Publications by authors named "Feng Yunlin"
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. Here we show a simple, real-time, interpretable AKI prediction model for general hospitalized patients developed from a large tertiary hospital in China, which has been validated across five independent, geographically distinct, different tiered hospitals.
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- - The study investigates the effectiveness and safety of various anticoagulation methods used during plasma exchange (PE), noting that current methods can lead to clotting issues that waste nursing resources.
- - A systematic review included 7 studies involving over 1,600 patients, finding that unfractionated heparin (UFH) was better than saline for preventing clotting but showed similar results to low-molecular-weight heparin (LMWH) and regional citrate anticoagulation (RCA).
- - The findings suggest that while current anticoagulation methods are generally effective, there's a risk of longer post-treatment aPTT (a clotting test) and lower platelet counts with UFH; however, more research is needed for
Article Synopsis
- - The study reviews the effectiveness and safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) in treating anemia in chronic kidney disease (CKD) patients, focusing particularly on their safety profiles.
- - A comprehensive analysis of 47 studies, including 55 randomized controlled trials, found that all six commercially available HIF-PHIs can effectively increase hemoglobin levels compared to placebo, with no significant safety risks compared to traditional treatments like erythropoiesis stimulating agents (ESAs).
- - Despite the positive findings, the study highlights the need for more long-term research and continued monitoring to ensure ongoing safety and efficacy for HIF-PHIs in CKD
To clarify the prevalence of adverse renal outcomes following targeted therapies in renal cell carcinoma (RCC). A systematic search was performed in MEDLINE, EMBASE, and Cochrane Central Library. Studies that had reported adverse renal outcomes following targeted therapies in RCC were eligible.
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- The study aimed to explore how systemic immune-inflammation indices can predict vascular access failure in patients undergoing hemodialysis (HD).
- It analyzed data from 2,690 patients who received HD vascular access surgeries, finding that certain indices, particularly the SII, were strongly associated with access failure.
- A prediction model using the SII was created to forecast HD access survival rates, showing promising results that could be enhanced with larger, multi-center studies.
Background: [F] AlF-NOTA-FAPI-04 is a novel positron emission tomography (PET) ligand, which specifically targets fibroblast activation protein (FAP) expression as a FAP inhibitor (FAPI). We analysed the diagnostic value of [F] AlF-NOTA-FAPI-04 PET/CT for the non-invasive assessment of kidney interstitial inflammation and fibrosis in different renal pathologies.
Methods: Twenty-six patients (14 males and 12 females; mean age, 50.
Some pregnant women have to experience non-obstetric surgery during pregnancy under general anesthesia. Our previous studies showed that maternal exposure to sevoflurane, isoflurane, propofol, and ketamine causes cognitive deficits in offspring. Histone acetylation has been implicated in synaptic plasticity.
View Article and Find Full Text PDFThe objective was to provide a comprehensive summary of existing evidence on the efficacy and safety of hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) for the treatment of anemia in chronic kidney disease (CKD). A systematic search was conducted in the Medline, Embase, and Cochrane databases. Only meta-analyses that evaluated the efficacy and safety of HIF-PHI treatment for anemia in CKD were included.
View Article and Find Full Text PDFBackground: The prevention and treatment of malnutrition holds remarkable implications in the overall management of dialysis patients. However, there remains a dearth of comprehensive evaluations regarding the impact of oral nutrition supplement (ONS) on all pertinent dimensions of malnutrition in the dialysis population.
Methods: A systematic search was conducted in MEDLINE, EMBASE, and Cochrane Central Library.
Objective: A novel albumin-to-alkaline phosphatase ratio (AAPR) is associated with the prognosis of several cancers. In the present study, we evaluate the prognostic significance of perioperative AAPR in urological cancers.
Method: Relevant studies were searched comprehensively from CNKI, PubMed, Embase and Web of Science up to March 2023.
Background: Primary membranous nephropathy (PMN) has a heterogeneous natural course. Immunosuppressive therapy is recommended for PMN patients at moderate or high risk of renal function deterioration. Prediction models for the treatment failure of PMN have rarely been reported.
View Article and Find Full Text PDFHuaganjian decoction (HGJD) has been widely used clinically to treat liver injuries and gastritis. However, the quality evaluation system for HGJD is not perfect. In this study, paeoniflorin, hesperidin, geniposide, naringin, and quercetin were employed as quality markers.
View Article and Find Full Text PDFBackground: There is still a lack of high-level evidence on the effects of problem-based learning (PBL) in general medical and nursing education.
Aims: We aimed to summarize current evidence on the effects of PBL in delivering medical and nursing education from randomized controlled trials (RCTs).
Methods: A systematic search was performed in MEDLINE, EMBASE, Cochrane Central Library, and CINAHL Complete.
Importance: Despite the expansion of published prediction models for acute kidney injury (AKI), there is little evidence of uptake of these models beyond their local derivation nor data on their association with patient outcomes.
Objective: To systematically review published AKI prediction models across all clinical subsettings.
Data Sources: MEDLINE via PubMed (January 1946 to April 2021) and Embase (January 1947 to April 2021) were searched using medical subject headings and text words related to AKI and prediction models.
We aimed to investigate the mechanisms of Brahma related gene 1 (BRG1) in promoting vascular calcification in chronic kidney disease (CKD). The expression of BRG1 was examined in high phosphorus stimulated rat aortic smooth muscle cells (RASMCs) and calcified artery tissues from rat models and hemodialysis patients. Autophagosome formation was measured in high phosphorus stimulated RASMCs with and without BRG1 knock-down.
View Article and Find Full Text PDFBackground: Podocyte infolding glomerulopathy (PIG) is a peculiar and very rare manifestation in renal pathology. Its underlying pathogenesis mechanism and clinical characteristics remain unclear due to sparse reports.
Objective: To further elucidate the clinical profile of PIG by carefully reporting our four cases and a comprehensive review of cases in the literature.
Traditional medicine, 'LuRu', is a commonly used Tibetan medicine for clearing away heat and detoxifying. Dried products of and are often used as 'LuRu' in the market. This study aims to compare the chemical constituents of and using GC-MS and UPLC-TOF-MS, and confirm which plant species is more suitable to be used as 'LuRu'.
View Article and Find Full Text PDFBackground: There is conflicting data on the effect of vitamin K supplementation against vascular calcification in chronic kidney disease (CKD). We aimed to summarize current evidence from randomized controlled trials (RCTs) to determine whether vitamin K supplementation in CKD could attenuate vascular calcification.
Methods: A systematic search was performed in MEDLINE, EMBASE, and Cochrane Central Library.
Background: Several statistical models for predicting prognosis of primary membranous nephropathy (PMN) have been proposed, most of which have not been as widely accepted in clinical practice.
Methods: A systematic search was performed in MEDLINE and EMBASE. English studies that developed any prediction models including two or more than two predictive variables were eligible for inclusion.
Background: Acute kidney injury (AKI) is independently associated with morbidity and mortality in a wide range of surgical settings. Nowadays, with the increasing use of electronic health records (EHR), advances in patient information retrieval, and cost reduction in clinical informatics, artificial intelligence is increasingly being used to improve early recognition and management for perioperative AKI. However, there is no quantitative synthesis of the performance of these methods.
View Article and Find Full Text PDFBackground: To develop a risk prediction model for the occurrence of severe acute kidney injury (AKI) in intensive care unit (ICU) patients receiving fluid resuscitation.
Methods: We conducted a secondary analysis of the Crystalloid vs. Hydroxyethyl Starch Trial (CHEST) trial, a blinded randomized controlled trial that enrolled ICU patients who received intravenous fluid resuscitation.
Rationale: Severe heart failure in chronic hemodialysis (HD) patients is a great treatment challenge. Here we reported a chronic HD patient with the lowest ejection fraction reported so far and hypotension who well tolerated and benefited from angiotensin-receptor neprilysin inhibitor (ARNI) treatment.
Patient Concerns: This case was a 67 year old lady with decompensated heart failure and hypotension who was on regular HD.