Publications by authors named "Fengyong Guo"

Rationale: Slipped capital femoral epiphysis (SCFE) is a common adolescent hip disorder, but its association with hypothyroidism remains rare and poorly understood. This case highlights the importance of considering endocrine disorders, such as hypothyroidism, as potential risk factors in atypical SCFE presentations, particularly when trauma or other common etiologies are absent.

Patient Concerns: A 14-year-old boy presented with progressive, nontraumatic left hip pain that worsened over 6 weeks, eventually leading to complete immobility.

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Article Synopsis
  • Staphylococcus aureus protein A (SPA) disrupts bone formation by inducing apoptosis in osteoblasts and affects the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs).
  • Researchers identified 321 differentially expressed genes (DEGs) from SPA-interfered BMSCs and established a protein-protein interaction (PPI) network, identifying 6 potential biomarkers (Cenpf, Kntc1, Nek2, Asf1b, Troap, Kif14) that differentiate between normal and SPA-interfered BMSCs.
  • The study revealed that the identified biomarkers are primarily involved in pyrimidine metabolism and showed significantly lower expression levels in the SPA-interfered group,
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