Publications by authors named "Fenghong Yuan"
Article Synopsis
- The study investigates the effectiveness and safety of a triple-combination therapy (high-dose corticosteroids, tacrolimus, and intravenous cyclophosphamide) for patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) who have interstitial lung disease (ILD).
- Despite hopes for positive outcomes, the therapy did not improve patient prognosis and was associated with higher mortality, particularly in high-risk patients with rapidly progressive ILD (RP-ILD).
- The findings indicate that this treatment may not be beneficial for MDA5+ DM patients, highlighting the need for further research to find safer and more effective therapies for this condition.
Background: The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) is these patients' leading cause of death. We sought to develop prediction models for RP-ILD risk in anti-MDA5DM patients.
View Article and Find Full Text PDFObjective: The aim is to investigate the clinical characteristics of systemic lupus erythematosus with intracranial hypertension.
Methods: The clinical characteristics of one case of systemic lupus erythematosus with chronic persistent intracranial hypertension were analyzed, and related literature was reviewed by searching Medline and Wanfang databases.
Results: Intracranial hypertension in SLE patients may occur at the onset or during the course of the disease.
Objective: To investigate the impact of sex differences on the clinical characteristics and prognosis of patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 DM).
Methods: We retrospectively analyzed a cohort of 251 patients with MDA5 DM, including 71 in the male group and 180 in the female group. A multivariate logistic regression model was built to analyze independent risk factors for RPILD in each group.
Background: Fever is a common symptom of Idiopathic inflammatory myopathies (IIM). However, the exact correlation between fever and the prognosis of IIM is still unclear. This study aims to clarify if the IIM patients initiated with fever are associated with poorer outcomes.
View Article and Find Full Text PDFBackground: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease mainly mediated by IgG autoantibody. While follicular helper T (Tfh) cells are crucial for supporting IgG autoantibody generation in human SLE, underlying mechanisms for Tfh cell mal-differentiation remain unclear.
Methods: In total, 129 SLE patients and 37 healthy donors were recruited for this study.
Background: In patients with systemic lupus erythematosus (SLE), myocardial involvement is the third leading course of death after lupus nephropathy (LN) and infections. Previous autopsy studies have demonstrated a high incidence of cardiovascular abnormalities in the myocardium. However, the patients with typical symptoms are far much fewer than expected from post-mortem examinations.
View Article and Find Full Text PDFObjective: to investigate the clinical characteristics of systemic lupus erythematosus with diffuse intracranial calcification.
Methods: The clinical characteristics of one case of systemic lupus erythematosus with diffuse intracranial calcification were analyzed, and 12 cases in related literatures were reviewed by searching Medline and Wanfang database.
Results: Our case and 12 cases reviewed were all female.
Objectives: Anti-melanoma differentiation-associated gene 5 positive (anti-MDA5+) DM has a close relationship with rapidly progressive interstitial lung disease (RPILD) and is associated with high mortality. However, data regarding the time-dependent risk of RPILD and deaths during disease progression are limited. We conducted this study to investigate whether the risk of RPILD and death were time-dependent or not in anti-MDA5+ DM.
View Article and Find Full Text PDFObjective: There is substantial heterogeneity among the phenotypes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM), hindering disease assessment and management. This study aimed to identify distinct phenotype groups in patients with anti-MDA5+ DM and to determine the utility of these phenotypes in predicting patient outcomes.
Methods: A total of 265 patients with anti-MDA5+ DM were retrospectively enrolled in the study.
Objective: Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in patients with dermatomyositis (DM) who are positive for antimelanoma differentiation-associated gene 5 antibody (anti-MDA5+). We conducted this study to investigate the association of anti-Ro52 antibodies with clinical characteristics and prognosis in patients with anti-MDA5+ DM.
Methods: We assessed a cohort of 246 patients with anti-MDA5+ DM.
Objectives: Our previous studies found that serum leptin was increased significantly in SLE, characterised by dysregulated autoreactive B cells producing excessive inflammatory cytokines and autoantibodies. The aim of this study was to explore the effects of leptin on B cell functions in SLE and clarify the key pathways in leptin dysregulated B cells.
Methods: Peripheral blood samples were obtained from 86 SLE patients and 28 normal controls.
Systemic sclerosis (SSc) associated with moyamoya syndrome (MMS) is a clinically rare disease. To further understand the clinical characteristics of SSc associated with MMS, we investigated and analyzed one case of SSc associated with MMS and conducted a literature review about this disease. Publications retrieved from MEDLINE and Wanfang databases were reviewed and discussed, and we found five well-described cases of SSc associated with MMS.
View Article and Find Full Text PDFBackground: A rapid and sensitive time-resolved fluoroimmunoassay (TRFIA) based on the biotin-streptavidin amplification system was developed for the determination of anticyclic citrullinated peptide (anti-CCP).
Methods: Europium-labeled streptavidin derivatives combined with europium and anhydride of diethylene triamine pentaacetic acid were used to label streptavidin, biotin was coupled with rabbit anti-human IgG to form a biotin-anti-human IgG bridge between streptavidin-europium and the anti-CCP antibody in the immunoassay. The anti-CCP assay was carried out by measuring the fluorescence of Eu(3+) -streptavidin at 615 nm.