Preliminary proteomic analysis of human tears in lacrimal adenoid cystic carcinoma and pleomorphic adenoma.

Aim: To detect proteomic differences in tears between adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA).

Methods: Tear samples were collected from 4 patients with ACC, 5 with PA, and 4 control cases. Label-free analysis and parallel reaction monitoring (PRM) were used to screen and validate the tear proteome.

Lacrimal sac lymphoma: a case series and literature review.

Aim: To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region.

Methods: Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed.

Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells.

Aim: To detect how BRCA-associated protein 1 (BAP1) regulates cell migration in uveal melanoma (UM) cells.

Methods: Wound healing and transwell assays were performed to detect UM cell migration abilities. Protein chip, immunoprecipitations and surface plasmon resonance analyses were applied to identify BAP1 protein partners.

[Present status on studies of differentiation into retinal neurons and pigmented cell from induced pluripotent stem cells].

Somatic cells could be induced into pluripotent stem (iPS) cells through transferring special genes (Oct4, Sox2, c-myc and Klf4). This has brought a revolutionary change in stem cell study and application. The generation of iPS cells has great potential and enormous significance as it can resolve some insurmountable problems in stem cells research, such as ethical dilemma, immune rejection, etc.

[Changes of neuroglia cells in human glaucoma and animal model of experimental glaucoma].

Glaucoma is one of the major ocular diseases that lead to blindness. It is characterized by optic disk cupping and visual field loss. Glaucoma is a multifactorial group of diseases with many different causes but one common endpoint, progressive loss of retinal ganglion cells.