Publications by authors named "Feng Hao"

This work examined the attachment of porcine rotavirus (PRV) and Tulane virus (TV), a surrogate for human norovirus, to fresh and artificial phylloplanes of Romaine lettuce and Carmel spinach. The effect of produce type, sanitizer, and ultrasound treatment on removal of PRV and TV from produce and artificial surfaces was also investigated. Sanitization was performed with two oxidant-based sanitizers (chlorine and peroxyacetic acid) and one surfactant-based sanitizer (0.

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Objectives: To explore the mechanism of moxibustion in improving synovitis inflammatory injury in rheumatoid arthritis (RA) model rats based on the ferroptosis-lipid metabolism pathway.

Methods: Forty-eight SD rats were randomly divided into normal, model, moxibustion and moxibustion + long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor groups, with 12 rats in each group. The RA model was replicated using environmental factors of wind, cold, and dampness combined with Freund's complete adjuvant injection.

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Background: Cerebral small vessel disease (CSVD) is a common disease in the elderly, and its pathogenesis is still being explored. Glymphatic clearance function can be evaluated by diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index. This study aims to investigate the changes in glymphatic clearance function in CSVD patients and its relationship with imaging markers and risk factors of CSVD.

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  • * A study involving 30 patients with lenvatinib-resistant HCC indicated that combining lenvatinib with the EGFR-TKI gefitinib resulted in some positive outcomes, with 30% of patients showing partial response and almost 47% stable disease.
  • * The combination therapy demonstrated a median progression-free survival of 4.4 months and an overall survival of 13.7 months, with a significantly higher objective response rate compared to existing second-line therapies, suggesting the need for further research.
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Background: The thrombocytopenia influences prognoses of critically ill patients. There are few studies exploring the prognostic value of thrombocytopenia among ICH patients. We perform this study to explore the correlation between thrombocytopenia at different timepoints of hospitalizations and mortality of ICH.

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Objective: This study aimed to investigate the proportion of neutrophils among leukocytes, in various tissues following intraperitoneal injection of and in mice.

Methods: Twelve specific-pathogen free (SPF) male mice, aged eight weeks, were segregated into three groups, each containing four mice. Two of these groups were subjected to intraperitoneal injections of and , both in high concentrations, to establish mouse models of inflammation.

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Human babesiosis, caused by several parasites and transmitted by tick bites and other blood-associated containments, has emerged as a major public health threat around the world. In the absence of readily discernible clinical manifestations, the diagnosis of human babesiosis has been contingent upon the identification of parasites through the utilization of detection arrays. Nevertheless, cases of persistent and relapsing babesiosis with low-grade parasitemia have been sporadically observed in patients with and without immunosuppression, prompting a challenge to the reliability of routine clinical laboratory tests and efficient anti-babesial therapy.

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  • The study aimed to identify factors contributing to abnormal liver function in patients undergoing laparoscopic esophageal hiatal hernia repair, analyzing data from 347 patients between January 2018 and November 2023.!
  • Among the patients, 68.6% displayed liver function abnormalities post-surgery, with notable differences found in type of hernia, hypotension, and operation time when comparing the abnormal liver function group to the normal function group.!
  • Logistic regression analysis indicated that prolonged surgical duration, larger hernia size, and specific clinical indicators were associated with a higher likelihood of liver function issues following the procedure.!
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Due to the development of next-generation sequencing technology and an increased appreciation of their role in modulating host immunity and their potential as therapeutic agents, the human microbiome has emerged as a key area of interest in various biological investigations of human health and disease. However, microbiome data present a number of statistical challenges not addressed by existing methods, such as the varying sequencing depth, the compositionality, and zero inflation. Solutions like scaling and transformation methods help to mitigate heterogeneity and release constraints, but often introduce biases and yield inconsistent results on the same data.

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Patients may rely on health insurance physician directories to determine who is in-network and inaccuracies in these directories may lead to delayed access to treatment, unexpected out-of-pocket costs, and increased barriers to care. This cross-sectional study quantifies the accuracy of state-specific Medicaid directories regarding board-certified pediatric dermatologists, and compares physicians listed accurately with those listed inaccurately by type of practice and region of practice. The accuracy of all state Medicaid physician directories was 84.

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  • * The study investigates a new drying method called variable frequency contact ultrasonic drying (CUD), which operates at specific frequencies and temperatures, and compares it to traditional methods like spray and hot air drying.
  • * Findings show CUD significantly improves the drying process by increasing moisture diffusivity, reducing drying time, and preserving protein quality, resulting in better foaming capacity, stability, and overall appearance of the albumen powder.
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Currently, the diagnosis of malocclusion is a highly demanding process involving complicated examinations of the dental occlusion, which increases the demand for innovative tools for occlusal data monitoring. Nevertheless, continuous wireless monitoring within the oral cavity is challenging due to limitations in sampling and device size. In this study, by embedding high-performance piezoelectric sensors into the occlusal surfaces using flexible printed circuits, a fully integrated, flexible, and self-contained transparent aligner is developed.

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  • * The study involved a 1:2 case-control approach, which discovered that 22.5% of the 80 exposed people had acute infections, notably higher than the 2.9% infection rate in unexposed individuals, with cucumber in sauce identified as a significant risk factor.
  • * Investigation also revealed poor kitchen hygiene practices, such as mixing utensils for raw and cooked foods, leading to cross-contamination from defrosted pork; overall findings highlight the need for better food hygiene education in rural areas
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Objective: To explore the mechanism for mesoporous silica nano-modified ginsenoside Rh2 promoting tumor immunosuppression in lung cancer through PD-1/PD-L1 pathway.

Methods: Firstly, G-Rh2-MSN were prepared and lung cancer A549 cells were cultured. The following groups were set up to analyze whether G-Rh2-MSN down-regulates PD-1/PD-L1 to promote tumor immunity, inhibit activities of lung cancer cells, and promote apoptosis: Model control group, G-Rh2 group, G-Rh2-MSN group, G-Rh2-MSN+PT001 group, G-Rh2-MSN+nivolumab group, G-Rh2-MSN+Durvalumab group, G-Rh2-MSN+atezolizumab group, and G-Rh2-MSN+nivolumab+Durvalumab group.

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This study evaluated the nutritional and functional qualities of the mushroom stem (MS) powder and its protein concentrates, which were extracted using alkaline and deep eutectic solvent (DES)-based methods. MS powder is rich in protein (23.02 %) and carbohydrates (63.

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Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent marker for discerning TICs in hepatocellular carcinoma (HCC), outperforming other commonly used TIC markers. CD49f-high TICs specifically recruit tumor-promoting neutrophils via the CXCL2-CXCR2 axis and create an immunosuppressive milieu in the tumor microenvironment (TME).

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  • Research involved various assays (like PCR and Western blot) to analyze the relationship between Lnc NEAT1, miR-152-3p, and CDK6, revealing that Lnc NEAT1 is positively linked to CDK6 and negatively linked to miR-152-3p.
  • The study concluded that Lnc NEAT1 promotes melanoma cell growth and migration by acting as a sponge for miR-152-3p, leading to increased CDK6 levels, highlighting its potential as a target for melanoma treatment.
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RNF135, also known as RIPLET, plays a crucial role in facilitating RIG-I signaling in mammals. However, the function and regulatory mechanism of RNF135 in teleosts remain much to be elucidated. In this study, RNF135 homolog of black carp (bcRNF135) has been cloned and identified.

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Objectives: To evaluate the immunogenicity and osteogenic ability of animal-derived bone graft material decellularized with supercritical carbon dioxide.

Methods: Porcine femurs were randomly divided into two groups after preliminary treatment, and decellularized with conventional method (conventional control group) or supercritical carbon dioxide (experimental group). Clearance rate of galactose-α-1, 3-galactose (α-Gal) and residual DNA of the two groups were analyzed to assess the immunogenicity of the xenogenic materials.

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