[Drugs and the mechanism for reversing the tolerance of flurazepan in rats].

Objective: Benzodiazepines (BDZ) have many effects on various kinds of epilepsies, but long-term treatment with BDZ often leads to drug tolerance. This study aimed to seek drugs which can reverse the tolerance of flurazepam (FZP), and to explore the role of neuropeptide Y (NPY) in the reversal effect.

Methods: A rat model of anticonvulsant tolerance to FZP was prepared.