Engineering an enzyme-like catalytic sensor for on-site dual-mode evaluation of total antioxidant capacity.

A novel Fe-MoO nanozyme, engineered with enhanced peroxidase (POD)-like activity through strategic doping and the creation of oxygen vacancies, is introduced to catalyze the oxidation of TMB with high efficiency. Furthermore, Fe-MoO is responsive to single electron transfer (SET) and hydrogen atom transfer (HAT) mechanisms related to antioxidants and can serve as a desirable nanozyme for total antioxidant capacity (TAC) determination. The TAC colorimetric platform can reach a low LOD of 0.

Interaction of high seawater temperature and light intensity on photosynthetic electron transport of eelgrass (Zostera marina L.).

The interaction of widely recognized causes of eelgrass decline (high seawater temperature and limited light intensity) on photosynthetic electron transport was investigated via chlorophyll fluorescence technique. High seawater temperature combined light intensity significantly increasing the relative maximum electron transport rate (rETR); at critical temperature of 30 °C, the rETR increased with the enhancement of light intensity, indicating the elevation of overall photosynthetic performance. Based on the magnitude of effect size (η), light intensity was the predominant factor affecting the performance index (PI), indicating that photosystem II (PSII) was sensitive to light intensity.

In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy.

The aim of this study was to prepare, characterize novel types of pH-sensitive konjac gum-xanthan gum-glycerol-sodium alginate hydrogel (KGM-XG-GLY-SA hydrogel) allowing for the site-specific delivering of drugs to the colon and evaluate its colon-targeting characteristic. In this study, hydrophilic drug of hydrocortisone sodium succinate (HSS) was chosen as a model drug and successfully loaded in hydrogel without any organic solvent. In vitro investigations were carried out to evaluate its release process.

Application of traditional Chinese medicine preparation in targeting drug delivery system.

Targeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years.