Publications by authors named "Fengxue Qin"
Article Synopsis
- A series of new hybrid compounds were created by combining capsaicin and tacrine to target Alzheimer’s disease, showing strong inhibition of key enzymes involved in the condition.
- Most compounds exhibited good blood-brain barrier permeability, with compound 5s standing out due to its balanced and effective inhibitory effects on essential enzymes related to AD and its low toxicity in various cell assays.
- Compound 5s also demonstrated safety in animal tests and showed potential to improve memory in mice, indicating it could be a promising treatment option for Alzheimer’s disease.
Hepatocellular carcinoma (HCC) belongs to the most frequent cancer with a high death rate worldwide. Thousands of long non-coding RNAs (lncRNAs) have been confirmed to influence the development of human cancers, including HCC. Nevertheless, the biological role of PRR34 antisense RNA 1 (PRR34-AS1) in HCC remains obscure.
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- Long non-coding RNAs (lncRNAs) have a significant role in the development of hepatocellular carcinoma (HCC), with the study focusing on the lncRNA LL22NC03-N14H11.1 and its effects on mitochondrial fission and HCC progression.
- The research utilized various bioinformatics tools and assays to identify dysregulated lncRNAs and examine the biological functions of LL22NC03-N14H11.1, finding it upregulated in HCC tissues and linked to increased cell proliferation and invasion.
- Mechanistically, LL22NC03-N14H11.1 interacts with c-Myb to inhibit LZTR1, affecting H-RAS signaling pathways, which ultimately promotes mitochondrial fission