Revealing the underestimated role of Gram-positive bacteria in iron reduction within paddy soils.

Iron reduction in paddy fields is crucial for heavy metal migration and nutrient transformation. Gram-negative iron-reducing bacteria like Geobacter and Shewanella have been widely studied due to their strong extracellular electron transfer capabilities. In contrast, Gram-positive bacteria such as Bacillus and Clostridium are often labeled as weak exoelectrogens, leading to their contributions being overlooked.

Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats.

Introduction: Blood proteomics offers a powerful approach for identifying disease-specific biomarkers. However, no reliable blood markers are currently available for the diagnosis stroke. Nervonic acid (NA), a vital long-chain monounsaturated fatty acid found in mammalian nervous tissue, shows promising therapeutic potential in neurological disorders.

Preparation of ZnAl layered double hydroxides supported by silica for the treatment of Cr(VI) and Cu(II) in aqueous solution.

A novel adsorbent ZnAl-LDHs/SiO (ZA/SiO) was prepared by blending urea mixture of ZnSO and Al(SO) while using SiO as a support form. The adsorption properties of ZA/SiO for the removal of toxic metal ions (Cu(II) and Cr(VI)) from water were evaluated. By batch experiment method to investigate the ZA/SiO adsorption of Cu(II) and Cr(VI) solution treatment effect.

[Proteomics in prevention and treatment of post-myocardial infarction heart failure diseases with traditional Chinese medicine].

Myocardial infarction(MI) is a cardiovascular disease with high disability and mortality rates in clinical practice, which can subsequently develop into complications such as heart failure(HF) or cardiac rupture. Proteomics can track changes in relevant functional molecules during the occurrence and progression of diseases from an overall, molecular, systematic, and flux perspectives. Utilizing proteomic techniques to deeply explore the functional targets, molecular mechanisms, and network effects of MI and HF can aid in early diagnosis, early warning, and drug treatment of these diseases.

Bailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice.

Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) has shown notable effectiveness and safety in managing illnesses linked to cytokine storm(CS). Bailixiang tea (BLX), an herbal medicine formula, which is a compound Chinese medicine composed of Thymus mongolicus (Ronniger) Ronniger (Bailixiang), Glycyrrhiza uralensis Fisch. (Gancao), Citrus reticulata Blanco (Chenpi), Cyperus rotundus L.

One-Pot Preparation of Layered Double Hydroxide-Engineered Boric Acid Root and Application in Wastewater.

Heavy metals and organic pollutants are prevalent in water bodies, causing great damage to the environment and human beings. Hence, it is urgent to develop a kind of adsorbent with good performance. Anion interlacing layered double hydroxides (LDHs) are a promising adsorbent for the sustainable removal of heavy metal ions and dyes from wastewater.

Dual Effect by Chemical Electron Transfer Enhanced siRNA Lipid Nanoparticles: Reactive Oxygen Species-Triggered Tumor Cell Killing Aggravated by Nrf2 Gene Silencing.

Insufficient endosomal escape presents a major hurdle for successful nucleic acid therapy. Here, for the first time, a chemical electron transfer (CET) system was integrated into small interfering RNA (siRNA) lipid nanoparticles (LNPs). The CET acceptor can be chemically excited using the generated energy between the donor and hydrogen peroxide, which triggers the generation of reactive oxygen species (ROS), promoting endosomal lipid membrane destabilization.

Unraveling patterns, causes, and nature-based remediation strategy for non-grain production on farmland in hilly regions.

The surge in non-grain production on farmland (NGPF) poses significant threats to food security and land sustainability, particularly in hilly regions. However, there remains a lack of clarity on how to effectively balance grain and non-grain production in relation to land remediation. Using Wannian County as a case study, we investigate the evolution of this by leveraging high-precision land surveys and satellite imagery.

Effect of pH on the ozonolysis degradation of p-nitrophenol in aquatic environment and the synergistic effect of hydroxy radical.

Density functional theory (DFT) was employed to elucidate the mechanisms for ozonolysis reaction of p-nitrophenol (PNP) and its anion form aPNP. Thermodynamic data, coupled with Average Local Ionization Energies (ALIE) analysis, reveal that the ortho-positions of the OH/O groups are the most favorable reaction sites. Moreover, rate constant calculations demonstrate that the O attack on the C2-C3 bond is the predominant process in the reaction between neutral PNP and O.

Xinshubao tablet rescues cognitive dysfunction in a mouse model of vascular dementia: Involvement of neurogenesis and neuroinflammation.

Vascular dementia (VaD) represents a severe cognitive dysfunction syndrome closed linked to cardiovascular function. In the present study, we assessed the potential of Xinshubao tablet (XSB), a traditional Chinese prescription widely used for cardiovascular diseases, to mitigate neuropathological damage in a mouse model of VaD and elucidated the underlying mechanisms. Our findings revealed that oral administration of XSB rescued the cardiac dysfunction resulting from bilateral common carotid artery stenosis (BCAS), improved the cerebral blood flow (CBF) and cognitive function, reduced white matter injury, inhibited excessive microglial and astrocytic activation, stimulated hippocampal neurogenesis, and reduced neural apoptosis in the brains of BCAS mice.

Preparation of MgAl-LDHs loaded with blast furnace slag and its removal of Cu(II) and methylene blue from aqueous solution.

Blast furnace slag (BFS) is a kind of waste produced in industrial production, as well as a valuable secondary resource. In this paper, layered double hydroxides composites (BFS/LDHs) were prepared by aqueous polymerization, with industrial waste BFS as modifier and magnesium nitrate, aluminium nitrate, and urea as raw materials. BFS/LDHs have been characterized by using scanning electron microscopy (SEM), fourier infrared spectrometer (FT IR), x-ray diffraction (XRD), and the specific surface area analyser (BET).

Visible-Light-Induced and Iodoform-Promoted Functionalization of Ether with Secondary Sulfonyl Amides.

An iodoform-promoted functionalization of ether with secondary sulfonyl amides under visible-light irradiation was developed toward synthesis of hemiaminal skeleton with good to excellent isolated yields. The characterization of the isolated ether and iodoform complex revealed regioselective hydrogen atom transfer to initiate carbon radical formation and enabled the amination reaction with the sulfonamide.

Receptor-Targeted Carbon Nanodot Delivery through Polymer Caging and Click Chemistry-Supported LRP1 Ligand Attachment.

Carbon nanodots present resistance to photobleaching, bright photoluminescence, and superior biocompatibility, making them highly promising for bioimaging applications. Herein, nanoprobes were caged with four-armed oligomers and subsequently modified with a novel DBCO-PEG-modified retro-enantio peptide ligand reL57, enhancing cellular uptake into U87MG glioma cells highly expressing low-density lipoprotein receptor-related protein 1 (LRP1). A key point in the development of the oligomers was the incorporation of ε-amino-linked lysines instead of standard α-amino-linked lysines, which considerably extended the contour length per monomer.

Cardioprotective efficacy of Xin-shu-bao tablet in heart failure with reduced ejection fraction by modulating THBD/ARRB1/FGF1/STIM1 signaling.

Traditional Chinese medicine offer unique advantages in mitigating and preventing early or intermediate stage for treating heart failure (HF). The purpose of this study was to assess the in vivo therapeutic efficacy of Xin-shu-bao (XSB) at different stages of HF following induction of a myocardial infarction (MI) in mice and use mass spectrometry-based proteomics to identify potential therapeutic targets for different stages of HF based on the molecular changes following XSB treatment. XSB had high cardioprotective efficacy in the pre-HF with reduced ejection fraction (HFrEF) stages, but had a weak or no effect in the post-HFrEF stages.

Preparation of hydrogels based on poplar cellulose and their removal efficiency of Cd(II) from aqueous solutions.

Industrial heavy metal-contaminated wastewater is one of the main water pollution problems. Adsorbents are a promising method for the removal of heavy metal contaminants. Herein, polyaspartic acid/carboxymethyl poplar sawdust hydrogels (PASP/CMPP) and ascorbic acid/carboxymethyl poplar sawdust hydrogels (VC/CMPP) were prepared by aqueous polymerization using alkalized poplar sawdust (CMPP) as the substrate and PASP and vitamin C (VC) as modifiers.

A nitrogen fixing symbiosis-specific pathway required for legume flowering.

Symbiotic nitrogen fixation boosts legume growth and production in nitrogen-poor soils. It has long been assumed that fixed nitrogen increases reproductive success, but until now, the regulatory mechanism was unknown. Here, we report a symbiotic flowering pathway that couples symbiotic and nutrient signals to the flowering induction pathway in legumes.

Preparation of a High-Temperature Soybean Meal-Based Adhesive with Desired Properties via Recombination of Protein Molecules.

A soybean protein-based adhesive with desired adhesion properties and low processing cost is prepared by a simple and practical method, which is of great significance to the sustainable utilization of resources and human health. Nevertheless, the protein of high-temperature soybean meal (HSM) has a high degree of denaturation and low solubility, endowing the resultant soybean-based adhesive with a high viscosity and unstable bonding performance. Herein, we propose the strategy of protein molecular recombination to improve the bonding properties of the adhesive.

Research on the effect and underlying molecular mechanism of Cangzhu in the treatment of gouty arthritis.

Objective: We aimed to identify the active ingredients and elucidate the underlying mechanism of action of Atractylodes lancea (Thunb.) DC (namely, Cangzhu) for the treatment of gouty arthritis (GA) based on network pharmacology methods. These findings are expected to provide a theoretical basis for the clinical treatment of GA.

Endothelium-dependent vasorelaxant effects of praeruptorin a in isolated rat thoracic aorta.

Praeruptorin A (PA) is a natural coumarin compound from the roots of Radix Peucedani and is commonly used in the treatment of certain respiratory diseases and hypertension. Although previous studies identified relaxant effects of PA on tracheal and arterial preparations, little is known about its vasodilative effects and underlying mechanisms. Here, an organ bath system and tension recording methods were used to prepare and analyze isolated rat thoracic aorta artery rings.

Visible-Light-Mediated Three-Component Radical Iodosulfonylative Cyclization of Enynes.

An efficient three-component radical iodosulfonylative cyclization of enynes is described. The visible-light irradiation of iodoform with sulfinates enables sulfonyl radical generation under catalyst- and oxidant-free conditions and triggers the radical addition, cyclization and iodination cascade reactions, giving various vinyl iodide containing sulfones in moderate to good yields.

[Core prescriptions in treatment of edema by traditional Chinese medicine masters and mechanism prediction].

The core prescriptions and formulation characteristics in the treatment of edema by traditional Chinese medicine(TCM) masters were analyzed through data mining and their mechanisms were explored by network pharmacology. We collected journal reports on the treatment of edema by TCM masters in three sessions from China National Knowledge Infrastructure(CNKI) and constructed a database by Traditional Chinese Medicine Inheritance Support System 3.0.

Significant loss of soil inorganic carbon at the continental scale.

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and CO release. However, to date, few studies have addressed these processes. Here, we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon (SIC) stocks in China.

The miR156b-GmSPL9d module modulates nodulation by targeting multiple core nodulation genes in soybean.

Symbiotic nodulation is initiated in the roots of legumes in response to low nitrogen and rhizobial signal molecules and is dynamically regulated by a complex regulatory network that coordinates rhizobial infection and nodule organogenesis. It has been shown that the miR156-SPL module mediates nodulation in legumes; however, conclusive evidence of how this module exerts its function during nodulation remains elusive. Here, we report that the miR156b-GmSPL9d module regulates symbiotic nodulation by targeting multiple key regulatory genes in the nodulation signalling pathway of soybean.

Surface Wettability of Nanoparticle Modulated Sonothrombolysis.

Sonodynamic therapy (SDT) is a non-invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles is investigated.