Publications by authors named "Feng K"

Cranial defect repair remains a significant challenge in neurosurgery, and designing material complexes that can support bone regeneration while minimizing complications such as infection and inflammation could help alleviate this clinical challenge. This study presents a photothermal hydrogel complex with a controlled rapid gelation process, PDA-G-A-H, which integrates photothermal polydopamine nanoparticles (PDA NPs) with gentamycin (G) and alendronate acid (A). Furthermore, the incorporation of the injectable hydrogel Pluronic F127 and collagen (H) made this composite hydrogel (PDA-G-A-H) suitable for the multifaceted needs of cranial defects.

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  • This study aimed to explore the link between glycemic control and lung health using data from 5,610 participants in the NHANES survey from 2007-2012, focusing on respiratory symptoms and lung function tests.
  • Results indicated that a 1% increase in blood glucose was negatively correlated with lung function, leading to reduced forced expiratory volume (FEV1) and forced vital capacity (FVC), along with a higher risk of breathing difficulties and mortality for those with restrictive lung disease.
  • Improved glycemic control was associated with early markers of lung damage, whereas poor control correlated with more severe lung dysfunction, emphasizing the importance of managing blood glucose levels for respiratory health.
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Background: Though widely used, resting heart rate (RHR), as measured by a wearable device, has not been previously evaluated in a large cohort against a variety of important baseline characteristics.

Objective: This study aimed to assess the validity of the RHR measured by a wearable device compared against the gold standard of ECG (electrocardiography), and assess the relationships between device-measured RHR and a broad range of clinical characteristics.

Methods: The Project Baseline Health Study (PHBS) captured detailed demographic, occupational, social, lifestyle, and clinical data to generate a deeply phenotyped cohort.

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SARS-CoV-2 has posed serious global health challenges not only because of the high degree of virus transmissibility but also due to its severe effects on the respiratory system, such as inducing changes in multiple organs through the ACE2 receptor. This virus makes changes to gene expression at the single-cell level and thus to cellular functions and immune responses in a variety of cell types. Previous studies have not been able to resolve these mechanisms fully, and so our study tries to bridge knowledge gaps about the cellular responses under conditions of infection.

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Lung adenocarcinoma, a subtype of lung cancer, is produced by uncontrolled proliferation of somatic cells affected by some tumorigenic factors. The origin of this disease can be attributed to the concept of "cancer driver," which links the occurrence of tumor with specific changes in some key genes. These key genes can be identified at various molecular levels.

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Background: This study aimed to summarize the pathogenic spectrum of infective endocarditis (IE) and analyze the risk factors for poor prognosis in surgical patients in a tertiary hospital in China.

Methods: We retrospectively included patients diagnosed with IE between January 2013 and January 2022. The pathogenic spectrum was summarized; the risk factors for early postoperative mortality and embolic events were analyzed using multivariate logistic regression.

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Background: Osteoarthritis (OA) is a prevalent degenerative joint condition, and emerging evidence suggests that dietary factors, such as coffee consumption, may influence its risk. However, the relationship between coffee consumption and the risk of developing OA remains ambiguous. This study aims to explore the association between coffee intake and OA complemented by Mendelian randomization (MR) to infer causality.

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Background: The increasing utilization of computed tomography (CT) scans has significantly elevated the detection rate of pulmonary nodules. Pulmonary segmentectomy has become the preferred surgical technique for peripheral non-small cell lung cancer (NSCLC) measuring 2 cm or smaller. Various methods for identifying the intersegmental planes (ISPs) are currently employed.

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Ulcerative colitis (UC) is a relapsing disease with an increasing morbidity and prevalence. Dietary polysaccharides have recently become a research hotspot because of their therapeutic effects and safety on UC. Our previous research elucidated that pectic polysaccharide from Phyllanthus emblica L.

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Infectious laryngotracheitis (ILT) is a highly contagious disease, usually controlled by vaccination with live attenuated vaccines. However, the latent infection and adverse reactions caused by the live attenuated vaccines against infectious laryngotracheitis virus (ILTV) have limited its use in poultry. Infectious bronchitis virus (IBV) is considered a potential vector for vaccine development, but the issue of poor stability in recombinant IBV expressing foreign genes has not yet been resolved.

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The ionome represents elemental composition in plant tissues and can be an indicator of nutrient status as well as overall plant performance. Thus, identifying genetic determinants governing elemental uptake and storage is an important goal for breeding and engineering biomass feedstocks with improved performance. In this study, we coupled high-throughput ionome characterization of leaf tissues with high-resolution genome-wide association studies (GWAS) to uncover genetic loci that modulate ionomic composition in leaves of poplar ().

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This work introduces a fluorometric/electrical dual-biosensing logic system based on a DNA reaction network (DRN). This system was used to spatiotemporally modulate the kinetic behavior of DNA nanostructures. The system, acting as a programmable and modulative central controller introduced to implement, enabled the monitoring of the target gliotoxin.

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Automatic single particle picking is a critical step in the data processing pipeline of cryo-electron microscopy structure reconstruction. In recent years, several deep learning-based algorithms have been developed, demonstrating their potential to solve this challenge. However, current methods highly depend on manually labeled training data, which is labor-intensive and prone to biases especially for high-noise and low-contrast micrographs, resulting in suboptimal precision and recall.

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Scar formation and chronic refractory wounds pose a significant threat to public health, with abnormal immune regulation as a key characteristic. However, topography, a crucial factor influencing immune responses, has not been adequately considered in the design of wound dressings. In this study, we constructed a hierarchical structure on silk fibroin (SF) films by combining soft lithography and femtosecond laser ablation, without altering the intrinsic properties of SF.

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Background: Polyethylene glycol loxenatide (PEG-Loxe) is applied in treating type 2 diabetes mellitus. Nevertheless, the effect and mechanism of PEG-Loxe on lipid metabolism disorder and insulin resistance in type 2 diabetes mellitus are not fully understood.

Methods: Type 2 diabetes mellitus rats developed by high-fat diet/streptozotocin injection were treated with PEG-Loxe (0.

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  • The study analyzed data from 1071 metastatic breast cancer patients to explore the characteristics and treatment impacts of those with HER2-low status, emphasizing the need for improved clinical guidance in this population.
  • Key mutations found in HER2-low patients include TP53, PIK3CA, and ESR1, which are linked to metabolic changes and could influence treatment responses.
  • Results indicate that while HER2-low and HER2-0 patients generally respond similarly to standard treatments, those with specific genetic mutations may benefit more from personalized approaches, supporting the development of tailored treatment strategies based on tumor characteristics.
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  • Infectious bursal disease (IBD), caused by IBDV, significantly threatens the poultry industry due to its ability to weaken the immune system and the rise of severe virus strains.
  • Traditional vaccines have shortcomings, prompting research into a new vaccine that uses a recombinant Newcastle disease virus (NDV) to express important IBDV proteins (VP2 and VP3) for better immune response.
  • The study found that the new rNDV-VP2-VP3 vaccine generated stronger antibody responses and offered better protection against IBDV compared to previous vaccine methods, suggesting it could effectively control IBD in poultry.
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Caffeic acid-3-O-methyltransferase (COMT) serves as the final pivotal enzyme in melatonin biosynthesis and plays a crucial role in governing the synthesis of melatonin in plants. This research used bioinformatics to analyze the phylogenetic relationships, gene structure, and promoter cis-acting elements of the upland cotton COMT gene family members, which it identified as the key gene GhCOMT33D to promote melatonin synthesis and responding to Cd stress. After silencing GhCOMT33D through virus-induced gene silencing (VIGS), cotton seedlings showed less resistance to Cd stress.

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  • Vein grafts are critical for treating coronary artery disease, but neointimal hyperplasia (NIH) poses a significant challenge to their long-term success, with current identification and intervention methods being insufficient.
  • Researchers conducted a study using rats to observe the NIH development process after vein grafting while examining gene expression and specific markers related to NIH through various analytical methods.
  • The results showed that repair cells from outside the graft contribute significantly to NIH, with the protein Fhl1 playing a protective role against inflammation and cell proliferation, offering potential targets for improved treatments.
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  • The tumor microenvironment significantly influences how cancer cells change their metabolism, and understanding these mechanisms could help in developing new treatments.
  • The study identified a circular RNA called circEPB41(2) that promotes lipid metabolism in liver cancer (HCC) and is induced by low glucose levels.
  • Targeting the interaction between circEPB41(2), the m6A demethylase FTO, and the histone deacetylase SIRT6 may offer a new approach to treat HCC, as high levels of circEPB41(2) correlate with poorer patient outcomes.
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Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria.

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All-solid-state lithium batteries (ASSLBs) with non-flammable solid-state electrolytes offer high energy density and enhanced safety. However, their energy densities are greatly limited by low-capacity and low-ionic-conductivity oxide cathode materials, typically relying on the intercalation-deintercalation mechanism with a catholyte content of 15-30 wt %. Here we introduce the LiFeX (X=Cl, Br) families as high-capacity and high-ionic-conductivity alternatives, operating via a 3 mol e transfer intercalation-conversion coupling reaction.

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Polybrominated biphenyl ethers (PBDEs) have been pervasively used as an additive flame retardant in various fields. The nature of environmental persistence, bioaccumulation, and potential toxicity attracted attention worldwide and became a threat to both the ecosystem and human health. Originally, PBDEs are produced in chemical factories.

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The current key issues in applying acoustofluidics in engineering lie in the inflexibility of manufacturing processes, particularly those involving modifications to piezoelectric materials and devices. This leads to inefficient prototyping and potentially high costs. To overcome these limitations, we proposed a technique that is capable of prototyping acoustofluidic devices in a straightforward manner.

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  • - The study examines various fertilizer combinations (from no fertilizer to different mixes of chemical and organic fertilizers) and their effects on cotton yield and soil quality over a 10-year period.
  • - Results indicated that the combination of 75% chemical and 25% organic fertilizer (M1) produced the highest cotton yield, while the 50% chemical and 50% organic fertilizer (M2) offered the best long-term sustainability in yield.
  • - Key soil health indicators, like organic matter and nitrogen levels, improved significantly under the M1 treatment, suggesting effective fertilization strategies are crucial for maintaining soil quality and crop productivity.
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