Machine learning identifies SLC6A14 as a novel biomarker promoting the proliferation and metastasis of pancreatic cancer via Wnt/β-catenin signaling.

Pancreatic cancer (PC) has the poorest prognosis compared to other common cancers because of its aggressive nature, late detection, and resistance to systemic treatment. In this study, we aimed to identify novel biomarkers for PC patients and further explored their function in PC progression. We analyzed GSE62452 and GSE28735 datasets, identifying 35 differentially expressed genes (DEGs) between PC specimens and non-tumors.

Production, Biosynthesis, and Commercial Applications of Fatty Acids From Oleaginous Fungi.

Oleaginous fungi (including fungus-like protists) are attractive in lipid production due to their short growth cycle, large biomass and high yield of lipids. Some typical oleaginous fungi including , and , have been well studied for the ability to accumulate fatty acids with commercial application. Here, we review recent progress toward fermentation, extraction, of fungal fatty acids.

Characterization of a New Intracellular Alginate Lyase with Metal Ions-Tolerant and pH-Stable Properties.

Alginate lyases play an important role in alginate oligosaccharides (AOS) preparation and brown seaweed processing. Many extracellular alginate lyases have been characterized to develop efficient degradation tools needed for industrial applications. However, few studies focusing on intracellular alginate lyases have been conducted.

Optical design and fabrication of an all-aluminum unobscured two-mirror freeform imaging telescope.

Freeform optics offers more degrees of freedom to optical design that can benefit from a compact package size and a large field of view for imaging systems. Motivated by the advances in modern optical fabrication and metrology, freeform optics has been found in many applications. In this paper, we will describe the challenging optical design, fabrication, metrology, and assembly of an all-aluminum unobscured two-mirror freeform imaging telescope.

Fast design method of smooth freeform lens with an arbitrary aperture for collimated beam shaping.

A method is presented for the fast design of a smooth freeform lens to tailor a collimated light beam with an arbitrary contour. This method begins by calculating an initial surface based on a simplified ray mapping. Then the surface is fitted by a system of Zernike polynomials, whose weights are treated as the optimization variables for further optimization.

Gastric carcinoma with a gastrointestinal stromal tumor - A case report and literature review.

Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection.

The diagnosis and treatment of traumatic retroperitoneal hematoma.

Objective: To analyze our experiences in patients with traumatic retroperitoneal hematoma, and highlight the problems in diagnosis and treatment to facilitate the surgeons to make decision.

Methodology: One hundred and eight patients of traumatic retroperitoneal hematoma treated in our institution from May 2008 to Jun 2012 were reviewed retrospectively. The data including patient's age, type of injury, hospital stays, type of treatment, injured organs and mortality rate were collected.