Role of inflammatory mediators in intracranial aneurysms: A review.

The formation, growth, and rupture of intracranial aneurysms (IAs) involve hemodynamics, blood pressure, external stimuli, and a series of hormonal changes. In addition, inflammatory response causes the release of a series of inflammatory mediators, such as IL, TNF-α, MCP-1, and MMPs, which directly or indirectly promote the development process of IA. However, the specific role of these inflammatory mediators in the pathophysiological process of IA remains unclear.

Effectiveness of MEP and SSEP Monitoring in the Diagnosis of Neurological Dysfunction Immediately After Craniotomy Aneurysm Clipping.

Objective: To explore the diagnostic accuracy of motor-evoked potential (MEP) and somatosensory-evoked potential (SSEP) monitoring in predicting immediate neurological dysfunction after craniotomy aneurysm clipping.

Methods: A total of 184 patients with neurosurgery aneurysms in the Affiliated Hospital of Qingdao University from April 2019 to December 2021 were retrospectively included. All patients underwent craniotomy aneurysm clipping, and MEP and SSEP were used to monitor during the operation.

Predictive value of neurophysiological monitoring during posterior communicating artery aneurysm clipping for postoperative neurological deficits.

Objective: This study aimed to evaluate the diagnostic effect of intraoperative neurophysiological monitoring in identifying intraoperative ischemic events and predicting postoperative neurological dysfunction during PCoA aneurysm clipping, as well as to explore the safe duration of intraoperative temporary clipping of the parent artery.

Methods: All 71 patients with PCoA aneurysm underwent craniotomy and aneurysm clipping. MEP and SSEP were used for monitoring during operation to evaluate the influence of MEP/SSEP changes on postoperative neurological function.

The Confinement-Affected Strength Variety of Anisotropic Rock Mass.

It has been recognized that the anisotropic structures dominate the deformation and strength properties of laminated rock masses. The resultant strength anisotropy is strongly affected by confining pressures beyond anisotropic structures. Nevertheless, the effects of confinement are inconsistent among existing experiments and not fully understood.

Pathogenic Factors and Prognosis of De Novo Aneurysms After Aneurysm Clipping.

Objective: To confirm this hypothesis, this study aimed to explore the pathogenic factors, prognosis, and their relationship in de novo aneurysms and to reach a consensus on their management.

Methods: First, the clinical data of 5 patients with de novo aneurysms from April 1998 to October 2021 were analyzed retrospectively. Then, the English literature on de novo aneurysms reported in Pubmed from 1985 to 2021 was systematically reviewed, and 18 case reports from 17 articles and 16 case series were identified.

ROC Curve Analysis of Electrophysiological Monitoring and Early Warning During Intracranial Aneurysm Clipping.

Objective: To explore the safe duration of temporary clipping of the parent artery under intraoperative electrophysiological monitoring.

Methods: The clinical data of 97 patients who underwent intracranial aneurysm clipping under electrophysiological monitoring in the Department of Neurology, Affiliated Hospital of Qingdao University from June 2019 to June 2020 were retrospectively analyzed. The safety duration of temporary clipping was analyzed using receiver operating characteristic (ROC) curves, and the results were validated in clinical data.

Ataxia telangiectasia-mutated gene polymorphisms and acute normal tissue injuries in cancer patients after radiation therapy: a systematic review and meta-analysis.

Purpose: Studies of the association between ataxia telangiectasia-mutated (ATM) gene polymorphisms and acute radiation injuries are often small in sample size, and the results are inconsistent. We conducted the first meta-analysis to provide a systematic review of published findings.

Methods And Materials: Publications were identified by searching PubMed up to April 25, 2014.