An Audio-Visual Speech Separation Model Inspired by Cortico-Thalamo-Cortical Circuits.

Audio-visual approaches involving visual inputs have laid the foundation for recent progress in speech separation. However, the optimization of the concurrent usage of auditory and visual inputs is still an active research area. Inspired by the cortico-thalamo-cortical circuit, in which the sensory processing mechanisms of different modalities modulate one another via the non-lemniscal sensory thalamus, we propose a novel cortico-thalamo-cortical neural network (CTCNet) for audio-visual speech separation (AVSS).

Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.

The inferior colliculus (IC) represents a crucial relay station in the auditory pathway, located in the midbrain's tectum and primarily projecting to the thalamus. Despite the identification of distinct cell classes based on various biomarkers in the IC, their specific contributions to the organization of auditory tectothalamic pathways have remained poorly understood. In this study, we demonstrate that IC neurons expressing parvalbumin (IC) or somatostatin (IC) represent two minimally overlapping cell classes throughout the three IC subdivisions in mice of both sexes.

Chromosomal microarray analysis for prenatal diagnosis of uniparental disomy: a retrospective study.

Background: Chromosomal microarray analysis (CMA) is a valuable tool in prenatal diagnosis for the detection of chromosome uniparental disomy (UPD). This retrospective study examines fetuses undergoing invasive prenatal diagnosis through Affymetrix CytoScan 750 K array analysis. We evaluated both chromosome G-banding karyotyping data and CMA results from 2007 cases subjected to amniocentesis.

A common thalamic hub for general and defensive arousal control.

The expression of defensive responses to alerting sensory cues requires both general arousal and a specific arousal state associated with defensive emotions. However, it remains unclear whether these two forms of arousal can be regulated by common brain regions. We discovered that the medial sector of the auditory thalamus (ATm) in mice is a thalamic hub controlling both general and defensive arousal.

Brain-wide inputs to the non-lemniscal inferior colliculus in mice.

The inferior colliculus (IC) is the hub along the auditory pathway. Although it is fundamentally an auditory structure, the neurons in the IC, especially its non-lemniscal part also respond to multimodal stimuli. However, the sources of these non-auditory inputs are unclear.

Fast operando spectroscopy tracking in situ generation of rich defects in silver nanocrystals for highly selective electrochemical CO reduction.

Electrochemical CO reduction (ECR) is highly attractive to curb global warming. The knowledge on the evolution of catalysts and identification of active sites during the reaction is important, but still limited. Here, we report an efficient catalyst (Ag-D) with suitable defect concentration operando formed during ECR within several minutes.

Health evaluation on migration and distribution of heavy metal Cd after reclaimed water drip irrigation.

The utilization of reclaimed water is one of the effective measures to save water resources. The study of reclaimed water irrigation and the analysis of how heavy metals migrate in the soil, especially their movement laws, have important theoretical and practical significance. It helps to predict the risk of heavy metals in foods, which protects our health and safety.

Responses of Ecosystem Services to Urbanization-Induced Land Use Changes in Ecologically Sensitive Suburban Areas in Hangzhou, China.

Ecologically sensitive suburban areas provide important ecosystem services and protect urban ecological security because of their multiple functions in natural and human systems. The research on the ecological environment effects of land use activities in ecologically sensitive suburban areas is important in guiding the healthy and sustainable development of cities. Taking the west suburbs of Hangzhou in China as a case study, we quantified land use changes from Landsat satellite imagery and calculated the value of ecosystem services using the well-established equivalent factor table for land use/cover change (LUCC) and ecosystem services value (ESV).

Distinct Anatomical Connectivity Patterns Differentiate Subdivisions of the Nonlemniscal Auditory Thalamus in Mice.

Systematic examination of the inputs and outputs of the nonlemniscal auditory thalamus will facilitate the functional elucidation of this complex structure in the central auditory system. In mice, comprehensive tracing studies that reveal the long-range connectivity of the nonlemniscal auditory thalamus are lacking. To this end, we used Cre-inducible anterograde and monosynaptic retrograde viruses in Calbindin-2A-dgCre-D and Calretinin-IRES-Cre mice, focusing on the differences across subdivisions of the nonlemniscal auditory thalamus.

Fast Inhibitory Decay Facilitates Adult-like Temporal Processing in Layer 5 of Developing Primary Auditory Cortex.

The protracted maturational process of temporal processing in layer 4 (L4) of primary auditory cortex (A1) has been extensively studied. Accumulating evidences show that layer 5 (L5) receives direct thalamic inputs as well. How the temporal responses in L5 may developmentally emerge remains unclear.

A Critical Role of Inhibition in Temporal Processing Maturation in the Primary Auditory Cortex.

Faithful representation of sound envelopes in primary auditory cortex (A1) is vital for temporal processing and perception of natural sounds. However, the emergence of cortical temporal processing mechanisms during development remains poorly understood. Although cortical inhibition has been proposed to play an important role in this process, direct in-vivo evidence has been lacking.