Effects of walking on body composition in perimenopausal and postmenopausal women: a systematic review and meta-analysis.

Objective: The aim of the study was to conduct a systematic review and meta-analysis of randomized controlled trials that examined the effect of walking on body weight, body mass index (BMI), and body fat percentage in perimenopausal and postmenopausal women.

Methods: Two authors identified randomized controlled trials of interventions at least 4 weeks in duration that included at least one group with walking as the only treatment and a no-exercise control group. Participants were inactive at baseline.

Intragenic microdeletion of RUNX2 is a novel mechanism for cleidocranial dysplasia.

Cleidocranial dysplasia (CCD; MIM 119600) is a rare autosomal dominant disorder characterized by facial, dental, and skeletal malformations. To date, rearrangement and mutations involving RUNX2, which encodes a transcription factor required for osteoblast differentiation on 6p21, has been the only known molecular etiology for CCD. However, only 70% patients were found to have point mutations, 13% large/contiguous deletion but the rest of 17% remains unknown.

Ethyl 1-[(2-chloro-1,3-thia-zol-5-yl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate.

In the title compound, C(10)H(11)ClN(4)O(2)S, the triazole ring carries methyl and ethoxy-carbonyl groups and is bound via a methyl-ene bridge to a chloro-thia-zole unit. There is also evidence for significant electron delocalization in the triazolyl system. Intra- and inter-molecular C-H⋯O hydrogen bonds together with strong π-π stacking inter-actions [centroid-centroid distance 3.

Ethyl 1-(6-chloro-3-pyridylmeth-yl)-5-ethoxy-methyl-eneamino-1H-1,2,3-triazole-4-carboxyl-ate.

In the title compound, C(14)H(16)ClN(5)O(3), there is evidence for significant electron delocalization in the triazolyl system. Intra-molecular C-H⋯O and inter-molecular C-H⋯O and C-H⋯N hydrogen bonds stabilize the structure.

Ethyl 1-(6-chloro-3-pyridylmeth-yl)-5-methyl-1H-1,2,3-triazole-4-carboxyl-ate.

In the title compound, C(12)H(13)ClN(4)O(2), the triazole ring carries methyl and ethoxy-carbonyl groups, and is bound via a methyl-ene bridge to a chloro-pyridine unit. There is evidence for significant electron delocalization in the triazolyl system. Intra-molecular C-H⋯O and inter-molecular C-H⋯N hydrogen bonds stabilize the structure.