[Distribution of memory B cell subsets in peripheral blood of children with frequently relapsing nephrotic syndrome].

Objectives: To investigate the change in the distribution of memory B cell subsets in children with frequently relapsing nephrotic syndrome (FRNS) during the course of the disease.

Methods: A total of 35 children with primary nephrotic syndrome (PNS) who attended the Department of Pediatrics of the Affiliated Hospital of Xuzhou Medical University from October 2020 to October 2021 were enrolled as subjects in this prospective study. According to the response to glucocorticoid (GC) therapy and frequency of recurrence, the children were divided into two groups: FRNS (=20) and non-FRNS (NFRNS; =15).

Establishment of relapse risk model and multivariate logistic regression analysis on risk factors of relapse in children with primary nephrotic syndrome.

This study aimed to investigate relapse risk factors in children with primary nephrotic syndrome (PNS) for prevention and early intervention via logistic regression. One hundred thirty-seven children with PNS were enrolled in this study. Clinical variables were analyzed by single-factor and multiple regression analysis to establish the regression equation.

[Clinical effect and mechanism of total glucosides of paeony in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis: a prospective randomized controlled study].

Objective: To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (=34) and a routine treatment group (=30) using a random number table. Thirty healthy children who underwent physical examination were enrolled as the healthy control group.

Histone deacetylase-2 expression and activity in children with nephrotic syndrome with different glucocorticoid response.

Background: Glucocorticosteroid (GC) is one of the most effective drugs available for the treatment of primary nephrotic syndrome (PNS) in children. However, some patients show little or no response to GC. The purpose of our research was to observe and describe the different levels of histone deacetylase-2 (HDAC2) expression in peripheral blood lymphocytes in children with PNS compared with various responses to the GC treatment, with the primary aim to assess the correlation between HDAC2 and GC resistance in PNS children.

[Bone mesenchymal stem cell transplantation repairs glomerular podocytes in rats with puromycin aminonucleoside-induced nephrosis].

Objective: To investigate the effect of bone mesenchymal stem cell (BMSC) transplantation on repair of glomerular podocytes and on the Nephrin expression in rats with puromycin aminonucleoside (PAN) -induced nephrosis.

Methods: Forty-five Sprague-Dawley rats were randomly divided into three groups (n=15 each): a nephrosis model group that received a single intraperitoneal injection of PAN (0.15 mg/g); a BMSC transplantation group that received a single intraperitoneal injection of PAN (0.

[Glucocorticoid administration in steroid sensitive nephritic syndrome: a meta-analysis].

Objective: To evaluate the benefits and toxicities of different corticosteroid regimes in preventing relapse in children with steroid sensitive nephrotic syndrome (SSNS).

Methods: MEDLINE (Jan. 1963-Mar.

[Clinicopathologic characteristics of 1,316 children with renal disease].

Objective: To investigate the clinicopathologic characteristics of childhood renal diseases.

Methods: A retrospective analysis of 1316 renal biopsies performed over the past 20 years was performed.

Results: Of the 1316 patients, 383 (29.