The evolution of S-nitrosylation detection methodology and the role of protein S-nitrosylation in various cancers.

S-nitrosylation (SNO) modification, a nitric oxide (NO)-mediated post-translational modification (PTM) of proteins, plays an important role in protein microstructure, degradation, activity, and stability. Due to the presence of reducing agents, the SNO modification process mediated by NO derivatives is often reversible and unstable. This reversible transformation between SNO modification and denitrification often influences the structure, activity, and function of proteins.

[Effect of simplified formula of Jinfukang Oral Liquid on apoptosis of renal tubular epithelial cells induced by cisplatin].

In order to study the effect of the simplified formula of Jinfukang Oral Liquid(ALG-12) on renal tubular injury induced by cisplatin(DDP), 48 C57 mice were divided into control group, model group, DDP group, and DDP combined with low, medium, and high dose groups of ALG-12. The mice were administered for 16 days after the establishment of the subcutaneous Lewis lung cancer heterotopic transplant tumor model of mice. The pathological changes, serum creatinine(Scr), blood urea nitrogen(BUN), kidney injury molecule 1(Kim-1), neutrophil gelatinase-associated lipocalin(NGAL), malondialdehyde(MDA), and total superoxide dismutase(T-SOD) in renal tissue and the degree of renal tubular cell apoptosis were analyzed to investigate the effect of ALG-12 on renal injury induced by DDP treatment on non-small cell lung cancer(NSCLC).

[A new idea for studying processing mechanism based on formation of supramolecular aggregates in traditional Chinese medicine decoctions].

Traditional Chinese medicines must be processed into decoction pieces before they can be used medicinally, and decoctions are the most common dosage form in TCM. Recent studies have shown that these decoctions are complex multiphase disperse systems containing supramolecular aggregates. These aggregates form through self-assembly interactions among chemical components du-ring the decocting process, in which hydrogen bonding, π-π interactions, van der Waals' forces, and hydrophobic interactions playing crucial roles.

A flexible, water anchoring, and colorimetric ionogel for sweat monitoring.

As water-saturated polymer networks, the easy water loss of hydrogels directly affects their end-use applications. Minimizing the ratio of free water and increasing the ratio of bound water in the gel system has become key to extending the service life. In this work, an ionogel is prepared that effectively regulates the proportion of free water and bound water through the formation of wrinkle angles by the hydrophilic and hydrophobic chains in the gel system and the non-volatile nature of the ionic liquid.

Multistage microfluidic assisted Co-Delivery platform for dual-agent facile sequential encapsulation.

The integration of multiple therapeutic agents within a single nano-drug carrier holds promise for advancing anti-tumor therapies, despite challenges posed by their diverse physicochemical properties. This study introduces a novel multi-stage microfluidic co-encapsulation platform designed to address these challenges. By carefully orchestrating the nano-precipitation process sequence, this platform achieves sequential encapsulation of two drugs with markedly different physicochemical characteristics.

Near-Wall Slow Flow Contributes to Wall Enhancement of Middle Cerebral Artery Bifurcation Aneurysms on Vessel Wall MRI.

The mechanism of aneurysm wall enhancement (AWE) in middle cerebral artery (MCA) bifurcation aneurysms on vessel wall magnetic resonance imaging (VW-MRI) remains unclear. We aimed to explore the morphologically related hemodynamic mechanism for the AWE of MCA bifurcation aneurysms. Patients with unruptured MCA bifurcation aneurysms undergoing VW-MRI were enrolled.

Retrospective analysis of prognostic factors in HICH patients after neuroendoscopic hematoma evacuation.

The objective of this study is to investigate key prognostic factors of clinical data and prognostic factors in patients with hypertensive intracerebral hemorrhage (HICH) who have undergone neuroendoscopic hematoma evacuation, specifically focusing on those with a hemorrhage volume of 20-40 mL, to identify the determinants influencing their prognosis. In this study, a total of 113 patients were ultimately included in the analysis. Variables such as age, preoperative Glasgow Coma Scale (GCS) scores, and hemorrhage locations were assessed.

Emergy-based evaluation of production efficiency and sustainability of diversified multi-cropping systems in the Yangtze River Basin.

Excessive agricultural investment brought about by increased multiple-cropping index may compromise environmental sustainability. There are few studies on the sustainability of diversified multi-cropping systems in the Yangtze River Basin (YRB). Therefore, this study selected five representative locations in the YRB.

Reconfigurable topological wave routing based on tunable valley kink states and valley-polarized chiral edge states.

Valley kink states and valley-polarized chiral edge states, whose topologically protected one-way propagation property provides a promising solution for manipulating light waves, have recently attracted considerable attention in topological photonics. However, it remains a great challenge to realize flexibly tunable dispersion for two different topological states and to develop a dynamically controllable topological photonic platform for switching topological wave routing. In this work, we propose a reconfigurable topological wave routing structure in the telecommunication frequency range, where phase-change material SbS cylinders with tunable refractive index are embedded into each topological channel to dynamically tune the dispersion of topological edge states.

Predictive value of systemic immune-inflammatory biomarkers for drug-induced liver injury in hepatitis B virus surface antigen positive tuberculosis patients: A retrospective observational study.

Drug-induced liver injury (DILI) is a major concern in tuberculosis (TB) treatment. For early detection of DILI, immune-inflammatory biomarkers are needed for better management. To explore the predictive effect of systemic immune-inflammation index (SII) combined with neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), eosinophil (EOS%), and CD4/CD8 on DILI occurrence in TB patients with HBsAg positive.

A Novel Unilateral Bi/Multi-Portal Endoscopic Transforaminal Interbody Fusion Utilizing Uniaxial Spinal Endoscope Instead of Arthroscope: Technical Note and Preliminary Clinical Results.

Background: Currently, traditional UBE surgery, which is based on arthroscope, has been increasingly employed for complex lumbar degenerative diseases. However, this approach is associated with complications such as intraoperative dural sac tears, nerve root injuries, and postoperative epidural hematomas. In response to these challenges, we propose a novel technique utilizing uniaxial spinal endoscope to replace arthroscope-Unilateral Bi/Multi-Portal Endoscopy (UME).

Navigating the immune landscape with plasma cells: A pan-cancer signature for precision immunotherapy.

Immunotherapy has revolutionized cancer treatment; however, predicting patient response remains a significant challenge. Our study identified a novel plasma cell signature, Plasma cell.Sig, through a pan-cancer single-cell RNA sequencing analysis, which predicts patient outcomes to immunotherapy with remarkable accuracy.

Effect of Upper Robot-Assisted Training on Upper Limb Motor, Daily Life Activities, and Muscular Tone in Patients With Stroke: A Systematic Review and Meta-Analysis.

Background: Upper limb rehabilitation robot is a relatively new technology, but its effectiveness remains debatable due to the inconsistent results of clinical trials. This article intends to assess how upper limb rehabilitation robots help the functional recovery of stroke patients.

Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched for eligible studies to explore the effect of upper limb rehabilitation robots on upper limb motor function, muscle tone, and daily living activities.

Topological traveling-wave radiation based on chiral edge states in photonic Chern insulators.

Topological chiral edge states in photonic Chern insulators, which exhibit the one-way propagation property with reflection-free behavior and excellent robustness against perturbations, have become an important frontier in topological photonics. Currently, there have been many studies on its robust propagation behavior, but few studies have focused on its radiation properties. In developing functional photonic devices (e.

Associations between amyloid-β load and cognition in cerebrovascular disease beyond cerebral amyloid angiopathy: a systematic review and meta-analysis of positron emission tomography studies.

Background: There is growing interest in the comorbidity of vascular and neurodegenerative pathologies in patients with cerebrovascular disease (CVD) beyond cerebral amyloid angiopathy (CAA). However, the relationship between amyloid-β and vascular cognitive impairment (VCI) remains debated.

Objective: To investigate the association between VCI and amyloid-β deposition in non-CAA CVD patients.

[Preparation of fluorescent carbon dots by flow-assisted melt polymerization for tetracycline detection in medical wastewater].

Tetracycline (TC) is one of the most important therapeutic drugs that is widely used in hospitals. However, its harmful effects on human health and various ecosystems cannot be ignored. Owing to its poor metabolic activity and low biodegradability, TC commonly discharges as the parent compound and accumulates readily in sludges and soils by precipitation from wastewater, which can induce the evolution of antibiotic-resistant bacteria; therefore, it has been listed as one of the new pollutants with potential ecotoxicological risk.

Exploring the link between dietary zinc intake and endometriosis risk: insights from a cross-sectional analysis of American women.

Background: Endometriosis is a complex disorder with genetic, immune, inflammatory, and multifactorial etiologies. Zinc, an essential trace element, plays a crucial role in various physiological processes. Dysregulation or deficiency of zinc can lead to aberrations in human physiology.

Association between dietary vitamin B6 intake and endometriosis risk: evidence from the national health and nutrition examination survey.

Background: Endometriosis is a multifaceted disorder with genetic, immune, inflammatory, and multifactorial origins. Vitamin B6 serves as a pivotal coenzyme in various metabolic pathways involving lipids, hemes, nucleic acids, proteins, and carbohydrates. Dysregulation or deficiency of vitamin B6 can perturb human physiology.