Publications by authors named "Fengna Ding"
Article Synopsis
- The study investigated the immune features and genomic differences between squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the cervix, involving 336 patients over several medical centers in China.
- Results showed that AC had more mutations linked to immunotherapy resistance, while SCC had higher tumor mutational burdens and better immune cell infiltration, particularly of CD4+ T cells.
- The findings suggest that SCC and AC have distinct genetic profiles, which may inform different treatment approaches for these cervical cancer subtypes.
This study was to investigate the expression of coactivator-associated arginine methyltransferase 1 (CARM1) and miR-16-5p in cervical cancer (CC), and explore their roles in radioresistance. Western blot and immunohistochemistry were used to detect the expression of CARM1 in tissues and cells. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of miR-16-5p.
View Article and Find Full Text PDFCervical cancer is one of the most common gynecological malignancies globally, Unfortunately, radiotherapy and chemotherapy are not effective at treating some cases of this disease, and the 5-year survival rate is only 40-50%. Cell division cycle 25A (CDC25A) has been shown to induce radioresistance in a variety of tumor cells, but the role of CDC25A in the radioresistance of cervical cancer has not been fully elucidated. Here, we report that CDC25A is highly expressed and miR-122-5p lowly expressed in cervical cancer tissues and cells.
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