Extracellular acidification stimulates OGR1 to modify osteoclast differentiation and activity through the Ca2+‑calcineurin‑NFATc1 pathway.

The aim of the present study was to explore the role of ovarian cancer G protein-coupled receptor 1 (OGR1) in osteoclast differentiation and activity induced by extracellular acid. The impact of extracellular acidification on osteoclasts was investigated. Briefly, osteoclasts were generated from RAW 264.

Response of CH and NO emissions to the feeding rates in a pond rice-fish co-culture system.

Feeding rate is an important factor influencing the carbon and nitrogen input and greenhouse gas emission from aquaculture systems. However, the quantitative relationship between feeding rates and GHG emissions is still poorly understood. In this study, we conducted a laboratory-scale experiment to examine the impact of feeding rate (0%, 2%, 4%, 6%, and 8%) on the CH and NO emissions from a pond rice-fish co-culture system.

A polyoxometalate/chitosan-TiCT MXene nanocomposite constructed by electrostatically mediated strategy for electrochemical detecting L-tryptophan in milk.

L-tryptophan (L-Trp) is crucial for human metabolism, and its imbalance or deficiency can lead to certain diseases, such as insomnia, depression, and heart disease. Since the body cannot synthesize L-Trp and must obtain it from external sources, accurately monitoring L-Trp levels in food is essential. Herein, a nanocomposite film based on polyoxometalate (PMoV), TiCT MXene, and chitosan (Cs) was developed through a green electrostatically mediated layer-by-layer self-assembly strategy for electrochemical detection of L-Trp.

Genome-wide analysis reveals the contributors to fast molecular evolution of the Chinese hook snout carp ().

Variations in molecular evolutionary rate have been widely investigated among lineages and genes. However, it remains an open question whether fast rate of molecular evolution is driven by natural selection or random drift, and how the fast rate is linked to metabolic rate. Additionally, previous studies on fast molecular evolution have been largely restricted to concatenated matrix of genes or a few specifically selected genes, but less is known for individual genes at the genome-wide level.

Interface Engineering-Modulated Nanoscale Bimetallic CoFe-MIL-88A In-Situ-Grown on 2D VCT MXene for Electrocatalytic Nitrogen Reduction.

The electrochemical nitrogen reduction reaction (eNRR) provides a sustainable green development route for the nitrogen-neutral cycle. In this work, bimetallic CoFe-MIL-88A with two active sites (Fe, Co) were immobilized on a 2D VCT MXene surface by in situ growth method to achieve the purpose of the control interface. A large number of heterostructures are formed between small CoFe-MIL-88A and VCT, which regulate the electron transfer between the catalyst interfaces.

Facile design of FeCu metal-organic frameworks anchored on layer TiCT MXene for high-performance electrochemical sensing of resorcinol.

This work reports the rational design of a composite material by growing FeCu-MOF-919 on the surface of layered TiCT MXene. The introduction of TiCT MXene simultaneously weakens the aggregation of FeCu-MOF-919 and TiCT MXene, which increases the electrochemical reaction active site of the composite material and improves the electrochemical activity. Interestingly, the FeCu-MOF-919/TiCT based sensors were used to detect resorcinol (RS) with a wide linear range (0.

In-situ synthesized and induced vertical growth of cobalt vanadium layered double hydroxide on few-layered VCT MXene for high energy density supercapacitors.

Two-dimensional (2D) MXene nanomaterials display great potential for green energy storage. However, as a result of self-stacking of MXene nanosheets and the presence of conventional binders, MXene-based nanomaterials are significantly hindered in their rate capability and cycling stability. We successfully constructed a self-supported stereo-structured composite (TMA-VCT/CoV-LDH/NF) by in-situ growing 2D cobalt vanadium layered double hydroxide (CoV-LDH) vertically on 2D few-layered VCT MXene nanosheets and interconnecting it with Ni foam (NF) with a self-supported structure to act as a binder-free electrode.

Manganese-cobalt hydroxide nanosheets anchored on a hollow sulfur-doped bimetallic MOF for high-performance supercapacitors and the hydrogen evolution reaction in alkaline media.

Nonmetallic doping and growth techniques for designing electrode materials with excellent electrocatalytic activity are effective strategies to enhance the electrochemical performance. Bifunctional electrode materials for supercapacitors (SCs) and the hydrogen evolution reaction (HER) have attracted great interest due to their potential applications in green energy storage and conversion. Herein, the bimetallic MnCo LDH is anchored on a hollow sulfur (S)-doped MnCo-MOF-74 surface, forming a poplar flower-like 3D composite which is used for SCs and the HER in alkaline media.

Thyroid-stimulating hormone may participate in insulin resistance by activating toll-like receptor 4 in liver tissues of subclinical hypothyroid rats.

Background: Thyroid-stimulating hormone (TSH) is an independent risk factor of and closely associated with metabolic disorders. In the present study, we explored the potential mechanism and adverse effects of TSH on insulin resistance in the liver of subclinical hypothyroidism models in vivo.

Methods: The mean glucose infusion rate (GIR), free fatty acids (FFAs), the homeostatic model assessment for insulin resistance (HOMA-IR), fasting plasma insulin (FINS), the TLR4 signal pathway and its intracellular negative regulator-toll-interacting protein (Tollip), and the modulators of insulin signaling were evaluated.

Higher Food Yields and Lower Greenhouse Gas Emissions from Aquaculture Ponds with High-Stalk Rice Planted.

Aquaculture ponds are an important artificial aquatic system for global food fish production but also are a hot spot of greenhouse gas (GHG) emissions. The GHG mitigation strategy and the underlying mechanism for aquaculture ponds are still poorly understood. In this study, we conducted a 2 year field experiment to determine the effects of planting high-stalk rice (an artificially bred emergent plant for ponds) on GHG emissions from aquaculture ponds.

MIL-101(Cr) molecular cage anchored on 2D TiCT MXene nanosheets as high-performance electrochemical sensing platform for detection of xanthine.

A new electrochemical sensing material based on the MIL-101(Cr) molecular cage anchored on 2D TiCT-MXene nanosheets was prepared by using the in situ growth molecular engineering strategy. The sensing material was characterized by using different methods such as SEM, XRD, and XPS. The electrochemical sensing performance of MIL-101(Cr)/TiCT-MXene was studied by DPV, CV, EIS, and other techniques.

Development zone policy and urban carbon emissions: empirical evidence from the construction of national high-tech industrial development zones in China.

As a key strategy to promote system reform, improve the investment environment, and encourage industrial agglomeration, the national high-tech industrial development zone (NHTDZ) policy in China can not only reduce energy consumption through the scale effect but also improve energy efficiency by modernizing industrial structure and fostering technological innovation, thereby alleviating environmental pollution. Existing studies, however, focus solely on the effects of NHTDZ policy on social and economic development, ignoring their impact on the ecological environment, especially carbon (CO) emissions that contribute to global warming. Thus, this article analyzes a panel data of 285 prefecture-level cities and above in China from 2003 to 2019 to assess the influence of NHTDZ policy on CO emissions, treating the NHTDZ construction since 1988 as a quasi-natural experiment.

In vitro Anti-malignant Property of PCMT1 Silencing and Identification of the SNHG16/miR-195/PCMT1 Regulatory Axis in Breast Cancer Cells.

Background: Protein L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is a highly conserved protein repair enzyme that participates in regulating the progression of human cancers. We therefore studied the function and the related mechanisms of PCMT1 in breast cancer cells.

Methods: Expression profile and prognostic analysis of PCMT1 in breast cancer patients were analyzed using online databases.

A sensing platform based on Cu-MOF encapsulated Dawson-type polyoxometalate crystal material for electrochemical detection of xanthine.

A promising sensing platform based on polyoxometalate-based metal-organic framework (POMOF) was established for sensitive electrochemical detection of xanthine (XA). In the unique structure of POMOF, the Dawson polyoxoanions PW were encapsulated into 3D open copper-mixed ligand nanotube framework Cu-MOF, in which the cavity of the metal-organic framework provides a specific shelter to prevent the aggregation and loss of polyoxometalate in electrocatalytic reactions; meanwhile, unsaturated Cu(II) active sites of Cu-MOF can also serve as electrocatalytic active center. The POMOF-based sensor (CuMOFPW/XC-72R) was fabricated by using acetylene black (XC-72R) as a support material to enhance the conductivity of POMOF.

Eimeria spp. (Eimeriidae) in the migratory whooper swan (Cygnus cygnus) Linnaeus, 1758 (Anatidae) from Sanmenxia Swan Lake National Urban Wetland Park in the middle reaches of the Yellow River in China.

This study i dentifies four Eimeria spp. recorded from fecal samples of migratory whooper swans (Cygnus cygnus) in Sanmenxia Swan Lake National Urban Wetland Park in Sanmenxia city in the middle reaches of the Yellow River, China. Eimeria hermani, Eimeria nocens, Eimeria stigmosa, and Eimeria magnalabia were compatible in all characteristic features with their respective original descriptions.

The effects of hsa_circ_0000517/miR-326 axis on the progression of breast cancer cells and the prediction of miR-326 downstream targets in breast cancer.

It has been proposed that circular RNAs (circRNAs) play crucial roles in the initiation and progression of various cancers including breast cancer. Our study aimed to determine the function and regulatory mechanism of hsa_circ_0000517 in breast cancer. qRT-PCR was applied to determine hsa_circ_0000517 expression in breast cancer cells.

Effect of phosphorus and potassium addition on greenhouse gas emissions and nutrient utilization of a rice-fish co-culture system.

Greenhouse gas (GHG) emissions from aquaculture have gained widespread attention. However, the effect of phosphorus (P) and potassium (K) on GHG emissions from aquaculture systems has rarely been studied. In this study, we conducted a laboratory-scale experiment to investigate the effect of P and K addition on CH and NO emissions and nutrient use efficiency in a rice-fish co-culture system.

ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.

The role of ROR1-AS1 in non-small-cell lung cancer (NSCLC) remains unclear. Therefore, we aimed to investigate the functional role of ROR1-AS1 in NSCLC and to explore the underlying mechanisms. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was performed to detect cell proliferation.

Bimetallic FeNi-MIL-88-derived NiFeO@Ni-Mn LDH composite electrode material for a high performance asymmetric supercapacitor.

A simple continuous hydrothermal method was used to synthesize a NiFeO@Ni-Mn LDH/NF composite. The layered structure provides a large void to transfer the electron effectively, and the composite materials exhibit remarkable electrochemical performance including excellent specific capacitance (1265 F g at 1 A g) and remarkable cycling stability (the specific capacitance remains at 80.9% after 5000 cycles).

AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway.

Increasing studies have well-documented the involvement of numerous lncRNAs in regulating the malignant phenotypes of various tumors including non-small cell lung cancer (NSCLC) cells. However, up to date, the effects and mechanism of lncRNA amine oxidase, copper containing 4, pseudogene (AOC4P) in NSCLC progression remain undefined. AOC4P expression in NSCLC cells was detected by qRT-PCR.

A novel dual-tasking hollow cube NiFeO-NiCo-LDH@rGO hierarchical material for high preformance supercapacitor and glucose sensor.

Binary transition metal oxides as electroactive materials have continuously aroused grumous attention due to their high theoretical specific capacitance, high valtage window, and multiple oxidation states. However, the tiny specific surface area, poor conductivity and unsatisfactory cycle stability limit their practical application. Hence, a synthetic strategy is designed to fabricate a dual-tasking hollow cube nickel ferrite (NiFeO) - based composite (NiFeO-NiCo-LDH@rGO) with hierarchical structure.