Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma.

Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.

Objective: We aimed to identify ICB resistance-associated druggable histone deacetylases (HDACs) and develop a readily translatable combination approach for patients with hepatocellular carcinoma (HCC).

Revealing the mechanism of bifunctional PtLa electrocatalyst for highly efficient methanol oxidation, hydrogen evolution, and coupling reaction.

The development of clean energy solutions, such as fuel cells and hydrogen energy, is crucial for addressing the global energy shortage. Platinum (Pt)-based catalysts are widely used in fuel cells and hydrogen energy generation (for example, via water electrolysis). However, reducing the amount of Pt used while maintaining the catalytic performance of such catalysts is essential.

Composite Learning Based Adaptive Control of Linear 2×2 Hyperbolic PDE Systems.

This article considers the adaptive stability control of a class of 2×2 linear hyperbolic PDE systems. The PDE model is subject to constant but in-domain and boundary unknown parameters. A novel adaptive controller is developed by leveraging the swapping design technique and composite parameter learning law.

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs.

Mechanisms controlling the movement of the cerebrospinal fluid (CSF) toward peripheral nerves are poorly characterized. We found that, in addition to the foramina Magendie and Luschka for CSF flow toward the subarachnoid space and glymphatic system, CSF outflow could also occur along periaxonal spaces (termed "PAS pathway") from the spinal cord to peripheral organs, such as the liver and pancreas. When interrogating the latter route, we found that serotonin, acting through 5-HT receptors expressed in ependymocytes that line the central canal, triggered Ca signals to induce polymerization of F-actin, a cytoskeletal protein, to reduce the volume of ependymal cells.

Energy-Based Skin Rejuvenation: A Review of Mechanisms and Thermal Effects.

Background: Energy-based photoelectric and ultrasonic devices are essential for skin rejuvenation and resurfacing in the field of plastic surgery and dermatology. Both functionality and appearance are impacted by factors that cause skin to age, and various energy types have variable skin penetration depths and modes of transmission.

Aim: The objective is to advise safe and efficient antiaging treatment while precisely and sensitively controlling and assessing the extent of thermal damage to tissues caused by different kinds of energy-based devices.

Changes in factor profiles deriving from photochemical losses of volatile organic compounds: Insight from daytime and nighttime positive matrix factorization analyses.

Substantial effects of photochemical reaction losses of volatile organic compounds (VOCs) on factor profiles can be investigated by comparing the differences between daytime and nighttime dispersion-normalized VOC data resolved profiles. Hourly speciated VOC data measured in Shijiazhuang, China from May to September 2021 were used to conduct study. The mean VOC concentration in the daytime and at nighttime were 32.

Cardiovascular disease modifies the relationship between systolic blood pressure and outcomes in people with diabetes.

Objective: We aimed to evaluate the influences of cardiovascular disease (CVD) on the relationship between baseline systolic blood pressure (SBP) and outcomes in community populations with diabetes.

Methods: This is an observational study of 16,431 community adults with diabetes. The relationship between SBP with major adverse cardiovascular event (MACE) and all-cause death were evaluated using multivariable-adjusted Cox proportional hazard models and restricted cubic spline.

Integrated metabolomics and network pharmacology analysis to reveal the protective effect of Complanatoside A on nonalcoholic fatty liver disease.

Introduction: The rising prevalence and severe consequences of nonalcoholic fatty liver disease (NAFLD) have driven the quest for preventive medications. Complanatoside A (CA) is the marked flavonoid of Astragali complanati semen, a traditional Chinese herb that acts on the liver meridian and is widely used to treat liver problems. CA has been proven to have considerable lipid-lowering and liver-protective effects in vitro.

Evolution of hydrochemistry and water quality of karst groundwater under the effects of intense anthropogenic activities.

Intense anthropogenic activities in a karst area will inevitably change the regional groundwater environment and affect the characteristics of the karst groundwater, such as the hydrochemistry and water quality. It is of great importance to study the evolution characteristics of the hydrochemistry and water quality of karst groundwater under intense anthropogenic activities to ensure the stability and sustainable development of karst ecosystems. In this study, a representative synclinal basin-type karst groundwater system in northern China was used as the study object, and the effects of intense anthropogenic activities on the evolution of the hydrochemistry and water quality of the karst groundwater were analyzed using a comprehensive application of a groundwater quality assessment, a multivariate statistical analysis, a hydrogeochemical analysis, and multi-factor regime monitoring of the karst groundwater quality.

Toward Ultrathin: Advances in Solution-Processed Organic Semiconductor Transistors.

In recent years, organic semiconductor (OSC) ultrathin films and their solution-processed organic field-effect transistors (OFETs) have garnered attention for their high flexibility, light weight, solution processability, and tunable optoelectronic properties. These features make them promising candidates for next-generation optoelectronic applications. An ultrathin film typically refers to a film thickness of less than 10 nm, i.

Predictive Value of Triglyceride-Glucose Index for All-Cause and Cardiovascular Mortality in Patients With Diabetes Mellitus: A Retrospective Study: TyG Index and Mortality in Diabetes.

To determine the associations between triglyceride-glucose (TyG) index and mortality from all causes and cardiovascular causes in diabetic population. 3349 participants with diabetes mellitus (DM) from the 1999-2014 National Health and Nutrition Examination Surveys (NHANES), aged 18-85 years were included and grouped based on the TyG index in quintiles. Mortality was followed up through December 31, 2015.

Evaluation of Inflammatory Markers in Patients with COVID-19 Combined with Type 2 Diabetes Mellitus.

Purpose: To explore the value of different inflammatory markers in predicting the severity of coronavirus disease 2019 (COVID-19) in patients with type 2 diabetes mellitus (T2DM).

Patients And Methods: A total of 116 patients with COVID-19 in patients with T2DM were collected from December 2022 to March 2023 and were divided into a mild case group (77 cases) and a severe case group (39 cases). The ratio of neutrophil to lymphocyte (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil to lymphocyte × platelet ratio (NLPR), lymphocyte ratio to monocyte (LMR), systemic inflammatory response index (SIRI), systemic inflammatory index (SII), systemic inflammatory composite index (AISI), procalcitonin (PCT), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were compared between the two groups.

Association Between Pericoronary Fat Attenuation Index as Evaluated by Coronary Artery CT Angiography and Clinical Interventions in Lipid Management Among Patients with Coronary Artery Disease.

Objective: This study aims to evaluate the relationship between the pericoronary fat attenuation index (FAI), derived from coronary artery computed tomography angiography, and post-lipid management levels of low-density lipoprotein cholesterol in patients with coronary artery disease (CAD). Additionally, the study investigates coronary inflammation across different lipid management strategies.

Methods: We selected a cohort comprising 521 CAD patients who met the inclusion criteria.

Efficient Growth of 1D Van der Waals Heterostructures on Zeolite-Supported SWCNTs.

The controlled synthesis of 1D van der Waals (1D vdW) heterostructures, specifically single-walled carbon nanotubes encapsulated within boron nitride nanotubes (SWCNT@BNNT), presents a challenge due to an incomplete understanding of the factors influencing BNNT growth. This study investigates the growth yield of SWCNT@BNNT heterostructures produced using zeolite-supported SWCNT templates on SiO-coated Transmission Electron Microscopy (TEM) grids, which enable in situ synthesis and thorough evaluation of each step without compromising the nanotube structure. The high-resolution TEM analysis reveals a significant improvement in BNNT coverage on individual nanotubes, increasing from 9% to 42%, through optimization of the ammonia borane precursor amount.

Deep learning models for hepatitis E incidence prediction leveraging Baidu index.

Background: Infectious diseases are major medical and social challenges of the 21 century. Accurately predicting incidence is of great significance for public health organizations to prevent the spread of diseases. Internet search engine data, like Baidu search index, may be useful for analyzing epidemics and improving prediction.

Global emergence of Escherichia coli with PBP3 insertions.

Objectives: Escherichia coli producing metallo-β-lactamases with penicillin-binding protein 3 (PBP3) insertions have reduced susceptibility to aztreonam-avibactam and cefiderocol. Here, we analysed high-quality E. coli genomes for PBP3 insertions.

Single phage proteins sequester signals from TIR and cGAS-like enzymes.

Prokaryotic anti-phage immune systems use TIR and cGAS-like enzymes to produce 1''-3'-glycocyclic ADP-ribose (1''-3'-gcADPR) and cyclic dinucleotide (CDN) and cyclic trinucleotide (CTN) signalling molecules, respectively, which limit phage replication. However, how phages neutralize these distinct and common systems is largely unclear. Here we show that the Thoeris anti-defence proteins Tad1 and Tad2 both achieve anti-cyclic-oligonucleotide-based anti-phage signalling system (anti-CBASS) activity by simultaneously sequestering CBASS cyclic oligonucleotides.

Scaffold hopping approach to the novel hexacyclic pyrazol-3-amide derivatives as potential multi-target insect growth regulators candidates.

Ecdysone receptor (EcR) and three insect chitinases (OfChtI, OfChtII, and OfChi-h) are considered as attractive targets for the development of novel insect growth regulators (IGRs) since they are closely related to the insect molting. In this study, to develop potent multi-target IGRs, a series of hexacyclic pyrazol-3-amide derivatives were rationally designed by utilizing the scaffold hopping strategy with the previously reported compound 6j (N-(4-bromobenzyl)-2-phenyl-4,5,6,7-tetrahydro-2H-indazole-5-carboxamide) as a lead compound. The bioassay results indicated that most of the target compounds exhibited obvious insecticidal activity.

Calcium alginate/Polyaniline double network aerogel electrode for compressible and high electrochemical performance integrated supercapacitors.

As a new type of energy storage device, supercapacitors have attracted more and more attention due to their excellent performance. However, the current electrode materials have limited specific surface area and cannot meet the needs of high energy storage. The aerogel material is a 3D network structure containing interconnected micro-nano structures, and also has hierarchical pores on the micro, meso and macro scales.