Global, Regional and National Burden of Edentulism and Periodontal Diseases from 1990 to 2021: Analysis of Risk Factors and Prediction of Trends in 2050.

Background/aim: Periodontal diseases and edentulism remain a prevalent and disabling oral health condition worldwide, with significant regional disparities. This study systematically evaluated the burden of periodontal disease and edentulism at global, regional, and national levels from 1990 to 2021, using the Global Burden of Disease (GBD) 2021 framework.

Patients And Methods: We analyzed trends in incidence, prevalence, and years lived with disability (YLD), exploring their associations with the socio-demographic index (SDI) and other risk factors.

An Unexpected Relationship Between Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: A Mendelian Randomization Study.

Background/aim: Head and neck cancer (HNC) is the sixth most common type of cancer worldwide. While it is widely accepted that human papillomavirus (HPV) infection is a crucial risk factor for the development of this type of cancer, there is still a lack of support from large-scale studies. This article addresses this gap by comprehensively analyzing the causal relationship between HPV infection and head and neck cancer using Mendelian randomization methods.

High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT).

Introduction: Microsatellite stable (MSS) colorectal cancer with liver metastases (CLRM) responds poorly to immunotherapy, and various approaches to break immune tolerance have been tried. Radiotherapy in combination with immune checkpoint inhibitors is one of promising therapies, and the choice of radiotherapy and immunotherapy modalities is also a hot issue.

Methods: Here, we report on a Phase I trial treating nine patients with MSS CLRM using a combination of high and low dose radiotherapy and immune checkpoint inhibitors (ICIs).

Exhaled breath is feasible for mild cognitive impairment detection: A diagnostic study with portable micro-gas chromatography.

BackgroundMild cognitive impairment (MCI) is an important prodromal stage of Alzheimer's disease (AD), affecting 69 million individuals worldwide. At present, there is a lack of a community-applicable tool for MCI screening. Exhaled breath volatile organic compounds (VOCs) have been used to distinguish MCI from cognitively normal (CN) individuals only in small sample size studies and the efficacy has not been compared with blood biomarkers.

The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults.

Air pollution and gut microbial abundance (GMA) are both closely related with asthma incidence. This study aims to explore significant interact on the risk of incident asthma in adult exist between GMA and PM exposure based on a prospective cohort of UK Biobank. Polygenic score of GMA was calculated using 19 distinct single nucleotide polymorphisms.

Clinical and omics biomarkers in osteoarthritis diagnosis and treatment.

Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts the quality of life for hundreds of millions, and is a major cause of disability. Despite this, diagnostic and therapeutic options for OA are still limited. With advances in molecular biology, an increasing number of OA biomarkers have been identified, which not only enhances our understanding of OA pathogenesis, but also offers new approaches for OA diagnosis and treatment.

Protective effects of MET channels on aminoglycosides- and cisplatin-induced ototoxicity.

Aminoglycosides and cisplatin drugs are extensively utilized for their high efficacy in treating various conditions in the clinic, however, their ototoxic side effects warrant significant attention. These drugs could penetrate the inner ear via specific channels or transporters, which not only affect the survival of hair cells but also induce the overproduction of reactive oxygen species. Currently, scientific research mainly addresses this issue through the downstream intervention of reactive oxygen species.

Modeling of auditory neuropathy spectrum disorders associated with the variant reveals impaired gap junction function of iPSC-derived glia-like support cells.

Auditory neuropathy spectrum disorder (ANSD) is an auditory dysfunction disorder characterized by impaired speech comprehension. Its etiology is complex and can be broadly categorized into genetic and non-genetic factors. mutation is identified as a causative factor in ANSD.

RNF112, whose transcription is regulated by KLF4, inhibits colorectal cancer growth via promoting ubiquitin-dependent degradation of NAA40.

Background: RING finger protein 112 (RNF112) exerts a key role in human tumors. However, its biological function in colorectal cancer (CRC) has not been discussed. We aimed to explore the function and molecular mechanism of RNF112 in CRC.

Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.

Background: There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming, but these feedstuffs are fibrous in nature. This study investigated the relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs.

Methods: Thirty-six growing barrows (47.

Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study.

Objective: The relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL).

Methods: This cross-sectional study was conducted among a population of outpatients diagnosed with ARHL at four medical centers in different regions of China, from June 2020 to June 2023.

The efficacy analysis of laparoscopic-assisted Soave procedure for Hirschsprung's disease in neonates and infants within 3 months of age.

To evaluate the efficacy of laparoscopic-assisted Soave procedure of Hirschsprung's Disease (HSCR) in neonates and infants within 3 months of age. Patients with HSCR who were admitted to the Department of Fetal and Neonatal Surgery of Hunan Children's Hospital from June 2012 to July 2020 and underwent laparoscopic-assisted Soave procedure were selected. The clinical manifestations, surgical procedures, postoperative fecal contamination, constipation, enterocolitis, and defecation function were analyzed.

miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells.

Introduction: Hypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis. microRNAs (miRNAs) are a class of small non-coding RNAs that exert their functions by inhibiting the expression of their target genes, and miR-210 is the miRNA universally and most conspicuously upregulated by hypoxia in mammalian systems. For its relationship to hypoxia, miR-210 has been studied extensively, yet no consensus exists on the roles and mechanisms of miR-210 in human physiological processes or diseases, and we know little about genuine miR-210 target genes in humans.

[Value of exercise challenge testing in the diagnosis of cough variant asthma in children].

Objectives: To investigate the value of exercise challenge testing (ECT) in the diagnosis of cough variant asthma (CVA) in children.

Methods: A prospective study was conducted on 78 children with chronic cough who were admitted between January 2023 and January 2024. ECT was performed, and clinical data were collected.

Associations of osteoarthritis with risk of future fracture events: prospective study in UK Biobank.

Background: Researchers have long been interested in the potential relationship between osteoarthritis (OA), falls, and fractures; however, the evidence supporting this relationship has been conflicting. This study aimed to investigate the association between osteoarthritis and future fracture events.

Materials And Methods: This study was designed as a prospective cohort study.

Influences of Fermented Corn Straw Fiber on Performance and Nutrient Utilization in Different Breeds of Finishing Pigs.

This study aimed to explore the effects of dietary fiber level and breed on the growth performance, nutrient utilization, intestinal morphology, slaughter performance, and meat quality of finishing pigs using fermented corn straw (FCS) as the fiber source. The experiment employed a 2 × 4 factorial design, selecting 96 Songliao Black (SLB) and Duroc × Landrace × Yorkshire (DLY) crossbred finishing pigs (a total of 192 pigs, with an initial body weight of 60.52 ± 4.

In-situ Sprayed platelet-derived small extracellular vesicles for the skin flap survival by reducing PANoptosis.

Necrosis at the distal end of random skin flaps remains a significant challenge, limiting the clinical application of these flaps in plastic and reconstructive surgery. Inhibiting ischemia/reperfusion (I/R) injury and promoting the formation of neovascular networks are critical preventive strategies. Platelet-derived small extracellular vesicles (PL-sEV) are nanocarriers of growth factors that provide an alternative to clinically used platelet-rich plasma and platelet lysates, offering higher growth factor concentrations and lower immunogenicity.

Pharmacological and toxicological characteristics of baicalin in preventing spontaneous abortion and recurrent pregnancy loss: A multi-level critical review.

Relevance: Spontaneous abortion (SAB) and recurrent pregnancy loss (RPL) occur alone or concurrently with increasing incidences recently. Scutellaria baicalensis Georgi (SBG) has been used to prevent pregnancy loss for thousands of years, which is recognized as a "pregnancy-stabilizing herb" in ancient China. Baicalin (BA) and its metabolite baicalein (BE) are the main bioactive flavonoids in the root of SBG.

Three-step surface design of spore-displayed keratinase improved acid tolerance and feather degradation.

The global chicken business has grown rapidly, producing millions of tons of feather waste annually. Keratinase is a special enzyme that catalyzes the degradation of keratin and can be applied to the feed industry. In this study, we initially set the tone for the acid-resistant mutation of spore surface-display keratinase cotG-KERQ7 by replacing base-catalytic residues in the active center.

Effects of Dietary Fiber and Copper on the Performance and Gut Microbiota of Finishing Pigs.

This study aimed to investigate the effects of dietary fiber (DF) levels and copper concentrations on the production performance and cecal microbial diversity of finishing pigs. A 2 × 2 factorial experimental design was used, with different levels of dietary fiber (low [23% DF]: L and high [30% DF]: H) and copper concentrations (normal [25 mg/kg]: N and supplemented [45 mg/kg]: S) resulting in four diets (LN, LS, HN, and HS). Forty-eight hybrid barrows (Duroc × Landrace × Yorkshire), with an initial body weight of 76 kg ± 1.

Angiogenesis of Avascular Necrosis of the Femoral Head: A Classic Treatment Strategy.

Avascular necrosis of the femoral head (ANFH) is a type of osteonecrosis due to the cessation of blood supply, characterized by persistent local pain and collapse of the joint. The etiology of ANFH is multifaceted, and while its precise pathogenesis remains elusive, it is currently widely believed that the femoral head is highly dependent on the vascular system. A large number of studies have shown that vascular injury is the initial factor in the onset of ANFH.

GnuR Represses the Expression of Glucose and Gluconate Catabolism in Pseudomonas putida KT2440.

In Pseudomonas putida KT2440, a prime chassis for biotechnology, the clustered distribution of glucose catabolism genes and four related transcription factors (TFs) may facilitate the tight regulation of glucose catabolism. However, the genes under the direct control of these TFs remain unidentified, leaving their regulatory roles elusive. Furthermore, the carbon source gluconate was metabolised similarly to glucose in KT2440, but the responses of these catabolic and TF genes to gluconate were unclear.

[Application of interrupter resistance pulmonary function testing in the diagnosis of asthma in preschool children: a single-center study].

Objectives: To investigate the value of interrupter resistance (Rint) pulmonary function testing in the diagnosis of asthma in preschool children, and to compare the significance of Rint pulmonary function testing versus impulse oscillometry (IOS) in the diagnosis of asthma.

Methods: A prospective study was conducted among 108 children with recurrent wheezing, aged 4 to <6 years, who were admitted from July 2022 to November 2023. According to the treatment outcome, they were divided into an asthmatic group (61 children) and a non-asthmatic group (47 children).

A Comprehensive Bibliometric Analysis and Visualization of Publication Trends in Hip-Spine Syndrome.

Objective: Hip-spine syndrome (HSS) was first described in 1983 as a syndrome characterizing the concurrent symptoms of lumbar and hip joint degenerative disease. This study aims to elucidate the research trends, hot topics, and influential publications in HSS through bibliometric analysis.

Methods: The Web of Science database was used to search for all literature on HSS from 1983 to 2024.

Real-Time Surgical Planning for Cerebral Aneurysms Treated With Intrasaccular Flow Disruption Devices Based on Fast Virtual Deployment and Discrete Element Method.

This study introduces an innovative real-time surgical planning platform optimized for the treatment of arterial aneurysms using intrasaccular flow disruption (IFD) devices. This platform incorporates a cutting-edge fast virtual deployment (FVD) algorithm alongside a discrete element method (DEM) for computational fluid dynamics (CFD) analyses. It facilitates the efficient virtual deployment of IFD devices, minimizing computational overhead while allowing for comprehensive postoperative hemodynamic efficacy assessment.