Publications by authors named "Fengyu Shi"

Acute pancreatitis (AP) is a highly fatal pancreatic inflammation. In recent years, synthetic nanoparticles have been extensively developed as drug carriers to address the challenges of systemic adverse reactions and lack of specificity in drug delivery. However, systemically administered nanoparticle therapy is rapidly cleared from circulation by the mononuclear phagocyte system (MPS), leading to suboptimal drug concentrations in inflamed tissues and suboptimal pharmacokinetics.

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  • Powdery mildew, caused by Blumeria graminis f. sp. tritici, is a highly destructive disease impacting wheat, particularly affecting common wheat, but durum wheat serves as a key resource for enhancement efforts.* -
  • The study identified a durum wheat variety (DR88) with strong resistance to powdery mildew, localizing the dominant resistance gene, PmDR88, to a specific region on chromosome arm 2AL and confirming its association with the Pm4 locus through extensive genotyping.* -
  • Despite PmDR88 sharing amino acid sequences with the Pm4d allele, it has distinct expression patterns; two complementary DNA markers were developed for efficient marker-assisted selection to integrate this
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Background: Acute pancreatitis (AP) is a prevalent and serious condition within the digestive system, with approximately 20 % to 30 % of cases advancing to severe acute pancreatitis (SAP). During the initial phases of SAP, macrophages are activated in response to the substantial amounts of acinar cell contents and damage-associated molecular patterns (DAMPs) resulting from acinar cell destruction. Subsequently, activated macrophages release a significant array of pro-inflammatory factors that exacerbate the progression of SAP.

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Stem nematode (Ditylenchus destructor Thorne) is considered one of the most economically devastating species affecting sweet potato production. Biocontrol offers a sustainable strategy for nematode control. This study conducted a pot experiment to evaluate the biocontrol efficacy of Paecilomyces lilacinus CS-Z and Bacillus pumilus Y-26 against the stem nematode, as well as to examine their influence on the bacterial communities in the sweet potato rhizosphere.

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  • Acute pancreatitis (AP) is a serious stomach disease that often sends people to the hospital, and scientists want to find better treatments for it.
  • Researchers studied a protein called PFKFB3 in mice to see how it affects severe cases of AP known as severe alcoholic pancreatitis (SAP).
  • They discovered that PFKFB3 makes SAP worse by messing with calcium levels inside certain cells, and they think it could be a good target for new medicines to make the disease less severe.
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Acute pancreatitis (AP) is a non-infectious pancreatic enzyme-induced disorder, a life-threatening inflammatory condition that can cause multi-organ dysfunction, characterized by high morbidity and mortality. Several therapies have been employed to target this disorder; however, few happen to be effectively employable even in the early phase. PFKFB3(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3) is a critical regulator of glycolysis and is upregulated under inflammatory, mitogenic, and hypoxia conditions.

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Due to the rising concentration of atmospheric CO, climate change is predicted to intensify episodes of drought. However, our understanding of how combined environmental conditions, such as elevated CO and drought together, will influence crop-insect interactions is limited. In the present study, the direct effects of combined elevated CO and drought stress on wheat () nutritional quality and insect resistance, and the indirect effects on the grain aphid () performance were investigated.

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Nanopesticides with controlled release can achieve more effective utilization of pesticides. Here, to enhance the adsorption of pesticides onto the target organisms, the formulation of pesticides with temperature-responsive release was proposed by combing graphene oxide (GO) and existing pyrethroid pesticides (cyhalothrin, bifenthrin and fenpropathrin). Pesticides were loaded onto GO nanosheets as a carrier a simple physisorption process, and the GO-pesticide nanocomposites exhibited temperature-responsive release and excellent storage stability, which are of vital importance to the practical application.

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Background: Atractylodes chinensis (DC.) Koidz is a well-known medicinal plant containing the major bioactive compound, atractylodin, a sesquiterpenoid. High-performance liquid chromatography (HPLC) analysis demonstrated that atractylodin was most abundant in 3-year old A.

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  • Powdery mildew and leaf rust are common diseases affecting wheat globally, and using resistant wheat cultivars is the best way to control these issues economically and environmentally.
  • In a study of 2,978 wheat accessions, 22.1% showed high resistance to powdery mildew and some accessions were also resistant to leaf rust, with 17 accessions resistant to both diseases.
  • Genetic testing revealed specific resistance genes in many accessions, identifying a total of 10 genes associated with leaf rust and 7 with powdery mildew, while also suggesting the presence of unknown resistance genes not previously characterized.
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Plants are routinely subjected simultaneously to different abiotic and biotic stresses, such as heat, drought, and insect infestation. Plant-insect interactions in such complex stress situations are poorly understood. We evaluated the performance of the grain aphid (Sitobion avenae) in wheat (Triticum aestivum L.

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Objective: The aim of this study was to investigate endophytic bacterial diversity of wild soybean varieties with different resistance to soybean cyst nematode(Heterodera glycines) , for deciphering the interactions of soybean cyst nematode with endophytic bacteria.

Methods: After screening wild soybean varieties against race 3 of H. glycines, we investigated endophytic bacterial diversity in root tissues of wild soybean varieties with different resistance to H.

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  • The soybean cyst nematode (SCN) significantly reduces soybean yield and quality globally, and natural biological control through bacterial communities may help manage SCN populations.
  • In a study, soil samples were analyzed from fields with varying durations of soybean monoculture (2 to 41 years) to assess SCN densities and the associated bacterial communities using Biolog and PCR-DGGE techniques.
  • Results indicated that SCN densities rose during the first 5 years of monoculture but declined sharply thereafter, with specific bacterial groups like Streptomyces and Rhizobium identified, suggesting that longer monoculture alters the bacterial community structure associated with SCN cysts.
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Objective: To understand the bacterial diversity isolated from the cysts of Heterodera glycines in the soybean field in Heilongjiang Province.

Methods: Bacteria were isolated from cysts on nutrient agar plates using dilution plate method and further identified by phylogenetic analysis based on 16S rDNA gene sequences.

Results: Totally 90 bacteria strains with different colony morphology were selected on nutrient agar plate and their phylogenetic features were analyzed based on the partial 16S rDNA sequences.

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