Joint Fault Diagnosis of IGBT and Current Sensor in LLC Resonant Converter Module Based on Reduced Order Interval Sliding Mode Observer.

LLC resonant converters have emerged as essential components in DC charging station modules, thanks to their outstanding performance attributes such as high power density, efficiency, and compact size. The stability of these converters is crucial for vehicle endurance and passenger experience, making reliability a top priority. However, malfunctions in the switching transistor or current sensor can hinder the converter's ability to maintain a resonant state and stable output voltage, leading to a notable reduction in system efficiency and output capability.

Multi-Element Fingerprinting Combined with Chemometrics for Identification of Seaweeds and Innovative Risk-Benefit Assessment.

Seaweeds are one of the major marine foods with high values. The diversity of seaweed species significantly impacts their quality and is closely linked to their purity and safety. For the first time, this study established a model to discriminate seaweed species using a multi-element fingerprinting approach for species identification.

Mass Spectrometry-Based Metabolomics Investigation on Two Different Seaweeds Under Arsenic Exposure.

Arsenic is a common toxic heavy metal contaminant that is widely present in the ocean, and seaweeds have a strong ability to concentrate arsenic, posing a potential risk to human health. This study first analyzed the arsenic content in two different seaweeds and then used an innovative method to categorize the seaweeds into low-arsenic and high-arsenic groups based on their arsenic exposure levels. Finally, a non-targeted metabolomic analysis based on mass spectrometry was conducted on seaweed from different arsenic exposure groups.

Mechanism of Irrigation Before Low-Temperature Exposure on Mitigating the Reduction in Yield Loss and Spikelet Abortion at the Jointing Stage of Wheat.

The increasing frequency of low-temperature events in spring, driven by climate change, poses a serious threat to wheat production in Northern China. Understanding how low-temperature stress affects wheat yield and its components under varying moisture conditions, and exploring the role of irrigation before exposure to low temperatures, is crucial for food security and mitigating agricultural losses. In this study, four wheat cultivars-semi-spring (YZ4110, LK198) and semi-winter (ZM366, FDC21)-were tested across two years under different conditions of soil moisture (irrigation before low-temperature exposure (IBLT) and non-irrigation (NI)) and low temperatures (-2 °C, -4 °C, -6 °C, -8 °C, and -10 °C).

Pathogenicity of tick-derived lymphocytic choriomeningitis virus in BALB/c mice.

Background: Lymphocytic choriomeningitis virus (LCMV) is a zoonotic pathogen primarily transmitted by rodents. Recently, LCMV has been detected in ticks from northeastern China; however, the pathogenicity of this virus in murine models remains to be elucidated.

Results: Here, we examined the tick-derived LCMV strain JX14 by inoculating BALB/c mice with 3.

Deficiency of Endothelial Impairs Pulmonary Vascular Angiogenesis and Predisposes Pulmonary Hypertension.

Background: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.

Methods: Endothelial cell (EC)-specific knockout (, Tek-Cre; ) rats and primarily cultured pulmonary microvascular ECs were used to determine the role of Piezo2 in PH.

MGB probe-based multiplex droplet digital PCR for the interspecific identification of Notopterygii Rhizoma et Radix in herbal materials and preparations.

Background: Owing to high sensitivity and ability for absolute quantification, the droplet digital polymerase chain reaction (ddPCR) is widely used for viral and bacterial detection. However, few studies have been conducted on the application of ddPCR to identify the original plant species used in traditional Chinese medicine and Chinese patent medicine.

Purpose: In this study, we investigated the feasibility of using ddPCR to differentiate between Notopterygium incisum and N.

Development and Validation of a Nomogram-Based Model to Predict Primary Hypertension Within the Next Year in Children and Adolescents: Retrospective Cohort Study.

Background: Primary hypertension (PH) poses significant risks to children and adolescents. Few prediction models for the risk of PH in children and adolescents currently exist, posing a challenge for doctors in making informed clinical decisions.

Objective: This study aimed to investigate the incidence and risk factors of PH in Chinese children and adolescents.

Aquatic high iron induces hepatic ferroptosis in zebrafish (Danio rerio) via interleukin-22 signaling pathway.

Iron is one of the indispensable trace elements in living organisms. However, excessive iron deposition in organisms is prone to induce dysfunction of the liver and other vital organs. The present study aimed to investigate the mechanism how aquatic high iron affects iron transport and induces hepatic injury in zebrafish.

Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China.

Objective: The aim of this study was to explore the clinical characteristics of patients infected with different Omicron subvariants presenting non-severe disease, evaluate the safety and efficacy of Azvudine for treatment of COVID-19, in order to broaden understanding of Omicron subvariant infections.

Method: A total of 244 individuals with Omicron subvariant (BA.2.

Adaptive deep feature representation learning for cross-subject EEG decoding.

Background: The collection of substantial amounts of electroencephalogram (EEG) data is typically time-consuming and labor-intensive, which adversely impacts the development of decoding models with strong generalizability, particularly when the available data is limited. Utilizing sufficient EEG data from other subjects to aid in modeling the target subject presents a potential solution, commonly referred to as domain adaptation. Most current domain adaptation techniques for EEG decoding primarily focus on learning shared feature representations through domain alignment strategies.

The structure and assembly of the hetero-octameric BLOC-one-related complex.

BORC (BLOC-one-related complex) is a hetero-octameric complex, consisting of eight coiled-coil proteins (BORCS1-8). BORC controls lysosomal and synaptic vesicle transport and positioning by recruiting ARL8. The structural mechanisms underlying BORC assembly and ARL8 activation remain unclear.

Preoperative D-dimer level predicts adverse events after coronary endarterectomy combined with coronary artery bypass grafting: a retrospective cohort study.

Background: Little is known about the role of D-dimer (DD) on the prognosis of patients undergoing coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG).

Methods: A total of 371 patients undergoing CE with CABG between January 2018 and July 2022 were retrospectively enrolled. The primary endpoint was the perioperative major adverse cardiovascular and cerebrovascular events (MACCE).

Development of a DNA-encoded library screening method "DEL Zipper" to empower the study of RNA-targeted chemical matter.

To date, RNA-targeted chemical matter is under explored due to a lack of robust screening assays. In this study, we present a novel RNA-targeted small molecule screening approach using a specialized DNA-encoded library (DEL). Our findings reveal that the specialized DEL library, called "DEL Zipper", can significantly reduce single-stranded DNA-RNA region interaction signals during various kinds of RNA selection.

Cephalopod-Inspired MXene-Integrated Mechanochromic Cholesteric Liquid Crystal Elastomers for Visible-Infrared-Radar Multispectral Camouflage.

Multispectral camouflage materials play a vital role in sophisticated multi-band electromagnetic (EM) applications. However, conventional single-band stealth is difficult to align with the growing demand for multi-band compatibility and intelligent adaptation. Herein, we report the design and synthesis of cephalopod-inspired MXene-integrated cholesteric liquid crystal elastomers (MXene-CLCEs) with multispectral camouflage capability, which was fabricated through in situ thiol-acrylate Michael addition and free-radical photopolymerization of CLCE precursor and isocyanate-mediated robust covalent chemical bonding of MXene nanocoating at the interface.

Risk factors and simple scoring system for predicting postoperative nutritional status of Hirschsprung's disease.

Background: Nutritional problem after surgery for Hirschprung's disease (HSCR) was not optimistic. This study aimed to analyze the risk factors of postoperative undernutrition for patients with HSCR and establish a scoring system for predicting postoperative undernutrition.

Methods: Retrospective review of 341 patients with HSCR who received Laparoscopic-assisted pull-through surgery in a tertiary-level pediatric hospital was conducted with assessments of clinical data.

Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.

Cardiac regeneration involves the interplay of complex interactions between many different cell types, including cardiomyocytes. The exact mechanism that enables cardiomyocytes to undergo dedifferentiation and proliferation to replace lost cells has been intensely studied. Here we report a single nuclear RNA sequencing profile of the injured zebrafish heart and identify distinct cardiomyocyte populations in the injured heart.

Preserving one artery shortens the surgical time and does not affect the efficacy of microsurgical subinguinal varicocelectomy: preliminary findings from a retrospective study.

Background: To analyze the safety and efficacy of microsurgical subinguinal varicocelectomy(MSV) performed with and without preservation of all testicular arteries and lymphatic system.

Methods: All of the 98 patients with varicocele who underwent MSV were included in the analysis. Fifty-eight male patients surgically underwent MSV with preservation of all testicular arteries and lymphatic system(Group 1).

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation.

Background: Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. To advance our understanding of the pathogenesis of functional MR, it is crucial to characterize the cellular composition of the mitral valve leaflet and identify molecular changes in each cell subtype within the mitral valves of MR patients. Therefore, we aimed to comprehensively examine the cellular and molecular components of mitral valves in patients with MR.

High-Performance Flexible Strain Sensors: The Role of In-Situ Cross-Linking and Interface Engineering in Liquid Metal-Carbon Nanotube-PDMS Composites.

The increasing demand for high-performance strain sensors has driven the development of innovative composite systems. This study focused on enhancing the performance of composites by integrating liquid metal, carbon nanotubes, and polydimethylsiloxane (PDMS) in an innovative approach that involved advanced interface engineering, filler synergy, and in situ cross-linking of PDMS in solution. Surface modification of liquid metal with allyl disulfide and hydrogen-containing polydimethylsiloxane significantly improved its stability and dispersion within the polymer matrix.

Screening of ESR2-targeted anti-postmenopausal osteoporosis chemistry from Rehmanniae Radix Preparata based on affinity ultrafiltration with UPLC-QE-Orbitrap-MS.

Rehmanniae Radix Preparata, a processed form of the traditional Chinese medicinal plant Rehmannia glutinosa Libosch, has long been valued for its medicinal properties and use as a food. It is notably effective in treating postmenopausal osteoporosis. This study utilized C18 to separate and purify different concentrations of its eluent streams.

A phase III randomized controlled non-inferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) versus piperacillin/tazobactam (PIP/TAZ) in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Objectives: Imipenem/cilastatin/relebactam (IMI/REL) is a β-lactam/β-lactamase inhibitor combination effective against gram-negative pathogens. Efficacy and safety of IMI/REL were studied in critically ill adults with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Methods: In this phase III, double-blind, multinational, randomized trial (NCT03583333), adults with HABP/VABP were randomized 1:1 to receive intravenous IMI/REL (500 mg/250 mg) or piperacillin/tazobactam (PIP/TAZ; 4000 mg/500 mg) every 6 h for 7-14 days.

Analysis of the bamboo SWEET gene family reveals that Dendrocalamus farinosus SWEET14 is involved in source-sink carbohydrate partitioning.

In higher plants, SWEET genes play a crucial role in source-sink carbohydrate partitioning. Dendrocalamus farinosus is an economic bamboo species because of its high fiber content and rapid growth. The transportation of photosynthetic products is essential for bamboo growth.