Dynamics trajectory of patient-reported quality of life and its associated risk factors among hepatocellular carcinoma patients receiving immune checkpoint inhibitors: a prospective cohort study.

Objective: We aimed to characterize quality of life (QOL) trajectories among patients with intermediate and advanced hepatocellular carcinoma patients treated with immunotherapy.

Methods: Barcelona Clinic Liver Cancer (BCLC) stage B-C HCC patients receiving immunotherapy at Guangxi Medical University Cancer Hospital were included. Trajectories of QOL, assessed using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire, were identified through iterative estimations of group-based trajectory models.

Associations of tumor-related psychiatric symptoms and healthy behaviors with dynamic quality of life after hepatocellular carcinoma hepatectomy.

Objective: To assess the independent and combined associations of tumor-related psychiatric symptoms (TRPS) with dynamic health-related quality of life (HRQL) in patients with hepatocellular carcinoma (HCC) after hepatectomy and to identify related patterns of health behaviors.

Methods: This prospective study included patients with HCC who underwent hepatectomy between September 2021 and May 2022. Independent and combined associations between TRPS and HRQL were identified by generalized linear model and weighted quantile sum model, respectively.

Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial.

Introduction: As the main manifestation of gallstone disease, biliary colic (BC) is an episodic attack that brings patients severe pain in the right upper abdominal quadrant. Although acupuncture has been documented with significance to lead to pain relief, the immediate analgesia of acupuncture for BC still needs to be verified, and the underlying mechanism has yet to be covered. Therefore, this trial aims first to verify the immediate pain-alleviation characteristic of acupuncture for BC, then to explore its influence on the peripheral sensitised acupoint and central brain activity.

Cross-Sectional Study of the Effects of Job Burnout on Immune Function in 105 Female Oncology Nurses at a Tertiary Oncology Hospital.

BACKGROUND Nurses who work in hospitals experience a high level of burnout and the relationship between immune variables and burnout syndrome has yet to be elucidated. The aim of the present study was to investigate the effects of job burnout on immune function in female oncology nurses in a tertiary oncology hospital in Guangxi, China. The aspects of the human immune system evaluated were humoral and cellular immunity and complement components 3 (C3) and 4 (C4).

The Combination of Charge and Energy Transfer Processes in MOFs for Efficient Photocatalytic Oxidative Coupling of Amines.

Combining electron and energy transfer processes is very significant for efficient photocatalytic oxidation of organic molecules. The first synthesized MOF, Co(L)(2,6-NDC)·guest (, L = bis(-pyridyl) tetrachloroperylene peryleneimide, 2,6-NDC = 2,6-naphthalenedicarboxylic acid, FJI = Fujian Institute), shows a 2-fold interpenetrated net, in which the 2,6-NDC ligand connects typical Co(COO) paddle wheel clusters to form square lattices pillared by new PDI-type ligand L. as a heterogeneous and recyclable photocatalyst is applied for photo-oxidation of benzylamine and its derivatives with an excellent yield of 100%, which is much higher than that (59%) of the equivalent L ligand as a homogeneous photocatalyst under the same reaction conditions.

Association between LKB1 expression and prognosis of patients with solid tumours: an updated systematic review and meta-analysis.

Objectives: Liver kinase B1 (LKB1) is considered a tumour suppressor that can control cell growth and metabolism. Whether LKB1 expression levels are related to clinicopathology and prognosis is controversial. This review aimed to quantitatively examine the latest evidence on this question.

Optimizing H, D, and CH Sorption Properties by Tuning the Pore Apertures in Metal-Organic Frameworks.

By adjustment of the arm lengths of two triphenylamine-based ligands, two nearly isostructural metal-organic frameworks (MOFs), namely, the reported nanoporous FIR-29 (FIR = Fujian Institute of Research) and the new microporous FJI-Y9 (FJI = Fujian Institute), are obtained, and all exhibit honeycomb lattices of hexagonal channels with Ca-COO chains connected by tris[(4-carboxyl)phenylduryl]amine (HTCPA) ligands and 4,4',4''-nitrilotribenzoic acid (HNTB) ligands, respectively. Although the Brunauer-Emmett-Teller (BET) surface area (1117 m g) and pore size (8.5 Å) of FJI-Y9 are much lower than those (BET surface area of 2061 m g and pore size of 16 Å) of the reported FIR-29 because of the shorter arm lengths of HNTB, the activated FJI-Y9-ht shows high H (202.

Bisorption of chromium(VI) from aqueous solutions by Kuntze.

The potential to remove Cr(VI) from aqueous solutions through biosorption using dried Kuntze was investigated with respect to initial pH, amount of biosorbent, initial Cr(VI) concentrations and temperature. Cr(VI) removal efficiency was influenced significantly by the variation of pH, and the optimum pH was about 2.0.

Salting-out homogeneous liquid-liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC-MS.

A convenient, robust, economical and selective sample preparation method for the quantitative determination of entecavir in human plasma by LC-MS was developed and validated. Entecavir and the internal standard of acyclovir were extracted from 500 μL of human plasma by a salting-out homogeneous liquid-liquid extraction approach (SHLLE) with acetonitrile as the organic extractant and magnesium sulfate as the salting-out reagent. They were analyzed on a Hanbon® Lichrospher RP C18 HPLC column (150 mm×2.

Suppression of Akt1 expression by small interference RNA inhibits SGC7901 cell growth in vitro and in vivo.

The Akt/PKB kinase family, including Akt1, 2 and 3, plays critical roles in regulating cell growth, proliferation, survival, metabolic and many other cellular activities. Recent evidence indicates that PKB/Akt is frequently constitutively active in many types of human cancer including gastric cancer. In the present study, we applied immunohistochemistry to tissue microarray to detect the expression of Akt1, followed by Akt1 small interference RNA (siRNA) to examine knock down of the Akt1 gene on the growth inhibition of human gastric cancer SGC7901 cells.

[The relationship of MMP-9, VEGF and PCNA expressions and their clinical significance in gastric adenocarcinoma].

Objective: To investigate abnormal protein expression of matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in human gastric adenocarcinoma, and further reveal the clinical significance.

Method: The MMP-9, VEGF and PCNA proteins expression was determined by immunohistochemistry staining in 45 gastric adenocarcinoma tissues, 45 adjacent specimens and 10 normal gastric mucosa tissues via tissue arrays accordingly. The relationship of these protein expression with differentiation degree, development and progression of gastric adenocarcinoma were also analyzed.