CagA-positive may promote and aggravate scrub typhus.

() infection may alter the host's resistance to disease pathogens through the Th1 immune response, leading to potential synergistic pathogenic effects. A total of 117 scrub typhus cases at Beihai People's Hospital and affiliated hospitals of Youjiang University for Nationalities and Medical Sciences were studied from January to December 2022, alongside 130 healthy individuals forming the control group. All participants underwent serum antibody testing.

[Response of Cadmium in Soil-rice to Different Conditioners Based on Field Trials].

A plot experiment was carried out to assess the applicability of soil conditioners on Cd-polluted acidic paddy fields. The effects of five soil conditioners[Tianxiang 1 Hao (TX1), limestone (Li), silicon fertilizer, Nuodikang (NDK), and calcium magnesium phosphate fertilizer (CaMg-P)] on Cd accumulation and transport between contaminated soil and rice plants and rice yield on the land were analyzed. The results showed that compared with that under the control, other tested methods increased soil pH by 0.

Comparing the efficacy of thyroglobulin and thyroglobulin/ thyroid-stimulating hormone ratio models in predicting a successful response to radioactive iodine therapy.

Background: The thyroglobulin (Tg)/ thyroid-stimulating hormone (TSH) ratio has manifested to be a reliable marker for predicting prognosis in patients with differentiated thyroid carcinoma (DTC). The objective of this study was to compare the efficacy of Tg and Tg/TSH ratio models in predicting a successful response to radioactive iodine therapy.

Methods: One thousand six hundred forty-two DTC patients receiving I radiotherapy were finally enrolled in this retrospective study.

[Characteristics and Planting Safety Assessment of As Content in Dryland Soil and Maize in Guizhou Province].

In order to understand the distribution characteristics of As content in dryland soils and maize seeds in Guizhou province and to evaluate the safety of maize cultivation, 468 natural soil samples, 1260 dryland surface soil samples, and 980 corresponding maize seed samples were systematically collected to determine their As content and basic physicochemical properties. The degree of contamination of the samples was evaluated by using the single-factor contamination index method. The results showed that: ① the range of (As) in dryland soil was 0.

Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index.

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease worldwide. Up to 70%-80% of patients with NAFLD were obese, especially abdominal obesity. Many indicators of abdominal obesity have been reported, including waist circumference (WC), visceral obesity index (VAI), lipid accumulation (LAP), and Chinese VAI (CVAI).

[Characteristics of Antimony Migration and Transformation and Pollution Evaluation in a Soil-Crop System Around a Tin Mine in Hunan Province].

This study used 193 sets of farmland soil and agricultural product samples collected from around a tin mine in Hunan Province, China, to explore the antimony (Sb) content characteristics and pollution status of soil and agricultural products and to provide a scientific basis for the prevention and control of soil antimony pollution in antimony mining areas and the safe use of farmland. We analyzed the amount of antimony in the soil, basic physical and chemical properties, and antimony content in agricultural products; studied the characteristics of antimony migration and transformation in the soil-agricultural product system; and conducted safety assessments on soil and agricultural products. The results showed that the soil (Sb) in the central area of the mine, the southern area of the mine, the central township area, the urban-rural transfer area, and the northern area of the mine reached (2348±2165), (1298±884.

Delay of initial radioactive iodine therapy beyond 3 months has no effect on clinical responses and overall survival in patients with thyroid carcinoma: A cohort study and a meta-analysis.

Background: More than a third of thyroid carcinoma (TC) patients require treatment with radioactive iodine (RAI), but the timing of initial RAI therapy after thyroidectomy remains controversial.

Methods: We included 1224 differentiated thyroid carcinoma (DTC) patients during 2015-2019, divided them into the early (≤3 months) and the delayed (>3 months) groups based on the interval between surgery and the initial RAI. Clinical outcomes were assessed within 6-8 months of treatment with RAI, including excellent response (ER), indeterminate response (IDR), biochemical incomplete (BIR) and structural incomplete response (SIR).

Burden of Thyroid Cancer From 1990 to 2019 and Projections of Incidence and Mortality Until 2039 in China: Findings From Global Burden of Disease Study.

Projecting the burden of thyroid cancer (TC) over time provides essential information to effectively plan measures for its management and prevention. This research obtained data from the Global Burden of Disease (GBD) Study from between 1990 and 2019 to model how TC will affect China until 2039 by conducting the Bayesian age-period-cohort analysis. The number of new TC cases in China was 10,030 in 1990, 39,080 in 2019, and is projected to be 47,820 in 2039.

SLC34A2 Up-regulation And SLC4A4 Down-regulation Correlates With Invasion, Metastasis, And The MAPK Signaling Pathway In Papillary Thyroid Carcinomas.

Papillary thyroid carcinoma (PTC) is one of the fastest growing endocrine system malignant carcinomas detected over the past decade. Unfortunately, more than 25% of PTC patients are characterized by their aggressiveness and subsequent metastasis; these characteristics usually indicate poor prognosis. Recently, increasing evidence has suggested that solute carrier (SLC) transporters may play a pivotal role in the initiation, invasion and metastasis of human carcinoma.

Preablative Stimulated Thyroglobulin and Thyroglobulin Reduction Index as Decision-Making Markers for Second Radioactive Iodine Therapy in Patients with Structural Incomplete Response.

Purpose: The aim of this study was to evaluate the value of preablative stimulated thyroglobulin (presTg) and thyroglobulin reduction index (TRI) to predict the different responses to second radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with structural incomplete response (SIR).

Patients And Methods: A single-center retrospective study analyzed the different clinical outcomes after second RAI therapy in 206 patients with SIR. PresTg1 and presTg2 were measured before first and second RAI management and TRI was the reduction index of presTg1 and presTg2.

Research trends for papillary thyroid carcinoma from 2010 to 2019: A systematic review and bibliometrics analysis.

Background: Thyroid carcinoma comprises the fastest rising incidence of carcinomas over the past decade. Papillary thyroid carcinoma (PTC) is the most predominant type of thyroid carcinoma. This study aimed to assess the research trends in the field of PTC.

A pre-ablative thyroid-stimulating hormone with 30-70 mIU/L achieves better response to initial radioiodine remnant ablation in differentiated thyroid carcinoma patients.

Our aim was to clarify the optimum pre-ablative thyroid-stimulating hormone (TSH) level for initial radioiodine remnant ablation (RRA) in patients with differentiated thyroid carcinoma (DTC). From December 2015 to May 2019, 689 patients undergone RRA at Nuclear Medicine Department, Second Hospital of Shandong University were included in the study. Patients were categorized by their pre-ablative TSH level grouping of < 30, 30-70 and ≥ 70 mIU/L.

Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma.

The aim of the present study was to elucidate the association between excessive chronic iodine exposure and the risk of developing papillary thyroid carcinoma (PTC). The demographic information and pathological characteristics of patients with thyroid nodules were retrieved from medical records at The Second Hospital of Shandong University. A fasting urine specimen was collected, and creatinine and urinary iodine concentration (UIC) were determined.

Breakthrough of ZrO nanoparticles into fetal brains depends on developmental stage of maternal placental barrier and fetal blood-brain-barrier.

Ingestion of nanoparticles may cause various damages to human body. However, how such ingestion by pregnant mother influences fetal development is not known because, presumably, ingested nanoparticles have to cross multiple biological barriers (such as intestinal and placental) to reach fetus. To answer this crucial question, here we investigated how a relatively biocompatible zirconia nanoparticles (ZrO NPs, 16 nm) were translocated to fetal brains in three exposure models of pregnant mice: Model 1, oral exposure of nanoparticles before maternal blood-placental barrier (BPB) was fully developed; Model 2, exposures after BPB was developed, but before fetal blood-brain-barrier (BBB) was fully developed; Model 3, exposures after both maternal BPB and fetal BBB were fully developed.

Oral intake of ZrO nanoparticles by pregnant mice results in nanoparticles' deposition in fetal brains.

Nanotoxicity to fetal brains after maternal oral exposures during pregnancy is often in question because nanoparticles have to cross multiple biological barriers such as intestinal barrier, maternal blood placental barrier (BPB) and fetal blood brain barrier (BBB). Here, we investigated this seemingly impossible passage for ZrO nanoparticles (ZrO NPs) from maternal body to fetal brains using a pregnant mouse model. After three oral exposures to pregnant mice at late pregnancy (GD16, 17, 18), ZrO NPs were able to accumulate in fetal brains at GD19 via crossing the well-developed maternal BPB and fetal BBB.

Carbon disulfide induced decidualization disorder in the mice uterus at the window of implantation.

Carbon disulfide (CS) is regarded as a common occupational poison that is widely used in the textile industry in China. Our previous research suggests that CS can induce significant implantation disorders in pregnant mice; however, the specific mechanism remains unclear. Uterine conception in mice must undergo decidualization, which is the prerequisite for propitious blastocyst implantation into the endometrium.

Carbon Disulfide Induces Embryo Implantation Disorder by Disturbing the Polarization of Macrophages in Mice Uteri.

Carbon disulfide (CS) induces embryo implantation disorders. Macrophages participate in the process of pregnancy. Therefore, we want to explore the effects of CS exposure on polarization and immune function of macrophages in pregnant mice uteri.

Research Trends of Macrophage Polarization: A Bibliometric Analysis.

Background: Macrophage polarization is involved in the development of many diseases such as obesity, diabetes, and cancer. This study aimed to understand the trends and hotspots of macrophage polarization research.

Methods: We searched through the Web of Science Core Collection database to obtain original articles in this research domain.

Carbon disulfide induces embryo loss by perturbing the expression of the mTOR signalling pathway in uterine tissue in mice.

Understanding of the mechanism of embryo loss is critical for successful pregnancy considering an increase in the incidence of infertility. In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS). CS is a material used in certain production processes, and women are sometimes exposed to it in occupational settings.

The reproductive and developmental toxicity of nanoparticles: A bibliometric analysis.

Because of the advantages of nanoparticles (NPs) in a variety of industrial, biomedical, and consumer applications, they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human body. However, to date, the detrimental effects of NPs are still unclear, especially in reproductive and developmental toxicity. In this study, we researched 266 articles related to the reproductive and developmental toxicity of NPs from 2006 to December 2016 based on the database of the Web of Science.