for glioma.

Materials And Methods: The reporter cell line, F98(luc) was prepared via Lentivector expression kit system and used to set up the orthotopic glioma-bearing rat model for non-invasive bioluminescent imaging. The maximum tolerated dose applicable in Fischer344 rats was explored via body weight monitoring of the rats after single intravenous injection of (188)Re-liposome with varying dosages before the treatment study.

⁹⁹mTc pyrene derivative complex causes double-strand breaks in dsDNA mainly through cluster-mediated indirect effect in aqueous solution.

Radiation therapy for cancer patients works by ionizing damage to nuclear DNA, primarily by creating double-strand breaks (DSB). A major shortcoming of traditional radiation therapy is the set of side effect associated with its long-range interaction with nearby tissues. Low-energy Auger electrons have the advantage of an extremely short effective range, minimizing damage to healthy tissue.

In vitro and in vivo evaluation of lactoferrin-conjugated liposomes as a novel carrier to improve the brain delivery.

In this study, lactoferrin-conjugated PEGylated liposomes (PL), a potential drug carrier for brain delivery, was loaded with radioisotope complex, 99mTc labeled N,N-bis(2-mercaptoethyl)-N',N'-diethylethylenediamine (99mTc-BMEDA) for in vitro and in vivo evaluations. The hydrophilicity of liposomes was enhanced by PEGylation which was not an ideal brain delivery system for crossing the blood brain barrier (BBB). With the modification of a brain-targeting ligand, lactoferrin (Lf), the PEGylated liposome (PL) might become a potential brain delivery vehicle.

Imaging, autoradiography, and biodistribution of (188)Re-labeled PEGylated nanoliposome in orthotopic glioma bearing rat model.

The (188)Re-labeled pegylated nanoliposome (abbreviated as (188)Re-Liposome) was prepared and evaluated for its potential as a theragnostic agent for glioma. (188)Re-BMEDA complex was loaded into the pegylated liposome core with pH 5.5 ammonium sulfate gradient to produce (188)Re-Liposome.

[Study on origin of meridians and collaterals through pain relieving effect of muscle regions].

Through analysis on sequencing of meridians and their muscle regions, their pertaining organs, run ning courses, linking and indications described in Zubi Shiyimai (Eleven Meridian of Foot and Hand), Yinyang Shiyimai (Eleven Meridian of Yinyang), Lingshu: Jingmai (Miraculous Pivot: Meridian) and Lingshu: Jinjing (Miraculous Pivot: Muscle Meridian), it is found that most of the indications of acupuncture in ancient time are symptoms of the muscle regions. 62.59% points of the national standard acupoints location close to tender points of the muscle regions, which indicates that the origin of early acupoints are tender points along the running courses of the muscle regions.

Development of a thermosensitive hydrogel system for local delivery of (188)Re colloid drugs.

A novel internal radiation therapy (IRT) mode intended for controlled local delivery of (188)Re-Tin colloid was developed by using chitosan-based thermosensitive hydrogel. Chitosan (C) and beta-glycerophosphate (beta-GP) were used to prepare the thermosensitive hydrogel (C/GP). The prepared C/GP hydrogel featured a rapid sol-gel transition within 5min after it was brought into an environment of 37 degrees C.