Monocarboxylic Acid Structural Analogues Facilitate In Situ Composite of Functional Complexes for Aqueous Batteries.

In situ composite methods have aroused research interest in materials science and acted as a novel strategy to achieve structural tailoring of materials. However, the controllable preparation of composites containing functional groups remains a challenge. Herein, we report an approach based on competitive coordination between structural analogues, by which the functionally composite metal complex (NiSH@Ni-FSA) was synthesized.

Efficacy of Xuanbai Chengqi decoction combined with western medicine in treating AECOPD with phlegm-heat obstructing lung syndrome: a clinical study.

Objective: To explore the efficacy of Xuanbai Chengqi Decoction combined with conventional Western medicine in the treatment of AECOPD patients with phlegm-heat obstructing the lung syndrome.

Methods: A retrospective analysis was conducted on the clinical data of 166 patients with this syndrome admitted to our hospital between December 2023 and March 2024. Patients were divided into a study group (Xuanbai Chengqi Decoction + conventional Western medicine treatment, 83 cases) and a control group (conventional Western medicine treatment, 83 cases).

Identification of a target polypeptide of the CD169 receptor of bovine macrophage using a phage display peptide library.

CD169, a salivary acid adhesion receptor on macrophages, plays a crucial role in enhancing the phagocytic response to pathogenic bacteria and in antibacterial immunity. To explore its potential in targeted veterinary drug applications, we used phage display technology to biopan peptide fragments specific to CD169. After several rounds of screening, 45 phage clones were selected for ELISA testing, resulting in 21 high-affinity clones.

Suture Anchor and Reverse Suture Anchor show Superior Biomechanical Efficacy to Transtibial Pull-out Repair for Posterior Medial Meniscus Root Tears in Porcine Model.

Purpose: To investigate the biomechanical efficacy of the reverse suture anchor (RSA) technique compared with the transtibial pull-out (TP) and suture anchor (SA) techniques using in vitro porcine knee models of PMMRTs.

Methods: 32 fresh frozen porcine tibiae with medial meniscus intact were randomly assigned to four groups (eight specimens each). A standardized posterior medial meniscus root tear (PMMRT) was established in 24 specimens.

Molecule-induced ripening control in perovskite quantum dots for efficient and stable light-emitting diodes.

Perovskite quantum dots (QDs) show an excellent application perspective in semiconductor optoelectronic devices. However, problems of ligand loss during the growth, purification, film formation, and storage process always induce the aggregation and ripening of QDs, adversely affecting QDs' and QD-based devices' performance. Here, we use a bidentate molecule to control ripening toward a notable performance boost in CsPbI QDs.

Box-like Molecules-Induced Discrete Ring-in-Rings Assembly of Hydrogen-Bonded Aramide Macrocycles.

The controlled formation of ring-in-ring(s) assemblies is highly desirable as precursors for constructing high order supramolecular architectures. We report our findings that this goal can be achieved by balancing molecular structures and conformational adaptivity through an interplay of multiple non-covalent bonding interactions. With H-bonded aramide macrocycles and box-like molecules including naph-Box, m-Box and p4p-Box, ring-in-rings assembling systems with 4 : 1 stoichiometry are preferentially created.

Partial Differential Equations Meet Deep Neural Networks: A Survey.

Many problems in science and engineering can be mathematically modeled using partial differential equations (PDEs), which are essential for fields like computational fluid dynamics (CFD), molecular dynamics, and dynamical systems. Although traditional numerical methods like the finite difference/element method are widely used, their computational inefficiency, due to the large number of iterations required, has long been a challenge. Recently, deep learning (DL) has emerged as a promising alternative for solving PDEs, offering new paradigms beyond conventional methods.

Exploring novel biomarkers and immunotherapeutic targets for biofeedback therapies to reveal the tumor-associated immune microenvironment through a multimetric analysis of kidney renal clear cell carcinoma.

Background: Kidney renal clear cell carcinoma (KIRC) constitutes the primary subtype of renal cell carcinoma, representing 75% to 80% of cases and carrying a substantial cancer-specific mortality rate of up to 24%. Despite advancements in treatment options, KIRC displays notable resistance to conventional therapies, emphasizing the need for innovative targeted immunotherapeutic strategies. Chromatin regulators (CRs), pivotal proteins controlling gene expression and critical biological processes, play a crucial role in the initiation and progression of KIRC.

Identification and Molecular Mechanism of Novel α-Glucosidase Inhibitory Peptides from the Hydrolysate of Hemp Seed Proteins: Peptidomic Analysis, Molecular Docking, and Dynamics Simulation.

There is a growing demand for natural and potent α-glucosidase inhibitors due to the rising prevalence of diabetes. In this study, newly identified α-glucosidase inhibitory peptides were identified from the tryptic hydrolysate of hemp seed proteins based on peptidomics and in silico analysis. A total of 424 peptides, primarily derived from four cupin-type-1 domain-containing proteins, were identified, and 13 ultimately were selected for validation based on their higher PeptideRanker scores, solubility, non-toxicity, and favorable ADMET properties.

Occurrence, sources, and risks of microplastics in agricultural soils of Weishan Irrigation District in the lower reaches of the Yellow River, China.

Microplastics (MPs) have been widely detected in the soil environment. The Weishan Irrigation District is the largest irrigation area in the lower reaches of the Yellow River. However, little is known about MP pollution levels in the soils of this area.

A new pyrrolopyrazine alkaloid from the fruit of .

A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.

Sex differences in the relationship between body mass index in Chinese adolescents and future risk of hypertension: a decade-long cohort study.

Objective: This study aimed to investigate the relationship between body mass index (BMI) during adolescence and the future risk of developing hypertension, with a particular focus on potential sex differences.

Methods: This study was a secondary analysis based on a cohort study involving 2,020 adolescents aged 10-15 years who underwent health check-ups at the MJ Health Screening Center between 1999 and 2008. Cox proportional hazards regression models were used to evaluate the association between BMI and hypertension risk, with stratification by gender.

Asiatic acid in anticancer effects: emerging roles and mechanisms.

Medicinal plants are crucial in the comprehensive treatment of anti-tumor with the advantages of high efficacy, low toxicity, multiple pathways and multi-targets synergy, leading to be a focal point of study for many oncologists. Identifying effective monomer components with anti-tumor properties from medicinal plants has long been a crucial focus in the study and development of traditional Chinese medicine. This endeavor has significant research value and promising possibilities for further advancement.

Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes.

Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding Z-configuration deuterated alkene products.

Genetic evidence of methotrexate's protective role against Parkinson's disease: A Mendelian randomization and co-localization study.

Background: Recent research has indicated a possible link between the use of methotrexate (MTX) and a heightened risk of developing Parkinson's disease (PD). Nevertheless, the causal relationship between MTX and PD continues to be unclear. This study aimed to explore the potential causal impact of MTX use on the risk of PD by employing two-sample Mendelian randomization (MR) alongside co-localization (COLOC) analysis.

A Nd-Yb ratiometric luminescent nanothermometer for assessing thermal resistance discrepancies between A549 and BEAS-2B cells to achieve selective hyperthermia.

Temperature is a crucial physical parameter in living organisms, directly associated with cellular activities. Elevated temperatures induce cell death, thereby establishing hyperthermia as a viable modality for cancer therapy. The demand for determining appropriate cancer types for hyperthermia lies in identifying cancer cells that exhibit poorer heat tolerance compared to normal cells.

Phototherapeutic activity of polypyridyl ruthenium(II) complexes through synergistic action of nitric oxide and singlet oxygen.

In recent years, photodynamic therapy (PDT) and gas therapy (GT) have emerged as research hotspots due to their excellent cancer treatment efficacy. By combining the advantages of both, the simultaneous and controllable release of reactive oxygen species (ROS) and nitric oxide (NO) has become a possibility. This paper describes the design of two Ru(II) complexes, [Ru(bpy)(NFIP)](PF) (Ru1, bpy = 2,2'-bipyridine, NFIP = 4-nitro-3-trifluoromethylaniline-1-imidazo[4,5-][1,10]phenanthroline) and [Ru(phen)(NFIP)](PF) (Ru2, phen = 1,10-phenanthroline), through the integration of the polypyridyl ruthenium structure and a photoresponsive NO donor.

Development of a nomogram model for predicting dementia risk in the older adult population of Weifang, Shandong Province, China: based on the biopsychosocial model.

Background: Dementia has emerged as a predominant health challenge. However, there is a notable research gap in the collective screening of dementia risks. Hence, there is a pressing need to formulate a dementia prediction tool tailored to the older adult demographic, enabling the identification of high-risk individuals for dementia.

Macrophage-targeting Antisenescence nanomedicine enables in-Situ NO induction for Gaseous and antioxidative atherosclerosis intervention.

Senescent-endothelial cells significantly accelerate atherosclerosis progression, making the mitigation of cellular aging a promising strategy for treating the disease. Nitric oxide (NO), a low molecular weight and lipophilic gas, has been shown to penetrate cell membranes effectively and delay cell senescence. In this study, we designed and engineered osteopontin (OPN)-modified nanoliposomes (CZALO) that encapsulate L-arginine (L-Arg) and cerium-zirconium oxide nanoparticles (CZ NPs), which exhibit enzyme-like activities for targeted atherosclerosis treatment.

LncRNA-MALAT1 promotes triple-negative breast cancer progression and function as ceRNA to target REEP5 by sponging miR-106a-5p.

Axillary lymph node metastasis (ALNM) in triple negative breast cancer (TNBC) will lead to poor prognosis. Recent studies have shown that long non-coding RNAs (lncRNAs) were involved in the progression of tumors. This study aimed to explore the role and mechanism of lncRNA-MALAT1 in the progression of TNBC and its relationship with ALNM.

K/Cl Dual-Mediated Spatial Charge Separation in Carbon Nitride Boosts Piezocatalytic Pure Water Splitting.

Graphite-phase carbon nitride is regarded as a highly promising piezoelectric catalyst, yet its interlayer and in-plane charge transfer capabilities pose significant limitations to its application. Graphite-phase carbon nitride is regarded as a highly promising piezoelectric catalyst, yet its interlayer and in-plane charge transfer capabilities pose significant limitations to its application. In this study, Cl, K co-modulated carbon nitride was synthesized via the molten salt method.

Material basis and mechanism of Ephedra sinica in interfering with wind-chill cold.

Ephedra sinica has a long history in medicine, i.e., as the first medicinal plant for treating wind-chill colds.

2-Methoxybenzoic acid ameliorates arterial thrombosis via inhibiting carbon anhydrase activity in platelet.

Background: 2-Methoxybenzoic acid (2MOA) is a natural compound with potential salicylate-like effects; however, its impact on arterial thrombosis remains unclear. This study aims to investigate the effects of 2MOA on thrombogenesis and its underlying mechanisms.

Methods: FeCl-induced carotid artery injury and laser-induced cremaster artery injury thrombosis assays were utilized to explore the effect of 2MOA on thrombogenesis in vivo.

Nanowire-Activated Formation of Coaxial Core-Shell Nanostructure Encapsulated by Carbon Nanotube.

Molecular dynamics simulations have unveiled the atomic-scale mechanisms underlying the formation of core-shell nanostructures involving nanowires (NWs) and graphene. Our study identifies two pivotal steps in this process: the self-scrolling of graphene around NWs and the subsequent edge connection to form carbon nanotubes (CNTs). The tendency of graphene to scroll is governed by the complex interplay of van der Waals forces.