NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression.

Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology. Here, we demonstrate that knockout of Npc1 in hepatocytes attenuates hepatocellular carcinoma (HCC) progression in both DEN (diethylnitrosamine)-CCl induced and MYC-driven HCC mouse models. Mechanistically, NPC1 significantly promotes HCC progression by modulating the TGF-β pathway, independent of its traditional role in cholesterol transport.

Novel combination of bioleaching and persulfate for the removal of heavy metals from metallurgical industry sludge.

The objective of this study was to remove heavy metals from metallurgical industry sludge by bioleaching alone and bioleaching combined with persulfate (PDS). The results showed that the removal of Cu, Zn, Pb, and Mn reached 70%, 83.8%, 25.

Cattail fibers as source of cellulose to prepare a novel type of composite aerogel adsorbent for the removal of enrofloxacin in wastewater.

In this study, cattail was researched as a natural cellulose source to extract cellulose. Dewaxing, alkali and bleaching treatments were carried out for the cattail fibers (CFs). The FTIR, SEM and XRD results indicated that hemicellulose and lignin were successfully removed from the CFs, and the content of cattail cellulose increased from 41.