Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways.

Scopoletin (SC) is one of the important phenolic coumarin constituents derived from many edible plants and fruits, and exerts a wide range of biological activities. In the present study, we investigated the effects of SC on tyloxapol (TY)-induced hyperlipidemia and hepatic steatosis in C57BL/6j mice and free fatty acid (FFA) 0.5 mM-stimulated lipid accumulation in human L02 cells.