Facilely synthesized pH-responsive fluorescent polymer dots entrapping doped and coupled doxorubicin for nucleus-targeted chemotherapy.

Doxorubicin (Dox) functionalization methods can affect the Dox loading efficiency and release capability in nanosized drug delivery systems. Herein, different Dox-functionalized (doping, coupling, and doping and coupling) fluorescent poly(9,9-dioctylfluorene-alt-benzothiadiazole) (PFBT) polymer dots were designed and their application performance was evaluated. Polyethylene glycol-modified doxorubicin (PEG-Dox) was synthesized using a responsive hydrazone linker.

A transferrin-target magnetic/fluorescent dual-mode probe significantly enhances the diagnosis of non-small cell lung cancer.

To enhance the diagnosis of non-small cell lung cancer (NSCLC), we prepared a dual-modal probe Cy5.5-Tf-Gd-DTPA. Gd-DTPA and near-infrared (NIR) dyes were conjugated to holo-Transferrin (Tf) sequentially, the result of ICP-AES and UV showed 25 Gd ions and 1 Cy5.

Highly luminescent and photostable near-infrared fluorescent polymer dots for long-term tumor cell tracking in vivo.

Near-infrared-emitting polymer dots were prepared by encapsulating the dye NIR775 into the matrix of MEH-PPV dots using a nanoscale precipitation method, and their application for long-term tumor cell tracking in vivo is demonstrated for the first time.

Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles.

Ultrasmall sub-5 nm KGdF4 rare earth nanoparticles were synthesized as multifunctional probes for fluorescent, magnetic, and radionuclide imaging. The cytotoxicity of these nanoparticles in human glioblastoma U87MG and human non-small cell lung carcinoma H1299 cells was evaluated, and their application for in vitro and in vivo tumor targeted imaging has also been demonstrated.

Long-term-stable near-infrared polymer dots with ultrasmall size and narrow-band emission for imaging tumor vasculature in vivo.

Fluorescent nanoprobes have become one of the most promising classes of materials for cancer imaging. However, there remain many unresolved issues with respect to the understanding of their long-term colloidal stability and photostability in both biological systems and the environment. In this study, we report long-term-stable near-infrared (NIR) polymer dots for in vivo tumor vasculature imaging.

Robust H(infinity) output feedback control for a class of uncertain Lur'e systems with time-delays.

In this work, the analysis of robust stability and design of robust H infinity output feedback controllers for a class of Lur'e systems with both time-delays and parameter uncertainties were studied. A robust H infinity output feedback controller based on Linear Matrix Inequalities (LMIs) was developed to guarantee the robust stability and H infinity performance of the resultant closed-loop system. The presented design approach is based on the application of descriptor model transformation and Park's inequality for the bounding of cross terms and is expected to be less conservative compared to reported design methods.