Association Between Patient Portal Engagement and Weight Loss Outcomes in Patients After Bariatric Surgery: Longitudinal Observational Study Using Electronic Health Records.

Background: Bariatric surgery is an effective intervention for obesity, but comprehensive postoperative self-management is essential for optimal outcomes. While patient portals are generally seen as beneficial in engaging patients in health management, the link between their use and post-bariatric surgery weight loss remains unclear.

Objective: This study aimed to investigate the association between patient portal engagement and postoperative BMI reduction among patients after bariatric surgery.

Pore-Scale Gas Storage Mechanisms, Characteristics, and Influencing Factors in Water-Bearing Shale: Insights from Molecular Dynamics Simulations.

In order to explore the microscopic storage mechanism of shale gas in water-bearing pores and its influencing factors, this article first establishes a molecular dynamics model for methane in different types of adsorbents using molecular dynamics simulation and the grand canonical ensemble Monte Carlo methods. These adsorbents include graphene, organic matter (kerogen), brittle minerals (quartz and albite), carbonate minerals (calcite), and clay minerals (illite, kaolinite, and montmorillonite). Then, by analyzing the molecular storage model and density distribution curves of methane in pores, the storage mechanisms of shale gas are analyzed and elucidated.

Mitochondrial 'Birth-Death' coordinator: An intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration.

Currently, mitochondrial dysfunction caused by oxidative stress is a growing concern in degenerative diseases, notably intervertebral disc degeneration (IVDD). Dysregulation of the balance of mitochondrial quality control (MQC) has been considered the key contributor, while it's still challenging to effectively harmonize different MQC components in a simple and biologically safe way. Hydrogen gas (H) is a promising mitochondrial therapeutic molecule due to its bio-reductivity and diffusibility across cellular membranes, yet its relationship with MQC regulation remains unknown.

Developing a Generative AI-Powered Chatbot for Analyzing MAUDE Database.

This paper presents a chatbot that simplifies accessing and understanding the open-access records of adverse events related to medical devices in the MAUDE database. The chatbot is powered by generative AI technology, enabling count and search queries. The chatbot uses the openFDA API and GPT-4 model to interpret users' natural language queries, generate appropriate API calls, and summarize adverse event reports.

A Data Pipeline for Enhancing Quality of MAUDE-Based Studies.

The increasing use of MAUDE reports in patient safety research highlights the importance of understanding the processing and dissemination of open-access MAUDE data. However, the absence of a structured data pipeline undermines the reproducibility and transparency of studies relying on MAUDE data. In response, we conducted a comprehensive analysis of a recent study on endoscopic clips, assessing methodologies and results.

Active Magnesium Boride/Alginate Hydrogels Rejuvenate Senescent Cells.

The clearance of senescent cells may be detrimental to low cell density diseases, such as intervertebral disc degeneration (IVDD), and rejuvenating these cells presents a formidable obstacle. In this study, we investigate a mild-alkalization strategy employing magnesium boride-alginate (MB-ALG) hydrogels to rejuvenate senescent cells associated with age-related diseases. MB-ALG hydrogels proficiently ensnare senescent cells owing to their surface roughness.

Enhancing MAUDE Database Utility by GPT-4 and Cause-Effect Visualization.

The MAUDE database is a valuable public resource for understanding malfunctions and adverse events related to medical devices and health IT. However, its extensive data and complex structure pose challenges. To overcome this, we have developed an automated analytical pipeline using GPT-4, a cutting-edge large language model.

Assessing the Reproducibility of Research Based on the Food and Drug Administration Manufacturer and User Facility Device Experience Data.

Objective: This article aims to assess the reproducibility of Manufacturer and User Facility Device Experience (MAUDE) data-driven studies by analyzing the data queries used in their research processes.

Methods: Studies using MAUDE data were sourced from PubMed by searching for "MAUDE" or "Manufacturer and User Facility Device Experience" in titles or abstracts. We manually chose articles with executable queries.

Accurate Spatio-Temporal Delivery of Nitric Oxide Facilitates the Programmable Repair of Avascular Dense Connective Tissues Injury.

Avascular dense connective tissues (e.g., the annulus fibrosus (AF) rupture, the meniscus tear, and tendons and ligaments injury) repair remains a challenge due to the "biological barrier" that hinders traditional drug permeation and limits self-healing of the injured tissue.

Enhanced Patient Portal Engagement Associated with Improved Weight Loss Outcomes in Post-Bariatric Surgery Patients.

Background: Bariatric surgery is an effective intervention for obesity, but it requires comprehensive postoperative self-management to achieve optimal outcomes. While patient portals are generally seen as beneficial in engaging patients in health management, the link between their use and post-bariatric surgery weight loss remains unclear.

Objective: This study investigated the association between patient portal engagement and postoperative body mass index (BMI) reduction among bariatric surgery patients.

Morphology design and electronic configuration of MoSe anchored on TiO nanospheres for high energy density sodium-ion half/full batteries.

Molybdenum selenide (MoSe) has shown potential sodium storage properties due to its large layer spacing (0.646 nm) and high theoretical capacity and narrow band gap. However, as the anode material of sodium ion batteries (SIBs), the MoSe's performance is not ideal, especially due to the layer agglomeration and stacking caused by volume expansion and low intrinsic conductivity.

Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment.

The pathogenesis of intervertebral disc degeneration (IVDD) is attributed to metabolic dysregulation within the extracellular matrix and heightened apoptosis of nucleus pulposus cells (NPC). Therefore, a potential therapeutic strategy for managing IVDD involves the reestablishment of metabolic equilibrium within the extracellular matrix and the suppression of excessive myeloid cell apoptosis. The microRNA, miR-5590, displays marked differential expression in degenerative nucleus pulposus (NP) tissues and exerts a direct influence on the regulation of DDX5 expression.

Aliovalent doping and structural design of MoSe with fast reaction kinetics for high-stable sodium-ion half/full batteries.

The development of high-quality anode materials is critical for the advancement of sodium-ion batteries (SIBs). MoSe is a candidate anode for SIBs, while its inherent limitations, such as the agglomeration of nanosheets, poor electron conductance and mechanical strain due to volume changes during cycling, which can lead to decreased performance and durability in SIBs. To overcome the challenges, a novel aliovalent doping and structural engineering was taken to prepare reduced graphene oxide (rGO) functionalized and phosphorus-doped MoSe flake (P-MoSe@rGO) via in situ growth technique.

Assessing Intrahospital Care Transition Structures Before and During the COVID-19 Pandemic: Network Analysis Study.

Transitions of care (TOC) is essential for patients with complex medical needs to maintain the continuity of care. The COVID-19 pandemic may result in unexpected pressure on healthcare organizations' routine work and may burden the TOC system. The objective of this study is to assess TOC structures in pre- and intra-COVID-19 and quantify changes in the structures through the lens of network analysis.

Taking pleasure at another's misfortune: the implicit Schadenfreude of disaster spectators.

Implicit Schadenfreude of disaster spectators, with augmentation of implicit self-esteem and higher reward responsiveness as indicators, and the influence of insecurity and masculinity was explored in two studies. Both studies were conducted under conditions without any clearly legitimizing factors. Experimental (priming with disaster video) and control (priming with neutral video) groups were compared using the Implicit Association Test in Study 1, the results of which showed augmentation of implicit self-esteem in the experimental group.