Publications by authors named "Feng-Lin Tang"
Article Synopsis
- Epilepsy is linked to an imbalance in brain excitation and inhibition, with mutations in the MBD5 gene contributing to the condition.
- Research shows that MBD5 is mainly found in specific cells of the mouse hippocampus and its levels increase in epilepsy models.
- Overexpressing MBD5 worsens seizures by affecting the expression of certain NMDAR subunits, while increasing STAT1 levels or using the drug memantine can alleviate seizure symptoms, pointing to a potential new treatment pathway.
