Publications by authors named "Feng Long"

Purpose: The incidence and mortality of hepatocellular carcinoma are still high according to National Cancer Center of China. Atezolizumab plus bevacizumab has become one of the standard regimens for the first-line treatment of unresectable hepatocellular carcinoma. However, some patients still use lenvatinib in combination with immunotherapy instead of a standard "atezolizumab-bevacizumab" regimen as a lower risk of bleeding in patients with esophagogastric varices.

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Antibiotic resistance or tolerance of pathogens has become one of the global public crises. Finding new drug targets may open up a way of infection control. Phenazine pyocyanin (PYO) is an important virulence factor produced by the pathogen Pseudomonas aeruginosa.

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Motivated by "bamboo as a substitute for plastic (BASP)" initiative, replacing plastic products with bamboo attracted worldwide attention. However, the BASP products often suffered from mechanical failure under freeze-thaw process, during which varying cellulose supramolecular structure played a critical role. Herein, the structural evolution of supramolecular for cellulosic models including bamboo fiber, parenchyma and pulps were carefully determined during successive freeze-thaw-pyrolyzing process (-80 °C-1600 °C).

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Background: Skin photoaging caused by ultraviolet rays (UVR) not only affects the appearance, but also leads to benign and malignant skin tumors. Vicenin-2, a bioflavonoid, exhibits anti-UVB properties, but its potential in preventing skin photoaging and the underlying mechanisms remain unclear. This study aims to elucidate the molecular mechanisms of Vicenin-2 in treating photoaging through network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation.

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Glioblastoma multiforme (GBM) is the most malignant brain tumor, with radiotherapy frequently employed following surgical resection. However, conventional radiation therapies often yield suboptimal results. This study investigated the effects of X-ray and carbon ion irradiation on the glioblastoma cell line U251 to assess the distinctive advantages of carbon ion treatment and explore mechanisms for overcoming radiation resistance.

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Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a notably common complication in pediatrics, with an incidence rate ranging from 15 to 64%. This rate is significantly higher than that observed in adults. Currently, there is a lack of substantial evidence regarding the association between intraoperative blood pressure variability (BPV) during cardiac surgery with cardiopulmonary bypass (CPB) and the development of AKI in pediatric patients.

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Hot dry rock (HDR) geothermal development faces challenges due to the difficulty of stimulating fluid flow and heat-exchange fracture channels within deep, low-porosity, and low-permeability reservoirs. A liquid nitrogen cyclic cold shock method was proposed, using liquid nitrogen as a fracturing fluid. The large temperature difference between the liquid nitrogen and the hot rock induces thermal stress, forming a complex pore-fracture network.

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Designing catalysts with well-defined, identical sites that achieve site-specific selectivity, and activity remains a significant challenge. In this work, we introduce a design principle of topological-single-atom catalysts (T-SACs) guided by density functional theory (DFT) and Ab initio molecular dynamics (AIMD) calculations, where metal single atoms are arranged in asymmetric configurations that electronic shield topologically misorients d orbitals, minimizing unwanted interactions between reactants and the support surface. Mn/CeO catalysts, synthesized via a charge-transfer-driven approach, demonstrate superior catalytic activity and selectivity for NO removal.

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Canine coronavirus (CCoV), canine respiratory coronavirus (CRCoV), canine adenovirus type 2 (CAV-2), and canine norovirus (CNV) are important pathogens for canine viral gastrointestinal and respiratory diseases. Especially, co-infections with these viruses exacerbate the damages of diseases. In this study, four pairs of primers and probes were designed to specifically amplify the conserved regions of the CCoV M gene, CRCoV N gene, CAV-2 hexon gene, and CNV RdRp gene.

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Porcine astrovirus (PoAstV), porcine sapovirus (PoSaV), porcine norovirus (PoNoV), and porcine rotavirus A (PoRVA) are newly discovered important porcine diarrhea viruses with a wide range of hosts and zoonotic potential, and their co-infections are often found in pig herds. In this study, the specific primers and probes were designed targeting the ORF1 gene of PoAstV, PoSaV, and PoNoV, and the VP6 gene of PoRVA. The recombinant standard plasmids were constructed, the reaction conditions (concentration of primers and probes, annealing temperature, and reaction cycle) were optimized, and the specificity, sensitivity, and reproducibility were analyzed to establish a quadruplex real-time quantitative RT-PCR (RT-qPCR) assay for the detection of these four diarrheal viruses.

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Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3. The low expression level of HASs in normal keratinocytes and other various types of cells presents a recognized challenge, impeding biological and pathological research on their localization. In this study, the human proteins HAS1, HAS2, and HAS3 with fused maltose-binding protein (MBP) tags were successfully expressed at high levels and purified for the first time in HEK293F cells.

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Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

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Hot dry rock (HDR) is a novel green, low-carbon energy. Its development requires the creation of fracture channels in deep thermal reservoirs. Traditional methods such as hydraulic fracturing have limited effectiveness in reservoir stimulation, so a method of liquid nitrogen cold shock was proposed.

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Porcine hemagglutinating encephalomyelitis virus (PHEV), porcine pseudorabies virus (PRV), and classical swine fever virus (CSFV) are currently prevalent worldwide and cause similar neurological symptoms in infected pigs. It is very important to establish a detection method that can rapidly and accurately detect and differentiate these three viruses. Targeting the PHEV N gene, PRV gB gene, and CSFV 5' untranslated region (5'UTR), three pairs of specific primers and probes were designed, and a triplex crystal digital reverse transcription-PCR (cdRT-PCR) was developed to detect PHEV, PRV, and CSFV.

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Hot dry rock (HDR) geothermal is a sustainable and clean energy source. However, its development progress is hindered by creating seepage channels in deep reservoirs with low porosity and permeability. Traditional hydraulic fracturing techniques are ineffective for enhancing the permeability of these high-strength reservoirs.

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African swine fever virus (ASFV), classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), and porcine pseudorabies virus (PRV) induce similar clinical signs in infected pigs, including hyperthermia, anorexia, hemorrhage, respiratory distress, neurological symptoms, and/or abortions in pregnant sows. The differential diagnosis of these diseases relies on laboratory examinations. In this study, a quadruplex RT-qPCR was established using four pairs of specific primers and probes aimed at the (p72) gene of ASFV, the 5' untranslated region () of CSFV, the gene of PRRSV, and the gene of PRV for the detection and differentiation of ASFV, CSFV, PRRSV, and PRV.

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Article Synopsis
  • Mechanoluminescent (ML) materials are useful for mechanical sensing and monitoring but struggle with short emission lifetimes, limiting their practical use.
  • A new composite material combining CaNaMg(PO):Tb and poly(dimethylsiloxane) (PDMS) has been developed, allowing for self-activating persistent ML that responds to mechanical stimuli without needing prior irradiation.
  • This innovative material not only addresses the limitations of traditional ML systems but also demonstrates self-recovery and stability across a wide temperature range, broadening potential applications.
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A novel hybridization chain reaction (HCR) powered optical fiber-embedded microfluidic biochip (HCR-FMB) has been constructed for ultrafast and sensitive detection of lethal-7a (let-7a) in serum. By integrating HCR, fluorescence energy resonant transfer, and evanescent wave fluorescence principle, the HCR-FMB enables detecting let-7a with satisfactory limit of detection of 100.0 pM within 6 min at room temperature, and demonstrates excellent specificity.

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Article Synopsis
  • - Gastric cancer (GC) is a common and serious condition that affects the stomach lining and has high rates of illness and death, making effective diagnosis and treatment crucial.
  • - This study evaluated the treatment efficacy and safety of a chemotherapy regimen combining nab-paclitaxel with oxaliplatin and S-1 (P-SOX) compared to the standard SOX regimen in 219 patients with advanced GC over three years.
  • - The results indicated that the P-SOX regimen provided better short-term and long-term outcomes than SOX, with manageable side effects, suggesting it could become a preferred first-line treatment for GC patients.
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Cerium oxide (CeO) exhibits application potential for the selective catalytic reduction of nitrogen oxides (NO) with NH (NH-SCR). The crystal facets and morphology of CeO have a vital impact on the catalytic performance of NH-SCR. However, the precise influence mechanisms on SCR activity remain elusive.

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Background: Although goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) has been discussed extensively in adult studies, no pediatric indexed oxygen delivery (Doi) thresholds are universally accepted, and no pediatric randomized controlled trial has been reported. This study aimed to determine whether the GDP initiative (maintaining Doi ≥360 mL/min/m during CPB) could reduce the incidence of acute kidney injury (AKI) after pediatric cardiac operation and improve clinical outcomes.

Methods: This single-center randomized controlled trial enrolled 312 pediatric patients, who were randomized to receive either the GDP strategy or a conventional perfusion strategy during CPB.

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Article Synopsis
  • * Genetic analysis of 65 positive samples showed high nucleotide and amino acid similarities in the S, M, and N genes, indicating these strains are primarily CCoV-II genotype, with most being CCoV-IIa subtype.
  • * The research highlighted genetic diversity and ongoing evolution of CCoV strains, with evidence of recombination events and fluctuating population sizes over recent decades.
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Article Synopsis
  • * Genetic sequencing of 63 FCoV-positive samples revealed high homology among the S, M, and N genes, indicating evolutionary relationships between the strains.
  • * Phylogenetic analysis classified these strains as type I FCoV, showing high genetic diversity and recombinant signals, indicating ongoing prevalence and unique epidemic traits in the region.
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Article Synopsis
  • Porcine hemagglutinating encephalomyelitis virus (PHEV) is the only known coronavirus affecting pigs and is widespread; understanding its genetic traits is crucial for disease prevention and control.
  • In a study conducted in Guangxi, China, 6,986 samples were collected from 2021 to 2024, revealing a 2.81% positivity rate, with higher rates in nasopharyngeal swabs than tissue samples.
  • Genetic analysis showed significant homology among viral genes, indicating evolutionary diversity, with PHEV strains from Guangxi belonging to specific subgroups and demonstrating complex evolutionary paths since their emergence.
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