Clonal transmission of bla-carrying ST196 Klebsiella pneumoniae isolates mediated by the IncN plasmid in China.

Objectives: To investigate the clinical and molecular epidemiological characteristics of bla-carrying Klebsiella pneumoniae in a tertiary hospital in China.

Methods: Ten carbapenem-resistant K. pneumoniae (CRKP) isolates carrying the bla gene were collected.

Pangenome analysis of Shewanella xiamenensis revealed important genetic traits concerning genetic diversity, pathogenicity and antibiotic resistance.

Background: Shewanella xiamenensis, widely distributed in natural environments, has long been considered as opportunistic pathogen. Recently, significant changes in the resistance spectrum have been observed in S. xiamenensis, due to acquired antibiotic resistance genes.

Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China.

Background: Recently, extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates have been increasingly detected and posed great challenges to clinical anti-infection treatments. However, little is known about extensively resistant hypervirulent P. aeruginosa (XDR-hvPA).

Biosynthesis of Silver Nanoparticles Using the Biofilm Supernatant of PA75 and Evaluation of Their Antibacterial, Antibiofilm, and Antitumor Activities.

Purpose: As an under-explored biomaterial, bacterial biofilms have a wide range of applications in the green synthesis of nanomaterials. The biofilm supernatant of PA75 was used to synthesize novel silver nanoparticles (AgNPs). BF75-AgNPs were found to possess several biological properties.

Metagenomic analysis reveals the short-term influences on conjugation of bla and microbiome in hospital wastewater by silver nanoparticles at environmental-related concentration.

Hospital wastewater contains large amounts of antibiotic-resistant bacteria and serves as an important reservoir for horizontal gene transfer (HGT). However, the response of the microbiome in hospital wastewater to silver remains unclear. In this study, the short-term impacts of silver on the microbiome in hospital wastewater were investigated by metagenome next-generation sequencing.

Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla and bla in a tertiary hospital in China.

Background: The prevalence of multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKP) has gradually increased. It poses a severe threat to human health.

Molecular and clinical characterization of hypervirulent isolates from individuals with urinary tract infections.

Despite being a significant public health concern, hypervirulent (hvKP) has rarely been investigated in urinary tract infections (UTIs). To investigate the molecular and clinical characterization of hvKP in UTIs, we collected strains and clinical data from patients with UTIs. HvKP was confirmed by virulence-related genes and the model and sequenced by next-generation sequencing.

Efficacy of chemoradiotherapy in survival of stage Ⅳ nasopharyngeal carcinoma and establishment of a prognostic model.

Objectives: The efficacy of chemoradiotherapy regimen in the treatment of stage Ⅳ nasopharyngeal carcinoma (Ⅳ NPC) is not clear. This retrospective study aimed to reveal the benefit of chemoradiotherapy in Ⅳ-NPC and to develop a survival prognostic model for the disease prediction.

Materials And Methods: The Surveillance, Epidemiology, and End Results (SEER) database at https://seer.

Acute Post-Cataract Endophthalmitis Due to : A Rare Case Report.

species are a class of opportunistic pathogenic fungi widely present in the environment that cause invasive diseases in hosts with normal or weak immune functions. Common infections include peritonitis, endocarditis, osteomyelitis, and skin infections of wounds after burns, whereas endophthalmitis is rarely reported. Here, we report acute post-cataract endophthalmitis caused by in China.

Characterization of Silver Resistance and Coexistence of Operon with Antibiotic Resistance Genes Among Gram-Negative Pathogens Isolated from Wound Samples by Using Whole-Genome Sequencing.

Purpose: Due to the extensive consumption of silver-containing compound, silver resistance spreads among gram-negative pathogens and is regarded as a great public problem. In this study, we investigated silver resistance mechanisms and antibiotic resistance genes co-harbored with operon among gram-negative pathogens isolated from wound samples.

Methods: A total of 193 strains of gram-negative pathogens were collected from wound samples between 2018 and 2020 in Xiangya hospital.

Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria.

Background: The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure. However, polymyxin B-heteroresistant isolates are rare in individuals living in the community. We report a polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae (hvKP) isolate from an individual in the community with asymptomatic bacteriuria.

Distribution, characterization, and antibiotic resistance of hypervirulent Klebsiella pneumoniae isolates in a Chinese population with asymptomatic bacteriuria.

Background: Asymptomatic bacteriuria (ASB) frequently occurs among all ages and may develop into urinary tract infections (UTIs). Hypervirulent Klebsiella pneumoniae (hvKP) has become a new threat to human health. In our study, we aimed to investigate the epidemiological characteristics of hvKP in population with ASB.

Characteristics of Staphylococcus aureus small colony variants isolated from wound specimen of a tertiary care hospital in China.

Background: Small colony variants (SCVs) of Staphylococcus aureus (S. aureus) frequently lead to chronic and recurrent infections, but they are always ignored and there are few researches on their clinical isolates. We intended to investigate the prevalence and characteristics of S.

Clonal Dissemination of Multiple Carbapenemase Genes in Carbapenem-Resistant Enterobacterales Mediated by Multiple Plasmids in China.

Background: Carbapenem-resistant Enterobacterales (CRE) are rapidly increasing worldwide in last two decades and lead few antibiotics for treatment. The molecular epidemiology of CRE in China was investigated to provide basis for clinical rational use of antibiotics and prevent its spread.

Methods: All CRE isolates in this study were collected from 11 hospitals from October 2015 to July 2018.