Publications by authors named "Feng Ruo Fei"
Article Synopsis
- Lipogenesis in porcine adipocytes is regulated by transcription factors ChREBP and SREBP-1c in response to glucose and insulin, with ChREBP primarily mediating glucose-induced lipogenesis.
- When ChREBP is silenced, glucose-induced lipogenesis drops by about 70%, while insulin-induced lipogenesis remains unchanged, revealing distinct pathways for these two stimuli.
- LXRα also plays a role in promoting lipogenesis, potentially via SREBP-1c, as it enhances lipogenesis when both ChREBP and SREBP-1c activities are inhibited, indicating that LXRα can directly mediate glucose- and insulin-induced lipogenesis.
Glucose is a substrate for fatty acid synthesis, and induces lipogenesis and expressions of lipogenic genes. It was proposed that transcriptional factor ChREBP, LXRα and SREBP-1c are key mediators in lipogenesis induced by glucose, however the underlying mechanism remains unclear in porcine adipocytes. In this study, glucose stimulated lipogenesis and expressions of ChREBP, LXRα, SREBP-1c and lipogenic genes FAS and ACC1 in primary porcine adipocytes.
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