Enterotoxin-related genes PPFIA4 and SCN3B promote colorectal cancer development and progression.

To identify the role of enterotoxin-related genes in colorectal cancer (CRC) development and progression. Upregulated differentially expressed genes shared by three out of five Gene Expression Omnibus (GEO) data sets were included to screen the key enterotoxin-induced oncogenes (EIOGs) according to criteria oncogene definition, enrichment, and protein-protein interaction (PPI) network analysis, followed by prognosis survival, immune infiltration, and protential drugs analyses was performed via integration of RNA-sequencing data and The Cancer Genome Atlas-derived clinical profiles. We screened nine common key EIOGs from at least three GEO data sets.

Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.

Background: Xuebijing (XBJ) is widely applied in the treatment of Acute Lung Injury (ALI). This study focused on the potential mechanism of XBJ in Lipopolysaccharide (LPS)-induced ALI.

Methods: The rat ALI model was established by injection of LPS (10 mg/kg) and pretreated with XBJ (4 mL/kg) three days before LPS injection.

Enterotoxigenic Bacteroides fragilis (ETBF) Enhances Colorectal Cancer Cell Proliferation and Metastasis Through HDAC3/miR-139-3p Pathway.

Enterotoxigenic Bacteroides fragilis (ETBF) is believed to promote the malignant process of colorectal cancer (CRC), but the underlying molecular mechanism still needs to be revealed. CRC cells (SW480 and HCT-116) were treated with ETBF strain. Cell proliferation, invasion and, migration were evaluated by cell counting kit 8 assay, EdU assay, colony formation assay, transwell assay, and wound healing assay.

Comparison of detection strategies for screening and confirming congenital cytomegalovirus infection in newborns in a highly seroprevalent population: a mother-child cohort study.

Background: Universal screening of congenital cytomegalovirus (cCMV) infection is important for monitoring and intervention during critical stages of speech and language development. This study aimed to explore the optimal detection strategy for cCMV infection screening.

Methods: Serum samples from pregnant women and saliva and urine samples from their newborns were collected for the anti-CMV IgG and CMV DNA PCR tests, respectively.

Effect of aspirin use on survival benefits of breast cancer patients: A meta-analysis.

Objective: The purpose of this study is to investigate whether aspirin improves the prognosis of breast cancer patients by meta analysis.

Methods: Searched PubMed, EMBASE, and other databases for literature on the relationship between aspirin use and breast cancer prognosis, with the deadline of October 2019. The related results of all-cause death, breast cancer-specific death, and breast cancer recurrence/metastasis were extracted to combine the effect amount.

Efficacy, Safety, and Immunogenicity of an Escherichia coli-Produced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial.

Background: The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace of controlling cervical cancer. A phase III clinical trial was conducted to evaluate the efficacy, safety, and immunogenicity of a novel Escherichia coli-produced bivalent HPV-16/18 vaccine.

Methods: A multicenter, randomized, double-blind trial started on November 22, 2012 in China.

[Association between life style, diet intake and high risk-human papillomavirus persistent infection among rural women in Xinmi City, Henan Province].

Objective: To explore the association between life style, diet intake and high risk human papillomavirus (HR-HPV) persistent infection among Chinese rural women living in Xinmi City, Henan Province.

Methods: In 2010, a 3-year prospective study in which 2500 women were enrolled and screened by different HR-HPV DNA tests was conducted, part of women among them was followed and tested for HR-HPV DNA in 2012 and 2014. Furthermore, socio demographic factors, gynecological information and diet intake in the past 12 months were collected by self-designed questionnaire in 2014.

Simulation study on gold nanoparticle-cellular membrane complex in endocytosis process.

Gold nanoparticles (AuNPs) are of biomedical importance, such as delivery vectors. Therefore, we used all-atom molecular dynamic simulations to study the interaction of AuNPs with cell membrane (DMPC bilayer). We observed that the AuNPs adhered spontaneously on the surface of the cellular membrane from the bulk phase, largely as a result of the AuNP-DMPC headgroup attraction.

A Monte Carlo study of crowding effects on the self-assembly of amphiphilic molecules.

In this work, lattice Monte Carlo was used to study the effects of crowding on the self-assembly of surfactants. Simulation results show that crowding strongly shifts the critical micelle concentration (CMC) of surfactants from the bulk value. Two effects originated from crowding are found to govern the CMC shift: one is the depletion effect by crowding agents and the other is the available volume for micelle formation.

Stability and rupture of archaebacterial cell membrane: a model study.

It is known that the thermoacidophilic archaebacterium Sulfolobus acidocaldarius can grow in hot springs at 65-80 degrees C and live in acidic environments (pH 2-3); however, the origin of its unusual thermal stability remains unclear. In this work, using a vesicle as a model, we study the thermal stability and rupture of archaebacterial cell membrane. We perform a simulation investigation of the structure-property relationship of monolayer membrane formed by bolaform lipids and compare it with that of bilayer membrane formed by monopolar lipids.

Macrophase and microphase separations for surfactants adsorbed on solid surfaces: a gauge cell monte carlo study in the lattice model.

By combining the gauge cell method and lattice model, we study the surface phase transition and adsorption behaviors of surfactants on a solid surface. Two different cases are considered in this work: macrophase transition and adsorption in a single-phase region. For the case of macrophase transition, where two phases coexist, we investigate the shape and size of the critical nuclei and determine the height of the nucleation barrier.

Adsorption and morphology transition of surfactants on hydrophobic surfaces: a lattice Monte Carlo study.

In this work, we first show that there are only five independent interchange parameters in the surfactant-solvent-interface system in Larson's model, and then adsorption and morphology transition of surfactants on hydrophobic surfaces are studied by extensive lattice Monte Carlo simulations. In our simulations, we found that there exist six adsorbed morphologies: (1) premature admicelle, (2) hemisphere, (3) hemisphere-hemicylinder mixture, (4) wormlike hemicylinder, (5) perforated monolayer, and (6) monolayer. The surface morphologies and the amount of adsorption on hydrophobic surfaces are found to be affected obviously by two interchange parameters.