Rota-Tripsy or step-up-approach rotational atherectomy for severe coronary artery calcification treatment: a comparative effectiveness study.

Step-up-approach rotational atherectomy has been widely recognized in the treatment of severe calcified plaques. As an alternative, the rota-tripsy procedure is a novel strategy for the modification of calcification lesions. This study aimed to evaluate and compare the efficacy and safety of rota-tripsy and step-up-approach rotational atherectomy, given the limited clinical data available.

Gold metallene-based ECL biosensor to detect miRNA-126 for coronary artery calcification diagnosis.

Coronary artery calcification (CAC) is a pathological change and independent risk factor in cardiovascular diseases. In this work, a gold-based metallene structure was prepared as sensing interface based on mPEG-SH modified Au nanoparticles for the CAC detection. Firstly, a novel nanovesicle was self-assembled with excellent conductivity.

Intracoronary imaging-guided rotational atherectomy combined with intravascular lithotripsy in the treatment of severe coronary artery calcification-A case report.

Background: Severe coronary artery calcification increases the difficulty of percutaneous coronary intervention procedures and impairs stent expansion. Herein, we report a case of a patient who was successfully treated with rotational atherectomy using a stepped burr strategy combined with intravascular lithotripsy for plaque modification under intracoronary imaging.

Case Summary: A 65 year-old woman presented to our hospital with recurrent chest pain evolving for 1 year.

Differential microRNA Expression and Regulation in the Rat Model of Post-Infarction Heart Failure.

Background: Heart failure is a complex end stage of various cardiovascular diseases with a poor prognosis, and the mechanisms for development and progression of heart failure have always been a hot point. However, the molecular mechanisms underlying the post transcriptional regulation of heart failure have not been fully elucidated. Current data suggest that microRNAs (miRNAs) are involved in the pathogenesis of heart failure and could serve as a new biomarker, but the precise regulatory mechanisms are still unclear.