Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats.

Betatrophin [also known as lipasin, angiopoietin‑like 8 (ANGPTL8), refeeding induced in fat and liver (RIFL), or hepatocellular carcinoma‑associated gene TD26], a 22‑kDa protein in the angiopoietin‑like family, is a liver‑derived hormone that promotes pancreatic β‑cell proliferation and lipid metabolism. The aim of the present study was to investigate the effect of recombinant betatrophin on β‑cell regeneration in a neonatal streptozotocin (STZ)‑induced diabetic rat model. One‑day‑old Wistar rats were injected with STZ (100 mg/kg), followed by intraperitoneal administration of betatrophin to the STZ‑injected rats for 6 days.

[Expression and significance of metallothionein in the placenta of women with low level lead exposure during pregnancy].

Objective: To investigate the significance of metallothionein (MT) expression in the placenta of women exposed to low level lead during pregnancy.

Methods: Sixty-seven pregnant women with blood lead level ranging from 1.5 micromol/L to 4.

[Effects of lead exposure to rat placenta and pups during different gestation periods].

Objective: To investigate the effects of lead exposure to rat placenta and pups during different gestation periods.

Methods: All 108 Wistar rats (72 females, 36 males) were randomly divided into four groups. All rats were orally fed with 0.

[Effects of intervening measures on postpartum depression].

Objective: To study the related factors of postpartum depression (PPD) and the effects of intervening measures to PPD incidence.

Methods: 1 597 pregnant women selected from our antenatal care clinic were investigated by using the hospital anxiety and depression questionnaire (HAD) during pregnancy and the Edinburgh postpartum depression scale (EPDS) after childbirth. All the enrolled women were randomly divided into control group and intervening group by the proportion of 1 to 2.