Publications by authors named "Fenglan Dong"
Axonemal dynein complexes are preassembled in the cytoplasm before their transport to cilia, but the mechanism of this process remains unclear. We now show that mice lacking Pih1d3, a PIH1 domain-containing protein, develop normally but manifest male sterility. Pih1d3(-/-) sperm were immotile and fragile, with the axoneme of the flagellum lacking outer dynein arms (ODAs) and inner dynein arms (IDAs) and showing a disturbed 9+2 microtubule organization.
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- The study investigates how fluid flow around the node in mouse embryos influences the left-right asymmetry of a gene called Cerl2.
- It reveals that the asymmetry is due to the selective decay of Cerl2 mRNA on the left side, driven by the leftward flow and specific regulatory mechanisms.
- Additionally, feedback loops involving Wnt proteins and Cerl2 create a bistable switch, enhancing the effect of the fluid flow and stabilizing the left-right difference in gene expression.
There is a close correlation between the interfacial activity and the adsorption of the surfactant at the interface, but the detailed molecular standard information was scarce. The interfacial activity of two traditional anionic surfactants sodium dodecyl benzene sulfonate (SDBS) and sodium oleate (OAS) were studied by experimental and computer simulation methods. With the spinning drop method and the suspension drop method, the interfacial tension of oil/aqueous surfactant systems was measured, and the influence of surfactant concentration and salinity on the interfacial tension was investigated.
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