Publications by authors named "Fengnan Yu"
Article Synopsis
- The study focuses on the loss of intestinal barrier integrity during colitis, which is accompanied by oxidative stress, and highlights the healing potential of bone morphogenetic protein 7 (BMP 7).
- A novel hydrogel (HDP-BMP 7) has been developed to deliver BMP 7, mimicking natural gut mucus and specifically adhering to inflamed colonic tissue while responding to oxidative stress.
- In animal experiments, HDP-BMP 7 not only improved colitis symptoms and restored mucus and epithelial barriers but also enhanced gut flora diversity and activated key signaling pathways, suggesting its strong therapeutic potential for gut health.
Article Synopsis
- Oral mucositis (OM) is a serious side effect of cancer treatment, and existing management techniques offer limited healing.
- A new in situ gel-forming oil (LGF) has been developed to provide better treatment, featuring good adhesion and wetting properties on oral tissues, which helps it stay in place.
- The oil contains α-lipoic acid, which gradually releases to reduce oxidative stress, promotes healing in animal studies, and reduces harmful inflammation associated with OM.
Oxidative stress has long been known as a pathogenic factor of ulcerative colitis. Superoxide dismutase (SOD) has been demonstrated to mitigate gut mucosal injury via combating oxidative stress. Herein, we developed SOD-loaded multivesicular liposomes (S-MVLs) as sustained-release depot for ulcerative colitis treatment.
View Article and Find Full Text PDFThe disrupted oxidative redox homeostasis plays a critical role in the progress of ulcerative colitis (UC). Herein, hydrogel-forming viscous liquid (HSD) composed of cysteamine-grafted hyaluronic acid (HS) and superoxide dismutase (SOD) has been designed for UC. When the viscous HSD liquid was infused into colitis colon, SOD would convert the pathological superoxide (O) to hydrogen peroxides (HO), which was subsequently scavenged by HS.
View Article and Find Full Text PDFThe pathogenesis of ulcerative colitis (UC) is associated with the shedding of the gut mucus. Herein, inspired by the biological functions of mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment by integrating dihydrocaffeic acid-modified poloxamer as a thermosensitive material with hyaluronic acid (colitis-specific adhesive), epigallocatechin-3-gallate (antibacterial agent), and bioactive factors (KPV tripeptide and epidermal growth factor). PHE-EK presented good thermosensitive properties, as a flowable liquid at room temperature and gelled within 10 s when exposed to body temperature.
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- Montmorillonite (MMT) can restore gut barrier integrity, but it's not effective against reactive oxygen species (ROS) for colitis patients.
- Researchers created polydopamine-doped montmorillonite micro-sheets (PDA/MMT) that effectively scavenge various ROS and improve cell viability under oxidative stress.
- PDA/MMT showed significant therapeutic benefits in mice with ulcerative colitis, restoring gut mucosa and alleviating inflammation, making it a promising treatment strategy.
Ulcerative colitis (UC) is a chronic recurrent disease affecting the gastrointestinal tract especially colorectum. Keratinocyte growth factor (KGF) plays the vital roles in maintaining the colonic mucosal barrier. The poor stability and off-target of KGF were two hindering factors for its clinical application.
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