AEBP1 Silencing Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating Neuron Ferroptosis and Microglia M2 Polarization Through PRKCA-PI3K-Akt Axis.

Cerebral ischemia/reperfusion injury is one of the main causes of neuronal damage. Neuron ferroptosis and microglia polarization are considered as critical processes during cerebral ischemia/reperfusion. Adipocyte enhancer-binding protein 1 (AEBP1) usually acts as a transcriptional repressor which is involved in various diseases.

Assessment of Serum Metabolism and Eicosanoid Profiling in Pediatric Asthma and Bronchiolitis via Liquid Chromatography-Mass Spectrometry.

Background: Asthma, a prevalent chronic inflammatory respiratory disease among children, was the focus of this study. Serum metabolism profiles were examined in patients diagnosed with both asthma and bronchiolitis by using ultra-high performance liquid chromatography-mass spectrometry.

Methods: In this study, the serum samples from three distinct groups-comprising patients diagnosed with asthma, bronchiolitis, and a healthy control group-underwent comprehensive non-targeted metabolomics analysis and targeted eicosanoid profiling.

Identifying patterns of sexual behaviors and PrEP uptake characteristics among MSM who were eligible for PrEP: A national cross-section study.

Men who have sex with men (MSM) are at a high risk of HIV infection and should be offered effective preventive measures, such as pre-exposure prophylaxis (PrEP). However, PrEP uptake among eligible MSM was not as high as desired. Diverse research findings on how risky sexual behaviors affect PrEP uptake highlight the necessity for a comprehensive investigation.

Significant insights from a National survey in China: PrEP awareness, willingness, uptake, and adherence among YMSM students.

Introduction: Few studies focused on the Pre-Exposure Prophylaxis (PrEP) -related aspects, and the applicability of prior evidence to young men who have sex with men (YMSM) students was unknown. This study aimed to assess the awareness, willingness, uptake, and adherence (AWUA) to PrEP among YMSM students in China and to explore the associated factors with these stages.

Methods: A cross-sectional survey with a sizable sample of 1151 was conducted among YMSM students aged 16 and above, who self-identified as men who have sex with men(MSM) and resided in mainland China between October 20 and December 20, 2021.

Cascade analysis of awareness, willingness, uptake and adherence with regard to PrEP among young men who have sex with men (YMSM) in China: A comparison between students and non-students.

Introduction: In China, young men who have sex with men (YMSM) are one of the groups most at risk of HIV/AIDS. The uptake of pre-exposure prophylaxis (PrEP) among YMSM has not been well documented. A cascade analysis of awareness, willingness, use and adherence with regard to PrEP was conducted separately among YMSM students and non-students.

gene polymorphism predicts PEGylated IFN-α treatment response in hepatitis B surface antigen-positive chronic hepatitis B patients.

Genetic polymorphism can affect the response to antiviral therapy of chronic hepatitis B (CHB) patients. The study examined the genetic association of the rs1800796 polymorphism with PEGylated IFN-α (PegIFN-α) treatment response in hepatitis B surface antigen (HBsAg)-positive CHB patients. Direct sequencing was done for the genotyping of the rs1800796 polymorphism in the serum of CHB patients.

Optimization of Cu/Sn Alloy Sputtering Process Based on Orthogonal Experimental Design Method.

The performance of supercapacitors is directly influenced by the conductivity of polypyrrole, which serves as the electrode material. In order to balance considerations of cost-effectiveness and conductivity, this study employs magnetron sputtering to fabricate a copper-tin alloy layer as the conductive layer for polypyrrole. The deposition of a copper-tin alloy film through magnetron sputtering has a significant impact on the polymerization effect of pyrrole as well as being a crucial factor influencing the performance of supercapacitors.

Generation of a monoclonal antibody against duck circovirus capsid protein and its potential application for native viral antigen detection.

Introduction: Duck circovirus (DuCV) infection is currently recognized as an important immunosuppressive disease in commercial duck flocks in China. Specific antibodies against DuCV viral proteins are required to improve diagnostic assays and understand the pathogenesis of DuCV infection.

Methods And Results: To generate DuCV-specific monoclonal antibodies (mAbs), a recombinant DuCV capsid protein without the first 36 N-terminal amino acids was produced in .

Structure Design and Characterization of 3D Printing System of Thermal Battery Electrode Ink Film.

In this paper, a 3D printing system for a thermal battery electrode ink film is set up and investigated based on the on-demand microdroplet ejection technology. The optimal structural dimensions of the spray chamber and metal membrane of the micronozzle are determined via simulation analysis. The workflow and functional requirements of the printing system are set up.

Imaging properties of microsphere superlenses with varying background refractive indices under inclined illumination.

Microsphere lenses can overcome the optical diffraction limit and can be used to observe features smaller than 200 nm under white light. Inclined illumination benefits from the second refraction of evanescent waves in the microsphere cavity, prohibiting the influence of background noise and improving the imaging resolution and quality of the microsphere superlens. Currently, there is a consensus that microspheres immersed in a liquid environment can improve imaging quality.

Dual-wavelength paired-pulse Tm:YAlO/Ho:LuLiF laser at 1944 and 2066 nm.

The dual-wavelength paired-pulse output of a compact self--switched : intra-cavity pumping : laser was first demonstrated experimentally. By exploiting the self--switching mechanism of : and the gain-switching operation of : in a cavity, the dual-wavelength paired pulses were robustly generated with the pulse energy of 29 µJ, pulse width of 2.5 µs at 1944 nm, pulse energy of 31 µJ, and pulse width of 338 ns at 2066 nm.

LncRNA TRHDE-AS1 and MiR-1275 as Promising Prognostic Biomarkers and Effects on Tumor Cell Progression in Gastric Cancer.

Gastric cancer is a common malignant tumor with a relatively poor prognosis after surgery. Non-coding RNA may serve as biomarkers for the progression and prognosis of various cancers. The clinical significance and biological function of lncRNA TRHDE-AS1 and miR-1275 in gastric cancer were assessed in this study.

High-Efficiency Carbon-based CsPbI Br Perovskite Solar Cells from Dual Direction Thermal Diffusion Treatment with Cadmium Halides.

In recent years, carbon-based CsPbI Br perovskite solar cells (PSCs) have attracted more attention due to their low cost and good stability. However, the power conversion efficiency (PCE) of carbon-based CsPbI Br PSCs is still no more than 16%, because of the defects in CsPbI Br or at the interface with the electron transport layer (ETL), as well as the energy level mismatch, which lead to the loss of energy, thus limiting PCE values. Herein, a series of cadmium halides are introduced, including CdCl , CdBr and CdI for dual direction thermal diffusion treatment.

miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2.

This study aimed to explore the regulatory mechanisms of miR-338-3p and matrix metalloproteinase-2 (MMP-2) in neuroblastoma. Putative target interaction regions of miR-338-3p on MMP-2 were predicted by miRcode and miRbase bioinformatics tools. Relative expression of miRNA-338-3p and MMP-2 in neuroblastoma tissues and GI-LI-N and SK-N-SH cells was determined by reverse transcription polymerase chain reaction experiment.

Development of a Colloidal Gold Immunochromatographic Assay for Duck Enteritis Virus Detection Using Monoclonal Antibodies.

Duck viral enteritis is a highly contagious and fatal disease of commercial waterfowl flocks. The disease occurs sporadically or epizootically in mainland China due to insufficient vaccinations. Early and rapid diagnosis is important for preventive intervention and the control of epizootic events in clinical settings.

Multiple 'omics'-analysis reveals the role of prostaglandin E2 in Hirschsprung's disease.

The etiology and pathogenesis of Hirschsprung's disease (HSCR) remain largely unknown. We examined colon tissues from three independent populations with a combined analysis of metabolomics, transcriptomics and proteomics to understand HSCR pathogenesis, according to which mouse model was used to examine prostaglandin E2 (PGE2) induced clinical presentation of HSCR. SH-SY5Y and SK-N-BE(2) cell lines were studied for PGE2 inhibited cell migration through EP2.

Carbon quantum dots derived from the extracellular polymeric substance of anaerobic ammonium oxidation granular sludge for detection of trace Mn(vii) and Cr(vi).

Carbon quantum dots (CQDs) were synthesized a hydrothermal method, in which extracellular polymeric substance (EPS) from anaerobic ammonium oxidation (anammox) granular sludge was used as a carbon precursor, while citric acid and ethylenediamine were applied as auxiliary carbon source and passivation agent, respectively. The synthesized CQDs, with orderly spherical shape and mean size of 7.15 nm, emitted blue fluorescent light under UV radiation of 365 nm.

Changes in the levels of IL-1β, cortisol and chromogranin A in saliva of subjects with occupational fatigue.

Changes in the levels of interleukin-1β (IL-1β), cortisol and chromogranin A (CgA) in saliva of subjects with occupational fatigue were investigated. Doctors in the Emergency Department were selected as research subjects. Saliva was collected before work (after full rest) and after work (≥24 h).

CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.

Background: Aging is the most important risk factor for prostate cancer (PCa), but how age contributes to PCa is poorly understood. Aging is characterized by low-grade systemic inflammation (i.e.

Characterization of Isolates from Diseased Poultry in Northern China between 2014 and 2018.

infection not only causes acute and chronic diseases in poultry flocks, but the infected poultry are among the most important reservoirs for a variety of serovars frequently transmitted to humans. This study aimed to investigate the occurrence of spp. in local poultry farms in China.

Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis.

Tembusu virus (TMUV) is a flavivirus responsible for panzootic outbreaks of severe egg-drop and fatal encephalitis of domestic waterfowl in China. Although TMUV can be attenuated by passaging, experimental evidence supporting the role of specific genetic changes in virulence attenuation is currently lacking. Here, we performed site-directed mutagenesis on five envelope (E) protein amino acid residues in accordance with the attenuated TMUV generated in our recent study.

Highly efficient removal of thallium(I) from wastewater via hypochlorite catalytic oxidation coupled with adsorption by hydrochar coated nickel ferrite composite.

In this study, tannery wastewater was used as carbon source to hydrothermally synthesize magnetic carbon-coated nickel ferrite composite (NiFeO@C), which was employed as a catalyst for thallium (Tl) oxidation by hypochlorite and simultaneously as an adsorbent for Tl removal from wastewater. Compared with NiFeO@C adsorption or hypochlorite oxidation alone, the combination of NiFeO@C and hypochlorite substantially enhanced the rate and efficiency of Tl(I) removal. In addition, this process was highly effective for Tl(I) removal over a wide pH range (6-12).

Zero-valent iron-manganese bimetallic nanocomposites catalyze hypochlorite for enhanced thallium(I) oxidation and removal from wastewater: Materials characterization, process optimization and removal mechanisms.

Nano zero-valent metals adsorption coupled with advanced oxidation for environmental pollutants removal has been gaining attention recently. In this study, zero-valent iron-manganese (nZVIM) bimetallic nanocomposites were prepared via one-pot borohydride reduction and coupled with hypochlorite (ClO) oxidation for enhanced thallium (Tl) removal from wastewater. Amorphous nZVIM nanoparticles were successfully synthesized, with a specific surface area of 106.