Evolution law of surrounding rock stress field for ultra-deep shaft development blasting.

With the increase of the construction depth for ultra-deep shaft development blasting, it is prone to occur problems such as reduced driving efficiency, frequent dynamic disasters, wellbore instability and fracture under the coupling effect of deep high stress and strong blasting disturbance. In this paper, the dynamic evolution process of surrounding rock stress field and the propagation law of explosion stress wave in the process of ultra-deep shaft development blasting were studied by combining theoretical analysis with physical model test. The theoretical analysis model of ultra-deep shaft blasting excavation was established based on elastic mechanics, and the stress distribution and failure mechanism of surrounding rock under the coupling effect of deep high stress and blasting load were explored.

Identification of new immune subtypes of renal injury associated with anti-neutrophil cytoplasmic antibody-associated vasculitis based on integrated bioinformatics analysis.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease that may lead to end-stage renal disease. However, few specifific biomarkers are available for AAV-related renal injury. The aim of this study was to identify important biomarkers and explore new immune subtypes of AAV-related renal injury.

Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19.

Renal injury secondary to COVID-19 is an important factor for the poor prognosis of COVID-19 patients. The pathogenesis of renal injury caused by aberrant immune inflammatory of COVID-19 remains unclear. In this study, a total of 166 samples from 4 peripheral blood transcriptomic datasets of COVID-19 patients were integrated.