Mutation spectrum and genotype-phenotype correlation of pediatric patients with methylmalonic acidemia.

Background: MMA incidence is significantly greater in China than in the rest of the world, but the mutation spectrum of MMA in China has not yet been mapped.

Methods: We summarized published MMA-related articles and conducted a systematic meta-analysis of the literature.

Results: We analyzed the gene variants information of 926 pediatric MMA patients in China; 517 were children with combined MMA, and 409 were children with isolated MMA.

Erratum: Thioredoxin 1 supports colorectal cancer cell survival and promotes migration and invasion under glucose deprivation through interaction with G6PD: Erratum.

[This corrects the article DOI: 10.7150/ijbs.71809.

Matching degree of embodied carbon trade and value-added trade among Chinese provinces (regions).

This paper constructs a matching index model to research the matching degree of embodied carbon trade and value-added trade among eight regions and 31 provinces in China in 2012 and 2015. The study finds that (1) At the regional level, a mismatch is shown between embodied carbon trade and value-added trade among regions, for example, in 2015, the northwest region has output embodied carbon to the north coast, while input the value-added trades from the north coast. (2) At the provincial level, a mismatch is displayed between embodied carbon transaction and value-added trade, for example, Beijing had a net shift of embodied carbon from Xinjiang in 2015, but Xinjiang had a net transfer of added value from Beijing.

The Chemical Signatures of Water Extract of Rosc.

Background: Ginger (Z. officinale Rosc.) is a common herb and is widely used as a diet-based or home therapy in traditional medicine worldwide.

Neural bases of motivated forgetting of autobiographical memories.

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear.

Thioredoxin 1 supports colorectal cancer cell survival and promotes migration and invasion under glucose deprivation through interaction with G6PD.

Overcoming energy stress is a critical step for cells in solid tumors. Under this stress microenvironment, cancer cells significantly alter their energy metabolism to maintain cell survival and even metastasis. Our previous studies have shown that thioredoxin-1 (Trx-1) expression is increased in colorectal cancer (CRC) and promotes cell proliferation.

Reduced cell invasion may be a characteristic of placental defects in pregnant women of advanced maternal age at single-cell level.

The mechanisms underlying pregnancy complications caused by advanced maternal age (AMA) remain unclear. We analyzed the cellular signature and transcriptomes of human placentas in AMA women to elucidate these mechanisms. Placental tissues from two AMA women and two controls were used for single-cell RNA-sequencing (scRNA-seq).

Clinical evaluation of non-invasive prenatal screening for the detection of fetal genome-wide copy number variants.

Objective: This study explores and discusses the possible factors affecting the positive predictive value (PPV) of non-invasive prenatal screening (NIPS) for the detection of fetal copy number variants (CNVs) in pregnant women.

Methods: NIPS was performed for 50,972 pregnant women and 212 cases were suspected as fetal CNVs. Post additional genetic counseling for these women, 96 underwent invasive prenatal diagnosis (amniocentesis), following which they received chromosomal microarray analysis (CMA).

Superior frontal gyrus and middle temporal gyrus connectivity mediates the relationship between neuroticism and thought suppression.

Thought suppression, which is defined as an effort "not to think about" a particular thought, is essential to maintain good mental health. Despite previous functional imaging studies on thought suppression and related functional activity, the neural basis of thought suppression in individual difference is still unclear. Many studies have focused on the relationship between neuroticism and thought suppression; however, the neural basis of this relationship is not well known.

Estimating the frequency of causal genetic variants in foetuses with congenital heart defects: a Chinese cohort study.

Background: The belief that genetics plays a major role in the pathogenesis of congenital heart defects (CHD) has grown popular among clinicians. Although some studies have focused on the genetic testing of foetuses with CHD in China, the genotype-phenotype relationship has not yet been fully established, and hotspot copy number variations (CNVs) related to CHD in the Chinese population are still unclear. This cohort study aimed to assess the prevalence of chromosomal abnormalities in Chinese foetuses with different types of CHD.

Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy.

Two dimensional black phosphorus nanosheets (BP NSs) have attracted plenty of attention in the research field of cancer photonic therapy. However, the poor stability and relatively low efficiency of reactive oxygen species (ROS) generation of BP NSs limit their practical application. To address these drawbacks, herein we report a red/black phosphorus (RP/BP) composite nanosheet, M-RP/BP@ZnFeO, which was synthesized by (1) partially converting red phosphorus (RP) to black phosphorus (BP) followed by liquid-phase ultrasonic exfoliation to form RP/BP NSs, (2) synthesis of ZnFeO nanoparticles on the surface of RP/BP NSs, (3) and wrapping with the MCF-7 cell membrane.

Research on China's embodied carbon import and export trade from the perspective of value-added trade.

The development of globalization has separated the production and consumption of products spatially, and the international trade of products has become a carrier of embodied carbon trade. This paper adopted the perspective of value-added trade to calculate the amount of embodied carbon trade of China from 2006 to 2015 and perform a structural decomposition analysis of the changes in China's embodied carbon trade. This study found that: (1) China's embodied carbon exports are much larger than its embodied carbon imports, and there are differences between countries.

Mycoplasma synoviae induces serum amyloid A upregulation and promotes chicken synovial fibroblast cell proliferation.

Mycoplasma synoviae (MS) infection causes infectious synovitis and arthritis with hyperplasia of synovial cells in the chicken joint. However, its mechanism is unknown. We used primary chicken synovial fibroblast (CSF) as the research object to study the role of MS in the proliferation of MS-infected CSF and determine the mechanisms involved.

Comparative Genomics of and New Targets for Molecular Diagnostics.

is an important pathogen of poultry, causing significant economic losses in this industry. Analysis of the unique genes and shared genes among different strains and among related species is helpful for studying the molecular pathogenesis of and provides valuable molecular diagnostic targets to facilitate the identification of species. We selected a total of 46 strains, including six strains, from 25 major animal (including avian) species/subspecies that had complete genome sequences and annotation information published in GenBank, and used them for comparative genomic analysis.

Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy.

Black phosphorus quantum dots (BPQDs) with excellent biocompatibility, outstanding photothermal and photodynamic efficacies have attracted significant attention in cancer therapy. However, the low environmental stability and poor dispersity of BPQDs limit their practical applications. In the present work, biocompatible anionic waterborne polyurethane (WPU) nanoparticles were synthesized from castor oil to encapsulate the BPQDs.

Interaction of Mycoplasma synoviae with chicken synovial sheath cells contributes to macrophage recruitment and inflammation.

Mycoplasma synoviae (MS) is an important avian pathogen causing considerable economic hardship in the poultry industry. A major inflammation caused by MS is synovitis that occurs in the synovial tendon sheath and joint synovium. However, the overall appearance of pathological changes in the tendon sheath and surrounding tissues caused by MS infection at the level of pathological tissue sections was poor.

Social network analysis of virtual water trade among major countries in the world.

This study utilizes multi-region input-output model to calculate the virtual water trade among 19 major countries (the Group 20 countries, except the EU) from 2006 to 2015. Moreover, this paper uses network analysis method to study the characteristics of virtual water trade networks. Results show that: (1) the import and export of the virtual water trade among 19 major countries in 2015 increased in varying degrees.

Identification of key sectors of water resource utilization in China from the perspective of water footprint.

We identified the key sectors of water resource use in China from the perspective of the water footprint to improve the use of water resources. The empirical results showed that there were six key sectors (including Crop Cultivation; Forestry; Livestock and Livestock Products; Fishery, Technical Services for Agriculture, Forestry, Livestock and Fishing; Other Food Products, and Scrap and Waste) for water consumption in China in 2015.We analyzed the use of green water, blue water, and grey water.

Development of a live attenuated duck hepatitis A virus type 3 vaccine (strain SD70).

Duck hepatitis A virus type 3 (DHAV-3) is an important pathogen that causes substantial losses in the Chinese duck industry. DHAV-3 is highly fatal to ducklings and there is no licensed vaccine in China available to reduce DHAV-3 infection. Our goal was to develop a live attenuated vaccine candidate against DHAV-3.

Integrated Transcriptomic and Proteomic Analyses of the Interaction Between Chicken Synovial Fibroblasts and .

(MS), which causes respiratory disease, eggshell apex abnormalities, infectious synovitis, and arthritis in avian species, has become an economically detrimental poultry pathogen in recent years. In China, the disease is characterized by infectious synovitis and arthritis. However, the mechanism by which MS causes infectious synovitis and arthritis remains unknown.

Complete Genome Sequencing of Mycoplasma synoviae Strain HN01, Isolated from Chicken in Henan Province, China.

Here, we report the complete genome sequence of HN01, a virulent epidemic strain isolated from a sick chicken with synovitis in Henan Province, China. HN01 is the Asian source of an strain that is completely sequenced, genome annotated, and published with relevant data.

Immune-related miRNA-mRNA regulation network in the livers of DHAV-3-infected ducklings.

Background: Duck hepatitis A virus type 3 (DHAV-3) is one of the most harmful pathogens in the duck industry. However, the molecular mechanism underlying DHAV-3 infection in ducklings remains poorly understood. To study the genetic regulatory network for miRNA-mRNA and the signaling pathways involved in DHAV-3 infection in ducklings, we conducted global miRNA and mRNA expression profiling of duckling liver tissues infected with lethal DHAV-3 by high-throughput sequencing.

Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer.

Background: Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC.

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation.

Background: Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated.

Methods: We generated lentiviral constructs to overexpress and silence HOXB8 in CRC cell lines, and examined their biological functions through MTT, wound healing, colony and transwell, expression of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) related factors through western-blot.

Results: HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo.