Publications by authors named "Fengyu Chi"
Human enteroviruses (EVs) represent a global public health concern due to their association with a range of serious pediatric illnesses. Despite the high morbidity and mortality exerted by EVs, no broad-spectrum antivirals are currently available. Herein, we presented evidence that doxycycline can inhibit in vitro replication of various neurotropic EVs, including enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and coxsackievirus (CV)-A6, in a dose-dependent manner.
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- SARS-CoV-2, the virus responsible for COVID-19, produces accessory proteins that affect the immune response, but their roles and how they trigger immune reactions in humans and mice are not fully understood.
- The study used various methods to detect specific antibodies against these accessory proteins in the blood of COVID-19 patients, finding that antibodies for proteins 3a and 7b were particularly linked to severe cases.
- Although some proteins triggered antibody production in mice, these antibodies were not effective in neutralizing the virus, indicating that while accessory proteins are expressed, they might not provide protective immunity.