Extraction and characterization of anti-virus anthraquinones from Nicotiana tabacum-derived Aspergillus oryzae YNCA1220.

In this study, seven novel anthraquinones (1-7) and four described anthraquinones (8-11) were purified from Nicotiana tabacum-derived Aspergillus oryzae YNCA1220. It is worth noting that only analogs of 4 and 5 have been reported as natural products to date, while the nuclei of compounds 1-3, 6 and 7 were isolated for the first time in nature. Among them, compounds 1-3 bear an unusual anthra[2,3-b]furan-9,10-dione nucleus, 4 and 5 possess a rare 3-methyl-1H-pyrrol-2-yl substituent, and 6 and 7 are new framework anthraquinones bearing a 6-methyl-1,7-dihydro-2H-azepin-2-one ring.

Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Methanolic Extracts, Fractions, and Isolated Compounds.

is a traditional Dai medicine plant belonging to the Lamiaceae family, which can be used to treat malaria, inflammation, diabetes, liver disease, bronchitis, tumors, cholelithiasis, jaundice, skin disease and as an anti-helminthic. To find more novel therapeutic agents contained in this medicinal plant, the antioxidant, anti-inflammatory and anti-diabetic activities of methanolic extract, fractions and compounds were evaluated. In this study, 26 compounds were isolated from the leaves and branches of .

Three new chromones from the whole plants of and their anti-rotavirus activities.

() is a perennial herb of leguminosae, which increasingly being grown as a forage in China. In our search for original bioactive metabolites from plants, the phytochemical reinvestigation of the was carried out, which led to the isolation of three new (-) and six known (-) chromones. Their structures were confirmed by spectroscopic methods, including extensive 1D and 2D NMR techniques.

Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities.

In previous studies, several isoindolin-1-one analogs that exhibited significant anti-tobacco mosaic virus (anti-TMV) activities were isolated from Nicotiana tabacum. Since gene-editing mutants provide a new sample for the discovery of active metabolites, we focused on the stems of YN-18-23 (a mutant N. tabacum for gene editing with the alkaloid metabolic pathway cultivated by Yunnan Tobacco Company), which led to the isolation of four new (1-4) and four known (5-8) isoindolin-1-ones.

Isochromenes from the -derived endophytic fungus and their anti-tobacco mosaic virus activities.

Three new isochromenes, (5-methoxy-7-prenyl-1-isochromen-3-yl)methanol (), 3-(3-(hydroxymethyl)-5-methoxy-1-isochromen-7-yl)propan-1-ol (), and (5-methoxy-7-methyl-1-isochromen-3-yl)methanol (), along with three known analogues (-) were isolated from the fermentation products of a -derived endophytic fungus . Their structures were elucidated by spectroscopic methods, including extensive 1 D and 2 D NMR techniques. Compounds - and were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities.

Indole Alkaloids and Chromones from the Stem Bark of and Their Antiviral Activities.

The (Leguminosae) genus has attracted a lot of attention as a prolific source of alkaloids and chromones with diverse structures and biological properties. The aim of this study is to screen the antiviral compounds from . The extract of the stem bark of this plant was separated using silica gel, MCI, ODS C18, and Sephadex LH-20 column chromatography, as well as semi-preparative HPLC.

Corrigendum: Dimeric Pimprinine Alkaloids From Soil-Derived sp. NEAU-C99.

[This corrects the article DOI: 10.3389/fchem.2020.

Dimeric Pimprinine Alkaloids From Soil-Derived sp. NEAU-C99.

Six new pimprinine alkaloids (-), including four dimers, dipimprinines A-D (-), and two monomers, (±)-Pimprinol D (), and pimprinone A (), along with six known congeners (-), were isolated from a soil-derived actinomycete sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations.

Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived .

Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (-), together with three known congeners, -, were isolated from culture broth of the soil-derived sp. KIB-H1471. Their structures were elucidated by using 1D and 2D NMR analyses in combination with HRESIMS data.

New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318.

Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis.

Study on the interaction between salvianic acid A sodium and bovine serum albumin by spectroscopic methods.

The interaction between salvianic acid A sodium (SAS) and bovine serum albumin (BSA) was investigated using fluorescence and ultraviolet spectroscopy at different temperatures under imitated physiological conditions. The experimental results showed that the fluorescence of BSA was quenched by SAS through a static quenching procedure. The binding constants of SAS with BSA were 2.

Study of the interaction between N-confused porphyrin and bovine serum albumin by fluorescence spectroscopy.

The fluorescence and ultraviolet spectroscopy were explored to study the interaction between N-confused porphyrins (NCP) and bovine serum albumin (BSA) under imitated physiological condition. The experimental results indicated that the fluorescence quenching mechanism between BSA and NCP was static quenching procedure at low NCP concentration at 293 and 305 K or a combined quenching (static and dynamic) procedure at higher NCP concentration at 305 K. The binding constants, binding sites and the corresponding thermodynamic parameters ΔH, ΔS, and ΔG were calculated at different temperatures.

Spectroscopic investigation of the interaction between diperoxovanadate complexes and benzimidazole-like ligands.

To understand the effects of benzimidazole substitution on reaction equilibrium, the interactions between a series of benzimidazole-like ligands and [OV(O₂)₂(D₂O)]⁻/[OV(O₂)₂(HOD)]⁻ in solution were explored by a combination of multinuclear ((1)H, (13)C, and (51)V) magnetic resonance and variable temperature NMR in 0.15 mol/L NaCl ionic medium for mimicking the physiological condition. Some direct NMR data are reported for the first time.

Spectroscopic studies on the interactions between 3,4-dihydropyrimidin-2(1H)-ones and bovine serum albumin.

The interactions between 3,4-dihydropyrimidin-2(1H)-ones (DHPM) and bovine serum albumin (BSA) were investigated by fluorescence and ultraviolet spectroscopy under imitated physiological conditions. The experimental results showed that all DHPM could form complexes with BSA. Static quenching and non-radiation energy transfer are the main reasons leading to the fluorescence quenching.