Publications by authors named "Feng-Yan Han"
Role of HPV status and PD-L1 expression in prognosis of laryngeal squamous cell carcinoma.
Int J Clin Exp Pathol
January 2021
Purpose: Human papillomavirus (HPV) infection has been recognized as a cause of head and neck squamous cell carcinomas (HNSCC). Laryngeal squamous cell carcinoma (LSCC) is one of the most common pathologic types of HNSCC. Clinical trials show that there are differences in response to immunotherapy according to HPV status.
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- High-risk HPV infection is associated with the onset of oropharyngeal squamous cell carcinoma (OPSCC), a type of head and neck cancer that has seen a rising incidence in recent years.
- A study analyzed 49 OPSCC cases to evaluate the presence of HPV types 16 and 18, alongside the expression levels of proteins P53, P21, and Cdc2, utilizing various diagnostic methodologies to gather clinical data.
- The findings indicated that 28.6% of OPSCC cases were HPV-DNA positive, with a notably higher prevalence in non-smokers, and revealed no significant correlations between HPV infection and patient demographics, tumor characteristics, or protein expression levels.
The aim of this study was to explore the correlation between HPV infection, p53, p16, epidermal growth factor receptor (EGFR), p34 protein expression and prognosis in patients with adenoid cystic carcinoma of salivary gland. Totally 78 cases of adenoid cystic carcinoma of salivary gland specimens were selected from January 1, 2004 to December 31, 2013 in Tangshan Union Hospital. PCR-reverse dot blot hybridization was used to detect infection of human papilloma virus (HPV), and SP immunohistochemical method was adopted to detect the expression of p53, p16, EGFR and p34 protein in the carcinoma tissues.
View Article and Find Full Text PDF[Polymorphous low-grade adenocarcinoma of ear: one case report].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
February 2011