Publications by authors named "Feng-Meng Teng"

Article Synopsis
  • Abelmoschus manihot (HK) is traditionally used to treat kidney diseases and may have protective effects against chronic kidney disease (CKD) induced by cisplatin (CDDP), a chemotherapy drug with nephrotoxic side effects.
  • This study investigated HK's protective mechanisms against CKD in rats using metabolomics and network pharmacology, which analyzed serum, urine, and kidney samples to identify biomarkers and metabolic pathways affected by HK.
  • Results showed that HK mitigated CDDP-induced metabolic disruptions, particularly linked to tryptophan metabolism, and highlighted specific compounds and genes in HK that contribute to its nephroprotective effects.
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Objective: To observe the intervention effect of Jujing Gouju Granules (JGG) on teratozoospermia (TZ) in rats and explore its action mechanism.

Methods: Thirty-two male SD rats were randomly divided into four groups of an equal number: normal control, TZ model control, high-dose JGG and low-dose JGG. The TZ model was established in the latter three groups of rats by intragastric administration of methyl methanesulfonate at 4 mg/100 g body weight/day for 7 consecutive days.

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The aim of this study is to explore the expression and significance of urokinase-type plasminogen activator (u-PA) and vascular endothelial growth factor (VEGF) in gastric cancer, providing a novel insight for the diagnosis and treatment of gastric cancer. The gastric cancer specimens, which were excised from 87 patients and confirmed during July, 2012-July, 2014, were selected as observation group, and the normal tissue next to the tumor (more than 5 cm from the edge of the tumor) from 45 patients were randomly selected as control. u-PA and VEGF were detected by immunohistochemistry for the analysis of the correlation of u-PA and VEGF in two groups.

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Background: Hepatocellular carcinoma (HCC) still is a big burden for China. In recent years, the third-generation platinum compounds have been proposed as potential active agents for HCC. However, more experimental and clinical data are warranted to support the proposal.

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