Parent-child communication and educational anxiety: a longitudinal analysis based on the common fate model.

Background: In the face of family stress and emerging family problems, the transactional model of stress and coping provides new perspectives for solving stress problems in the family. This study integrates it with the common fate model to reveal new paths for coping with educational anxiety problems from the level of parent-child dichotomous interaction in the family environment, aiming to provide some theoretical and practical support for alleviating parents' education anxiety.

Methods: This study used a combination of interviews and questionnaires to stratify students and their parents from a public junior high school in Jinan City to participate in the study.

Hierarchical structures and magnetism of Co clusters: a perspective from integration of deep learning and a hybrid differential evolution algorithm.

Theoretically determining the lowest-energy structure of a cluster has been a persistent challenge due to the inherent difficulty in accurate description of its potential energy surface (PES) and the exponentially increasing number of local minima on the PES with the cluster size. In this work, density-functional theory (DFT) calculations of Co clusters were performed to construct a dataset for training deep neural networks to deduce a deep potential (DP) model with near-DFT accuracy while significantly reducing computational consumption comparable to classic empirical potentials. Leveraging the DP model, a high-efficiency hybrid differential evolution (HDE) algorithm was employed to search for the lowest-energy structures of Co ( = 11-50) clusters.

PAK1 inhibition increases TRIM21-induced PD-L1 degradation and enhances responses to anti-PD-1 therapy in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDA) is a common malignancy with a 5-year survival <10 %. Immunosuppressive tumor microenvironment (TME) plays a critical role in the progression of PDA. In recent years, programmed death-ligand 1 (PD-L1)/programmed cell death protein-1 (PD-1) blockade has emerged as a potent anti-tumor immunotherapy, while is yet to achieve significant clinical benefits for PDA patients.

Current Understanding of Marginal Grafts in Liver Transplantation.

End-stage liver disease (ESLD), stemming from a spectrum of chronic liver pathologies including chronic liver failure, acute cirrhosis decompensation and hepatocellular carcinoma, imposes a significant global healthcare burden. Liver transplantation (LT) remains the only treatment for ESLD. However, the escalating mortality on transplant waitlists has prompted the utilization of marginal liver grafts in LT procedures.

Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma: a multicenter cohort study in China.

Objective: Sex-specific differences are observed in various liver diseases, but the influence of sex on the outcomes of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains to be determined. This study is the first Chinese nationwide investigation of the role of sex in post-LT outcomes in patients with HCC.

Methods: Data for recipients with HCC registered in the China Liver Transplant Registry between January 2015 and December 2020 were analyzed.

A novel nomogram for prognosis stratification in salvage liver transplantation: a national-wide study with propensity score matching analysis in China.

Background: Salvage liver transplantation (SLT) has been reported to be an efficient treatment option for patients with recurrent hepatocellular carcinoma (HCC) after liver resection (LR). However, for recipients who underwent liver transplantation (LT) due to recurrent HCC after LR in China, the selection criteria are not well established.

Methods: In this study, data from the China Liver Transplant Registry (CLTR) of 4,244 LT performed from January 2015 to December 2019 were examined, including 3,498 primary liver transplantation (PLT) and 746 SLT recipients.

Incorporation of protein induced by vitamin K absence or antagonist-II into transplant criteria expands beneficiaries of liver transplantation for hepatocellular carcinoma: a multicenter retrospective cohort study in China.

Introduction: In order to maximize the utilization of precious donor liver, precisely determining potential hepatocellular carcinoma (HCC) candidates who will benefit from liver transplantation (LT) is essential. As a crucial diagnostic biomarker for HCC, protein induced by vitamin K absence or antagonist-II (PIVKA-II) has become one of the key indicators for assessing tumor recurrence risk after LT. This study aims to investigate the role of PIVKA-II in recipient selection and prognostic stratification.

Protein induced by vitamin K absence or antagonist II: Experience to date and future directions.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with high mortality. The realization of precision medicine in HCC relies upon efficient biomarkers. Protein induced by vitamin K absence or antagonist II (PIVKA-II) is an immature prothrombin with insufficient coagulation activity, overexpressing in HCC cells.

Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling.

Background: Hepatic ischemia-reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the reticulum in the cytoplasm and is essential for metabolism and inflammatory responses. However, its function in IR injury remains ambiguous.

ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1.

Background: Sorafenib resistance greatly reduces the efficacy of treatments in advanced hepatocellular carcinoma (HCC) patients, but the underlying mechanisms are not thoroughly understood. All-trans retinoic acid (ATRA), an anti-leukaemia agent, has attracted considerable attention due to its role in sensitizing cells to other anticancer treatments. We aimed to investigate the combined effect of ATRA and Sorafenib on HCC and the underlying mechanisms.

Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl efflux signaling pathway.

Background: Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targets to cure the progression of OA. The NOD-, LRR-,and pyrin domain-containing protein 3 (NLRP3) inflammasome in synovial macrophages participates in the pathological inflammatory process and treatment strategies targeting it are considered to be an effective approach for OA.

P-21 Activated Kinases in Liver Disorders.

The p21 Activated Kinases (PAKs) are serine threonine kinases and play important roles in many biological processes, including cell growth, survival, cytoskeletal organization, migration, and morphology. Recently, PAKs have emerged in the process of liver disorders, including liver cancer, hepatic ischemia-reperfusion injury, hepatitis, and liver fibrosis, owing to their effects in multiple signaling pathways in various cell types. Activation of PAKs promotes liver cancer growth and metastasis and contributes to the resistance of liver cancer to radiotherapy and chemotherapy, leading to poor survival of patients.

A mixed blessing for liver transplantation patients - Rapamycin.

Background: Liver transplantation (LT) is an effective treatment option for end-stage liver disease. Mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, are widely used post LT.

Data Sources: In this review, we focused on the anti-cancer activities and metabolic side effects of rapamycin after LT.

Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments.

Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Recent advances in research have improved our understanding of the pathogenesis of IRI.

Using ISU-GAN for unsupervised small sample defect detection.

Surface defect detection is a vital process in industrial production and a significant research direction in computer vision. Although today's deep learning defect detection methods based on computer vision can achieve high detection accuracy, they are mainly based on supervised learning. They require many defect samples to train the model, which is not compatible with the current situation that industrial defect sample is difficult to obtain and costly to label.

Shyness and depressive symptoms: a multiple mediation model involving core self-evaluations and sense of security.

Background: Depression is one of the most common mental health disorders among Chinese university students. Some depressed students are observed to be shy. Therefore, the current study aimed to verify the association of shyness and depression symptoms and explore how shyness is positively associated with depressive symptoms.

The Effect of Shyness on Adolescent Network Problem Behavior: The Role of Gender and Loneliness.

With the latest, rapid developments of the Internet, young people have become the main group in the online world. Congruently, Internet problem behaviors have shown a significant growth trend among adolescents. The present paper explores the factors affecting adolescents' problem network behavior from the perspective of their shyness, gender, and loneliness, and provides suggestions for guiding these young people toward using the network rationally.

The effects of violent video games and shyness on individuals' aggressive behaviors.

The general aggression model (GAM) has suggested that the interaction between person factors (e.g., personality variables) and situation factors (e.

Associations among shyness, interpersonal relationships, and loneliness in college freshmen: A longitudinal cross-lagged analysis.

This short-term longitudinal study examined the reciprocal associations among shyness, interpersonal relationships, and loneliness in a sample of 361 Chinese college freshmen (138 male students, mean age = 18.57 years). A fully cross-lagged panel design was used in which shyness, interpersonal relationships, and loneliness were assessed at three time points separated by 8 months.

Susceptibility of Shy Students to Internet Addiction: A Multiple Mediation Model Involving Chinese Middle-School Students.

Recent studies found that some personality traits (e.g., impulsivity, sensation seeking) are frequently related to Internet addiction.

Relationship Between Shyness and Generalized Pathological Internet Use Among Chinese School Students: The Serial Mediating Roles of Loneliness, Depression, and Self-Esteem.

The present study aimed to explore the mediating effects of loneliness, depression, and self-esteem on the association between shyness and generalized pathological Internet use (GPIU). A total of 5215 school students completed questionnaires regarding shyness, loneliness, depression, self-esteem, and GPIU (aged 11-23 years old, = 16.19, = 3.

Shyness and Learning Adjustment in Senior High School Students: Mediating Roles of Goal Orientation and Academic Help Seeking.

Learning maladjustment is a common phenomenon in the context of examination-oriented education system in china, especially among high school students who experience intense pressure when preparing for the national college entrance examination. Previous literature suggests that shyness may negatively affect ones' cognition, emotion, and behavioral performance and lead to academic and social maladjustment. Therefore, learning adjustment among shy high school students is a critical and practical point of inquiry.

Enhanced performance of tin halide perovskite solar cell by addition of lead thiocyanate.

Organic-inorganic hybrid halide perovskites have attracted great attention as a new type of photovoltaic materials. However, lead (Pb) perovskite solar cells (PSCs) would cause environmental pollution in future large-scale applications. Therefore, it is imperative to find environmentally-friendly metals to replace lead.