Publications by authors named "Fengjie Li"

Importance: The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) is unknown.

Objective: To determine whether the use of high-intensity NPPV vs low-intensity NPPV reduces the need for endotracheal intubation in patients with an acute exacerbation of COPD and hypercapnia.

Design, Setting, And Participants: Randomized clinical trial conducted at 30 general respiratory non-intensive care unit wards of Chinese hospitals from January 3, 2019, to January 31, 2022; the last 90-day follow-up was on April 22, 2022.

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Xinjiang Brown cattle are a unique and widely distributed breed of dual-purpose cattle in the Xinjiang area of China, whose milk production performance differs from Holstein cattle. It has been known that variations in bacterial species of the gastrointestinal tract influence milk protein, fat, and lactose synthesis. However, the microbiota differences between Xinjiang Brown and Holstein cattle are less known.

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Background: Artificial neural networks (ANNs) have been extensively used in the field of medicine. The present hypothesis-free study sought to use an ANN to identify the characteristic genes of cervical cancer (CC).

Methods: RNA sequencing profiles were obtained from the GSE7410, GSE9750, GSE63514, and GSE52903 datasets.

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The aging of microplastics (MPs) is extremely influenced by photochemically-produced reactive intermediates (PPRIs), which are mediated by natural photosensitive substances. Algal extracellular polymeric substances (EPS) can produce PPRIs when exposed to sunlight. Nonetheless, the specific role of EPS in the aging process of MPs remains unclear.

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Background: Demodex blepharitis (DB) is a common disease of the ocular surface. The characteristics of the bacterial community in eyelash roots after Demodex infestation are still unknown. Knowledge of the characteristics of the bacterial community of eyelash follicles in patients with DB can provide valuable insights for guiding the diagnosis and treatment of DB.

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Article Synopsis
  • * A study collected and analyzed 55 groundwater samples from Chennai's coastal region, measuring parameters like pH and trace metals (e.g., Mg, Zn, Pb) during the pre-monsoon and post-monsoon seasons.
  • * The findings reveal that human activities, especially from industries and power plants, significantly worsen the pollution levels, leading to excessive salinity and hardness in the water, making it poorly suited for drinking and irrigation.
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Climate change and regional air pollution have had significant proportional coherence and are collectively hazardous for the regional ecosystem. To conduct this present investigation, we obtained high-resolution remotely sensed datasets from 2001 to 2022. To estimate climate variation, we utilized Climate Hazard Group InfraRed Precipitation with Station Data Version 2.

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  • * Electrical resistivity measurement is a non-destructive method used to assess soil conditions and identify unstable areas by examining factors like water and salt content.
  • * The study involved creating soil samples with varied characteristics, conducting tests to analyze resistivity, and correlating these findings with actual saline soil issues in the region to enhance understanding and support infrastructure development.
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Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis. In the past decades, humanized mouse models (HMMs), that are mice engrafted with human cells or genes, have been widely used in different research areas including immunology, oncology, and virology. With advances of the development of immunodeficient mice, the engraftment, and reconstitution of functional human platelets in HMM permit studies of occurrence and development of platelet disorders including IT and treatment strategies.

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  • - The study investigates the effectiveness of three neuropsychological tests (MoCA, MMSE, ADAS-cog) for diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) in individuals over 65, as direct neuropathological confirmation isn't typically available.
  • - Results show that ADAS-cog has the highest diagnostic accuracy for identifying both AD and MCI, outperforming MoCA and MMSE in sensitivity and Youden's Index, especially for AD.
  • - The research concludes that ADAS-cog and MoCA are reliable tools for detecting AD and MCI due to AD, with the prevalence rates estimated at 20% for AD and 24.8% for MCI among the
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Radiation exposure arising from radiotherapy may induce rapid bone loss and an increase in the extent of bone resorption. Reactive oxygen species (ROS) caused by radiation exposure play a crucial role during the process of osteoclastogenesis. However, the pathological mechanisms underlying radiation-induced osteoclastogenesis have yet to be fully elucidated.

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In order to reduce contamination levels from diverse sources, it is important to understand the factors affecting the natural ecosystems that are impacted by coastal and marine pollution. In this study, we used GIS and remote sensing techniques to investigate and evaluate the distribution of heavy metals (Fe, Mn, Zn, Cr, Pb, Co, and Cu) in surface sediments along Tamil Nadu's East Coast (from Besant Nagar to Sathurangapattinam). The CF and Igeo of metals indicate that sediments contain no evidence of Fe, Mn, or Zn metal pollution in the sediments, with only mild contamination from Co, Cu, and Pb.

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The aim of the meta-analysis was to generate a more comprehensive understanding of the HFA-PEFF score in the diagnosis of heart failure with preserved ejection fraction (HFpEF) and to pose clues in the field of scientific and clinical practice. Electronic databases of PubMed, Web of Science, Cochrane Library, and Embase were systematically searched. Studies investigating the use of the HFA-PEFF score to diagnose HFpEF were included.

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Background: Pulmonary sepsis and abdominal sepsis have pathophysiologically distinct phenotypes. This study aimed to compare their clinical characteristics and predictors of mortality. Methods: In this multicenter retrospective trial, 1,359 adult patients who fulfilled the Sepsis-3 criteria were enrolled and classified into the pulmonary sepsis or abdominal sepsis groups.

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Despite low temperatures, poor nutrient levels and high pressure, microorganisms thrive in deep-sea environments of polar regions. The adaptability to such extreme environments renders deep-sea microorganisms an encouraging source of novel, bioactive secondary metabolites. In this study, we isolated 77 microorganisms collected by a remotely operated vehicle from the seafloor in the Fram Strait, Arctic Ocean (depth of 2454 m).

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Microplastics (MPs) are considered to influence the bioavailability of heavy metals through direct adsorption, but this neglects the distribution of heavy metal chemical speciation indirectly influenced by MPs by altering geochemical properties. The present study aims to explore the link between the fractionation distribution of cadmium (Cd) and changes in geochemical properties in sediments induced by polyethylene terephthalate microplastics (PET-MPs). The PET-MPs reduced the acid-soluble fraction of Cd in sediments and increased its organically bound fraction.

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Photoaging is an important reaction for waste plastics in the aquatic environment and plays a key role in the lifetime of plastics. Nevertheless, when natural photosensitive substances such as nitrate participate in this process, the physiochemical changes in plastics and the corresponding reaction mechanisms are not well-understood. In this work, the photochemical behavior of polyethylene terephthalate (PET) bottles in deionized water and nitrate solution was systematically investigated under ultraviolet (UV) irradiation.

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Heavy metal pollution in urban soils and dust is mostly caused by extensive anthropogenic activity during urbanization and industrialization. In this research study, the pollution characteristics, sources, ecological and human health risks of heavy metals in urban soil, and dust have been thoroughly evaluated. The research findings demonstrate that dust has a higher level of contamination than urban soil, such as Pb, Cu, and Zn metals are more contaminated in both urban soil and dust throughout the city, and Hg and As are also found in locations with a high concentration of heavy industrial companies.

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Iron oxides play an important role in the transport and transformation of organic phosphorus in aquatic environments. However, the effect of different types of iron oxide on the environmental fate of organic phosphorus has remained unclear. In this study, the photodegradation of the organic phosphorus compound adenosine triphosphate (ATP) via the activity of crystalline (goethite) and amorphous (ferrihydrite) iron oxides was investigated.

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Ovarian cancer (OC) has the highest mortality rate among gynecological cancers, which progresses owing to dysregulated microRNAs (miRNAs) expression. Our study attempts to reveal the mechanism by which decreased miR-324-3p expression suppresses OC proliferation. Quantitative real-time PCR, western blotting, in situ hybridization, and immunohistochemistry were performed to estimate miR-324-3p and WNK2 expression levels in OC cells and tissues.

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Seaweed endophytic (algicolous) fungi are talented producers of bioactive natural products. We have previously isolated two strains of the endophytic fungus, sp. FVE-001 and FVE-087, from the thalli of the brown alga .

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Nanoplastics and metal oxide nanoparticles are serious threats that inevitably enter the environment. Their similar particle properties likely lead to interaction and thus cause more unpredictable ecotoxicity to organisms. In this study, it was found that polystyrene nanoplastics (PS NPs) aggravate the toxic effect of iron oxide nanoparticles (FeO NPs) on L.

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Background: Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) are neuropsychological tests commonly used by physicians for screening cognitive dysfunction of Alzheimer's disease (AD). Due to different imperfect reference standards, the performance of MoCA and MMSE do not reach consensus. It is necessary to evaluate the consistence and differentiation of MoCA and MMSE in the absence of a gold standard for AD.

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Irradiation disrupts the vascular niche where hematopoietic stem cells (HSCs) reside, causing delayed hematopoietic reconstruction. The subsequent recovery of sinusoidal vessels is key to vascular niche regeneration and a prerequisite for hematopoietic reconstruction. We hypothesize that resident bone marrow macrophages (BM-Mφs) are responsible for repairing the HSC niche upon irradiation injury.

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Abundant hybrid sediments composed of clastic rocks and carbonate rocks were deposited in the Devonian Yangmaba Formation in the northwestern of Sichuan Basin. Based on the measurement of the Ganxi section in detail, combined with the observation of the 30 slices, the hybrid facies, and hybrid sequence, the hybrid deposit mechanism and its controlling factors of the Yangmaba Formation were analyzed. It shows that the hybrid facies consists of the hybrid shore at the lower and clastic hybrid shelf and carbonate hybrid shelf deposits at the middle-upper of the Yangmaba Formation.

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