Publications by authors named "Feng-lan Song"
Objective: To establish the quality standard for Qiangnaosu capsule.
Methods: TLC was used for the qualitative identification of Saposhnikoviae Radix, Chuanxiong Rhizoma, Chrysanthemum Flos, Fructus Viticis. HPLC was used to determine the content of ferulic acid.
Interferon-alpha2b (IFN α-2b) microspheres were prepared at various concentrations (5%, 10%, 15%, 20% and 25%) and viscosities (0.39, 0.6, 0.
View Article and Find Full Text PDFBy a double emulsion solvent evaporation method, interferon-alpha (IFN-alpha) microspheres were prepared with poly(lactide-co-glycolide) (PLGA) and their characteristics, such as morphology, drug loading, encapsulation efficiency, in vitro release and degradation were evaluated. The IFN-alpha microspheres were prepared by different viscosities from 0.17-1.
View Article and Find Full Text PDFPreparation and characteristics of erythromycin microspheres for lung targeting.
Drug Dev Ind Pharm
June 2009
Background: If erythromycin is micronized into microspheres with suitable particle size, it can improve pulmonary drug concentration to maximize its effectiveness and minimize the adverse side effects.
Aim: In this study, erythromycin gelatin microspheres (EM-GMS) were prepared and some characteristics of EM-GMS were investigated. The drug-targeting index (DTI) of EM-GMS was evaluated to predict their potential as a targeted delivery system.
Article Synopsis
- The study aimed to investigate the pharmacokinetic-pharmacodynamic properties of IFN-alpha2b-loaded PLGA microspheres in rhesus monkeys, comparing it with commercial IFN-alpha2b lyophilized powder.
- Biodegradable PLGA microspheres were created using a double emulsion method, and their particle size and in vitro release were analyzed, showing significant differences in effectiveness between the two formulations after administration.
- Results indicated that the PLGA microspheres (specifically the one with an inherent viscosity of 0.89 dL/g) significantly prolonged the drug's presence in the plasma and its biological effects in the monkeys.